Anxiety and dyslipidemia among primary health care professionals: A Cross-sectional study

Barbosa, Caroline da Silva; Mercês, Magno Conceição das; Santana, Amália Ivine Costa; Silva, Douglas de Souza e; Pimentel, Rodrigo Fernandes Weyll; Coelho, Julita Maria Freitas; Almeida, Alex Almeida e; Damasceno, Kairo Silvestre Meneses; Rossi, Thaís Régis Aranha; Júnior, Argemiro D’Oliveira

doi:10.3233/wor-205095

Cited by 6 publications

(5 citation statements)

References 31 publications

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“…2). The study found a correlation between anxiety symptoms and dyslipidemia in MDD patients, consistent with previous research (19)(20)(21)(22)30). In contrast to previous ndings, there was no notable difference in anxiety symptom rates between the EAO and MAO groups.…”

Section: Clinical Correlates Of Anxiety Symptoms In Eao and Mao Groupssupporting

confidence: 91%

“…On the other side, comorbid anxiety in MDD patients are associated with many metabolic disorders(e.g.dyslipidemia, impaired glucose and hypothyroidism). Previous studies have revealed that anxiety is correlated to serum lipid abnormalities in MDD patients (19,20). A systematic review showed that patients with heterozygous familial hypercholesterolemia exhibited differences in anxiety symptoms and mental health compared with the general population (21).…”

Section: Introductionmentioning

confidence: 99%

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Prevalence and clinical correlates of anxiety symptoms in first-episode and drug-naïve major depressive disorder patients with dyslipidemia at different ages of onset: a large cross-sectional study

Wang,

Liu,

et al. 2024

Preprint

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Background Major depressive disorder (MDD) patients often have different clinical manifestations at different age of onset. Anxiety symptoms are frequently seen in patients with MDD, and dyslipidemia is also prevalent in these populations. There is limited reporting on the frequency of anxiety symptoms and their associations with clinical factors in patients with abnormal lipid metabolism who have MDD. Methods Our study included 1718 first-episode untreated MDD outpatients aged 18–60 years, 1408 of whom had dyslipidemia. We collected basic information, clinically relevant data, and biochemical indicators from these patients. Anxiety, depression and psychiatric symptoms were evaluated by Hamilton Anxiety Scale (HAMA), Hamilton Depression Scale (HAMD) and Positive and Negative Syndrome Scale (PANSS) positive subscale, respectively. Results Anxiety symptoms were found in 57.8% of depressed outpatients with dyslipidemia, a rate significantly higher than in MDD patients with normal lipid levels. No statistical difference was observed in the prevalence of anxiety symptoms between the early adulthood onset (EAO) group and mid-adulthood onset (MAO) group. Anxiety symptoms were significantly correlated with both HAMD and PANSS scores, regardless of the age of onset. Thyroid-stimulating hormone (TSH), total cholesterol (TC) levels and suicide attempts were independently associated with anxiety symptoms in the EAO group, whereas fasting blood glucose (FBG) was independently related to anxiety symptoms in the MAO group. Conclusions Our research findings indicated that the age of MDD onset in patients with dyslipidemia did not impact the presence of anxiety symptom. The clinical factors linked to anxiety symptoms varied between the EAO and MAO groups, potentially aiding in the prediction of anxiety symptoms in the specific population.

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Section: Clinical Correlates Of Anxiety Symptoms In Eao and Mao Groupssupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Prevalence and clinical correlates of anxiety symptoms in first-episode and drug-naïve major depressive disorder patients with dyslipidemia at different ages of onset: a large cross-sectional study

Wang,

Liu,

et al. 2024

Preprint

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“…A study showed an increased risk of dyslipidemia in patients with anxiety disorders [15] . A Brazilian study found a positive association between anxiety and dyslipidemia [16] . However, the findings are not consistent.…”

Section: Introductionmentioning

confidence: 99%

Prevalence of dyslipidemia and its correlates in first-episode drug-naive major depressive disorder patients with comorbid anxiety symptoms: a large-scale cross-sectional study

