Anxiety and self-perceived health status in Parkinson’s disease

Pontone, Gregory M.; Williams, James R.; Anderson, Karen E.; Chase, Gary A.; Goldstein, Susanne R.; Grill, Stephen; Hirsch, Elaina S.; Lehmann, Susan W.; Little, John T.; Margolis, Russell L.; Rabins, Peter V.; Weiss, Howard D.; Marsh, Laura

doi:10.1016/j.parkreldis.2011.01.005

Cited by 56 publications

(50 citation statements)

References 31 publications

(41 reference statements)

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“…Both motor symptoms and non‐motor symptoms might affect a patient's self‐perceived health status in PD . Although some studies on PD have hypothesized that anxiety and depression are associated with a lower perceived health status, only one study has shown that non‐motor symptoms have a negative impact on health‐related and perceived quality of life in PD. Here, we provide evidence showing that psychological features such as hopelessness and negative temperaments can contribute to higher perceived disability in PD.…”

Section: Discussionmentioning

confidence: 99%

Suicidal ideation, perceived disability, hopelessness and affective temperaments in patients affected by Parkinson's disease

et al. 2018

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Summary Background Previous studies investigating the risk of suicide in patients with Parkinson's disease (PD) have reported conflicting results. This study evaluated suicide risk in PD and investigated the relationship between suicide risk and perceived disability, hopelessness and affective temperaments in PD. Methods One‐hundred and twenty PD patients were consecutively enrolled. The diagnosis of PD was based on clinical criteria. All patients underwent a psychiatric evaluation that included the administration of the Columbia‐Suicide Severity Rating Scale, the Italian Perceived Disability Scale, the Beck Hopelessness Inventory and the TEMPS‐A questionnaire. The results were compared with those of a control group of 91 patients affected by another chronic disease, ie, open angle glaucoma. Results Parkinson's disease patients had higher suicidal ideation, higher perceived disability and lower hyperthymia than the control group. In PD, higher perceived disability was associated with higher current and lifetime suicidal ideation, lower hyperthymia, older age and higher scores on negative temperaments. Suicidal ideation, negative temperaments and hopelessness were risk factors for perceived disability, while hyperthymia was a protective factor for perceived disability. Discussion Patients with PD have an increased risk of suicidal ideation. Increased suicidal ideation in PD is associated with the increased perceived disability. A psychiatric assessment that includes the investigation of suicide risk and perceived disability is recommended in patients with PD.

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Section: Discussionmentioning

confidence: 99%

Suicidal ideation, perceived disability, hopelessness and affective temperaments in patients affected by Parkinson's disease

et al. 2018

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“…Not all studies reported each factor involved; one study addressed six factors out of seven [17] while another study addressed one out of seven factors [18]. Some studies have indicated that depression and anxiety disorders were associated with increased severity of the illness [21] and [12], younger PD onset age [21], [12], and [22] and longer disease duration [21] and [22], which support our analysis. Also, depression and anxiety disorders were found to be positively related to motor fluctuations and H/Y stage [6], [5], [23] and [24], which support the findings of our review.…”

Section: Discussionmentioning

confidence: 99%

Systematic review of factors associated with depression and anxiety disorders among older adults with Parkinson's disease

Sagna

Gallo

Pontone

2014

Parkinsonism & Related Disorders

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Depression and anxiety disorders have a substantial impact on the quality of life, the functioning and mortality of older adults with Parkinson’s disease (PD). The purpose of this systematic review was to examine the factors associated with the prevalence of depression and anxiety disorders among individuals with PD aged 60 years and older. Following a literature search in PubMed, PsycINFO, CINAHL, and EMBASE, 5 articles met the inclusion criteria (adults aged 60 years and older, individuals with PD, and with depression and anxiety disorders, and English-language peer reviewed articles) and were included in this review. These studies were conducted in the U.S (n=3), in Italy (n=1) and the U.K (n=1). Findings indicated that autonomic symptoms, motor fluctuations, severity and frequency of symptoms, staging of the disease, and PD onset and duration were associated with the prevalence of depression and anxiety disorders among older adults suffering from PD. Despite the limited number of studies included in the review, depression and anxiety disorders are often unrecognized and untreated and the comorbidity greatly exacerbates PD symptoms. The identification of factors associated with the development of depression and anxiety disorders could help in designing preventive interventions that would decrease the risk and burden of depression and anxiety disorders among older adults with PD.

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“…Many of these features are consistent with a PD subgroup experiencing atypical anxiety specifically associated with motor fluctuations (n=21) identified in an earlier study from this sample. (6) This subgroup with motor fluctuations may need optimization of dopaminergic drugs for the motor symptoms of PD in place of or in addition to standard anxiety treatments.…”

Section: Discussionmentioning

confidence: 99%

“…(3,6) Patients with idiopathic PD at each practice were mailed letters inviting their participation in the research study. Individuals were excluded if Mini-Mental State Exam (MMSE)(18) score was < 24.…”

Section: Methodsmentioning

confidence: 99%

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Pharmacologic Treatment of Anxiety Disorders in Parkinson Disease

Pontone

Williams

Anderson

et al. 2013

The American Journal of Geriatric Psychiatry

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Objective Neither best practices nor an evidence-base for the pharmacologic treatment of anxiety in Parkinson's disease has been established. This study investigated pharmacologic treatment of anxiety disorders in idiopathic Parkinson's disease and the associated clinical features. Design Cross-sectional. Setting Three community-based movement disorder neurology practices Participants 250 subjects with Parkinson's disease. Measurements Anxiety disorder diagnoses were established by consensus using a panel of six psychiatrists with expertise in geriatric psychiatry and movement disorders. Current medications were provided by the treating neurologists at the time of interview. Results Amongst subjects with anxiety disorders only, 53% were untreated with medications. However, when anxious subjects with comorbid depressive disorders were included, 70.8% were on medications effective for treatment of anxiety. Subjects with anxiety and comorbid depressive disorders were more likely to be treated for their psychiatric disturbances than subjects with anxiety disorders alone (Odds Ratio 8.33) as were subjects with comorbid motor fluctuations (Odds Ratio, 3.65). There were no differences in the types of anti-anxiety medications used in regard to the presence of depression or motor fluctuations. Conclusions These findings suggest that over half of non-depressed Parkinson's disease patients with clinically significant anxiety are untreated with medication. A better understanding of the role of clinical features associated with anxiety in PD, such as depression and motor fluctuations, may improve the recognition and treatment of anxiety disorders in this population.

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Anxiety and self-perceived health status in Parkinson’s disease

Cited by 56 publications

References 31 publications

Suicidal ideation, perceived disability, hopelessness and affective temperaments in patients affected by Parkinson's disease

Suicidal ideation, perceived disability, hopelessness and affective temperaments in patients affected by Parkinson's disease

Systematic review of factors associated with depression and anxiety disorders among older adults with Parkinson's disease

Pharmacologic Treatment of Anxiety Disorders in Parkinson Disease

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