Anxiety control by astrocytes in the lateral habenula

Tan, Wanqin; Ikoma, Yoko; Takahashi, Yusuke; Konno, Ayumu; Hirai, Hirokazu; Hirase, Hajime; Matsui, Ko

doi:10.1016/j.neures.2024.01.006

Cited by 1 publication

(3 citation statements)

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“…Similar mechanisms may operate in normal physiological situations for the volume control of the general neuronal excitability, which may switch the mode of information processing, and for meta-plasticity control (Asano et al, 2023;Tan et al, 2024).…”

Section: Discussionmentioning

confidence: 95%

“…How to cite this article: Araki, S., Onishi, I., Ikoma, Y., & Matsui, K. (2024). Astrocyte switch to the hyperactive mode.…”

Section: Conflict Of Interest Statementmentioning

confidence: 99%

“…The fluctuation of this recording would not be influenced by cytosolic Ca 2+ changes and should represent background changes affected by fluctuations in factors such as BBV and pH. If we assume that BBV and pH fluctuation affect fYFP and dYFP equally, then the difference between fYFP and dYFP could also yield a Ca 2+ change readout(Asano et al, 2023;Tan et al, 2024). In our recordings, we focused on the onset time of Ca 2+ increase.…”

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confidence: 99%

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Astrocyte switch to the hyperactive mode

Araki,

Onishi,

Ikoma

et al. 2024

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Increasing pieces of evidence have suggested that astrocyte function has a strong influence on neuronal activity and plasticity, both in physiological and pathophysiological situations. In epilepsy, astrocytes have been shown to respond to epileptic neuronal seizures; however, whether they can act as a trigger for seizures has not been determined. Here, using the copper implantation method, spontaneous neuronal hyperactivity episodes were reliably induced during the week following implantation. With near 24‐h continuous recording for over 1 week of the local field potential with in vivo electrophysiology and astrocyte cytosolic Ca2+ with the fiber photometry method, spontaneous occurrences of seizure episodes were captured. Approximately 1 day after the implantation, isolated aberrant astrocyte Ca2+ events were often observed before they were accompanied by neuronal hyperactivity, suggesting the role of astrocytes in epileptogenesis. Within a single developed episode, astrocyte Ca2+ increase preceded the neuronal hyperactivity by ~20 s, suggesting that actions originating from astrocytes could be the trigger for the occurrence of epileptic seizures. Astrocyte‐specific stimulation by channelrhodopsin‐2 or deep‐brain direct current stimulation was capable of inducing neuronal hyperactivity. Injection of an astrocyte‐specific metabolic inhibitor, fluorocitrate, was able to significantly reduce the magnitude of spontaneously occurring neuronal hyperactivity. These results suggest that astrocytes have a role in triggering individual seizures and the reciprocal astrocyte‐neuron interactions likely amplify and exacerbate seizures. Therefore, future epilepsy treatment could be targeted at astrocytes to achieve epilepsy control.

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Section: Discussionmentioning

confidence: 95%

“…How to cite this article: Araki, S., Onishi, I., Ikoma, Y., & Matsui, K. (2024). Astrocyte switch to the hyperactive mode.…”

Section: Conflict Of Interest Statementmentioning

confidence: 99%

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confidence: 99%

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