Zhou,

Yuan

et al. 2023

Preprint

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BACKGROUND: Studies before this have found that individuals diagnosed with major depressive disorder (MDD) often experience issues with dyslipidemia. Also, people with MDD suffer from anxiety symptoms. However, few studies have looked into what factors contribute to dyslipidemia in individuals with both MDD and anxiety symptoms. Therefore, our study aimed to understand how common dyslipidemia is and what factors might be connected to it in individuals experiencing their first-episode drug-naive (FEDN) MDD with anxiety symptoms (MDDA). METHODS: A cumulative sample size of 1718 FEDN MDD patients was recruited. The Hamilton Depression Scale (HAMD), Hamilton Anxiety Scale (HAMA), and Positive and Negative Syndrome Scale (PANSS) positive subscale were the measures for the assessment of patients' mental states. Several metabolic panels were collected, including total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C) and thyroid hormone levels. RESULTS: The reported incidence of dyslipidemia in MDDA patients was 91.67%, which was significantly above that of MDD patients who did not suffer from anxiety symptoms (85.47%). In comparison with MDDA patients without dyslipidemia, those patients with dyslipidemia had higher body mass index (BMI), systolic blood pressure (SBP) and diastolic blood pressure (DBP), they also had increased levels on the HAMD, HAMA, and PANSS positive subscale. Additionally, greater levels of TC, HDL-C, TG, LDL-C, thyroid stimulating hormone (TSH), and fasting blood glucose (FBG) were found. Furthermore, the combination of HAMD, TSH, SBP and DBP distinguished MDDA patients with dyslipidemia from those without dyslipidemia. CONCLUSION: Our results suggested an increased incidence of dyslipidemia among MDDA patients. Various blood indicators and hormone levels were independently associated with dyslipidemia in MDDA patients. Furthermore, the combination of these factors may differentiate between MDDA patients with and without dyslipidemia.

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“…Several studies have reported an association between abnormal blood lipid levels and anxiety ( 16 , 17 ). Although some studies have highlighted a possible association between dyslipidemia and anxiety, few studies have investigated the relationship between dyslipidemia and anxiety symptoms in patients with MDD.…”

Section: Introductionmentioning

confidence: 99%

Prevalence and correlates of severe anxiety in patients with first hospitalization for major depressive disorder combined with dyslipidemia: a large sample cross-sectional study

Yin,

Zhang,

et al. 2024

Front. Psychiatry

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BackgroundAnxiety symptoms and dyslipidemia are common co-morbidities in patients with major depressive disorder (MDD), and there are complex pathophysiologic as well as clinical mechanisms underlying the association between the three. In this study, we investigated the prevalence and associated factors of severe anxiety in first-time hospitalized patients with MDD with dyslipidemia.MethodsWe included 708 patients with major depressive disorder with comorbid dyslipidemia and collected their sociodemographic and general clinical data as well as biochemical parameters such as lipids, thyroid function, and blood glucose. We also completed the Hamilton Anxiety Scale (HAMA), Hamilton Depression Scale (HAMD), Positive Symptom Scale (PSS), and Clinical General Impression Scale (CGI) to assess their clinical symptoms.ResultsThe prevalence of severe anxiety disorder was 11.02% in patients with MDD with comorbid dyslipidemia. Suicidal history, female gender, body mass index (BMI), HAMD score, PSS score, and FT4 level were risk factors for the development of severe anxiety symptoms. Higher HAMD scores, higher PSS scores, and suicidal history were influential factors in exacerbating severe anxiety symptoms.ConclusionThis study reports and identifies the prevalence of severe anxiety symptoms in first-time hospitalized MDD patients with dyslipidemia, as well as risk factors for anxiety symptoms and factors influencing their severity, and these identified factors may be potentially helpful and informative in preventing and intervening in severe anxiety disorders in this target population.

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Anxiety and dyslipidemia among primary health care professionals: A Cross-sectional study

Cited by 6 publications

References 31 publications

Prevalence and clinical correlates of anxiety symptoms in first-episode and drug-naïve major depressive disorder patients with dyslipidemia at different ages of onset: a large cross-sectional study

Prevalence and clinical correlates of anxiety symptoms in first-episode and drug-naïve major depressive disorder patients with dyslipidemia at different ages of onset: a large cross-sectional study

Prevalence of dyslipidemia and its correlates in first-episode drug-naive major depressive disorder patients with comorbid anxiety symptoms: a large-scale cross-sectional study

Prevalence and correlates of severe anxiety in patients with first hospitalization for major depressive disorder combined with dyslipidemia: a large sample cross-sectional study

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