Anxiety and depressive symptoms are related to core symptoms, general health outcome, and medical comorbidities in eating disorders

Martín, Josune; Aróstegui, Inmaculada; Loroño, Ane; Padierna, Ángel; Najera-Zuloaga, Josu; Quintana, José M.

doi:10.1002/erv.2677

Cited by 36 publications

(30 citation statements)

References 47 publications

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“…We can hypothesize that high segregation plays a protective role in AN, since it probably allows a more efficient cognitive processing, but we can also speculate that a lower integration may predispose to higher anxiety symptoms in the disorder. This finding supports the importance of therapeutically addressing anxiety symptoms when they occur in comorbidity with AN (Lloyd et al, 2019; Martín et al, 2019).…”

Section: Discussionsupporting

confidence: 78%

Functional Connectivity Patterns and the Role of 5-HTTLPR Polymorphism on Network Architecture in Female Patients With Anorexia Nervosa

et al. 2019

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IntroductionRecent neuroimaging studies suggest that anorexia nervosa (AN) symptoms emerge from failures in the relationships between spatially distributed networks that support different cognitive, emotional, and somatosensory functions. The 5-HTTLPR genotype has been shown to modulate all these abilities in AN, as well as the connectivity patterns between brain regions that support their functioning. This study aims at exploring the presence of any difference in functional connectome properties between AN patients and healthy controls (HC) by means of graph theory tools. The effect of 5-HTTLPR genotype on regional and global network characteristics in AN and HC was also explored.MethodsA sample of 74 subjects (38 HC, 36 AN) underwent a resting state functional magnetic resonance imaging and was genotyped for 5-HTTLPR polymorphism. Comparisons of network properties were made between the AN and HC groups and, within each group, between 5-HTTLPR carriers of low-functioning alleles and carriers of the long–long genotype.ResultsPatients with AN displayed lower network clustering than HC (p = 0.04 at Mann–Whitney U test). Based on both degree and betweenness, a different distribution of network hubs emerged in the two groups. In particular, the anterior part of the anterior cingulate cortex was a hub only in the patient group. A correlation emerged between differences in brain volumes between patients and HC and differences in degree values of basal ganglia, nodes in the insula, and those in the parietal cortex. Carriers of the short allele of the 5-HTTLPR polymorphism were characterized by lower small-world properties (p = 0.027) and modularity (p = 0.031) in the patient group, and a trend toward higher modularity (p = 0.033) and small-world values (p = 0.123) in the HC group.DiscussionPatients with AN showed differences in hubs distribution, providing evidence of the presence of a different functional architectural backbone in this group. Since some correlation emerged between different degree values of nodes and differences in volumes, further longitudinal studies are warranted to better understand the role of malnutrition on brain network architecture. The opposite effects of 5-HTTLPR polymorphism on global network characteristics in the two groups suggest an interaction of the short allele and malnutrition in modulating brain network properties.

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Section: Discussionsupporting

confidence: 78%

Functional Connectivity Patterns and the Role of 5-HTTLPR Polymorphism on Network Architecture in Female Patients With Anorexia Nervosa

et al. 2019

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“…Regarding the psychological features, depression and anxiety scores were significantly higher in the long-term group. A cross-sectional study revealed that depression and anxiety were related to eating disorder symptoms and anxiety was related to older age [40]. Thus, older age might have been a factor related to high anxiety in the current study.…”

Section: Discussionmentioning

confidence: 69%

Physical and psychological aspects of anorexia nervosa based on duration of illness: a cross-sectional study

Takakura

Aso

Toda

et al. 2019

BioPsychoSocial Med

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BackgroundWe evaluated physical and psychological features of patients with anorexia nervosa (AN) who differed by duration of illness.MethodsData were obtained from 204 female patients with AN, divided into two groups based on illness duration: short-term illness duration (less than 5 years; n = 118); and long-term duration (5 years or more; n = 86). Physical parameters were measured using blood serum testing and psychological aspects were assessed using various instruments.ResultsA significantly higher proportion of restricting type AN was observed in the short-term group while the proportion of binge eating/purging type AN was higher in the long-term group. There was no difference in body mass index (BMI) between the groups. Serum total protein, albumin, potassium, chloride, and calcium in the long-term group were significantly lower than in the short-term group. Overall scores on the Eating Disorder Inventory as well as most of the subscales, except maturity fears, were higher in the long-term group than in the short-term group. The care subscale of the Parental Bonding Instrument (PBI) was lower in the long-term group than in the short-term group, while the overprotection subscale of the PBI was higher in the long-term group than in the short-term group. Results of a multiple regression analysis indicated that the overprotection subscale of the PBI was the only significant predictor of duration of illness.ConclusionsDuration of illness may be associated with physical and psychological features of AN; thus, adapting therapeutic approaches to illness duration might be necessary.

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“…Similarly to autism, eating disorders are frequently found to be comorbid with anxiety (Bulik et al 1997 ; Griffiths et al 2019 ; Hudson et al 2007 ; Martín et al 2019 ) and depressive disorders (Griffiths et al 2019 ; Hudson et al 2007 ; Martín et al 2019 ). Anorexia nervosa (AN) and bulimia nervosa (BN), but not binge-eating disorder (BED), also exhibit marked sex/gender differences in their prevalence.…”

Section: Introductionmentioning

confidence: 99%

The Association Between Autistic Traits and Disordered Eating is Moderated by Sex/Gender and Independent of Anxiety and Depression

Barnett

Edwards

Harper

et al. 2020

J Autism Dev Disord

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Previous studies have reported positive correlations between autistic traits and disordered eating, though it is unclear whether the association is moderated by sex/gender or whether it is independent of anxiety or depression. We present the findings of an online survey of 691 participants who completed the Autism Spectrum Quotient (AQ), Hospital Anxiety and Depression Scale (HADS), and Eating Attitudes Test-26 (EAT-26). Following a pre-registered analysis plan, we observed positive correlations between AQ and EAT-26 in males and females, with the association being significantly stronger in females. AQ also remained a significant predictor of EAT-26 when anxiety and depression were controlled for statistically. These findings may be relevant when considering therapeutic interventions in disordered eating populations that exhibit autistic traits.

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Anxiety and depressive symptoms are related to core symptoms, general health outcome, and medical comorbidities in eating disorders

Cited by 36 publications

References 47 publications

Functional Connectivity Patterns and the Role of 5-HTTLPR Polymorphism on Network Architecture in Female Patients With Anorexia Nervosa

Functional Connectivity Patterns and the Role of 5-HTTLPR Polymorphism on Network Architecture in Female Patients With Anorexia Nervosa

Physical and psychological aspects of anorexia nervosa based on duration of illness: a cross-sectional study

The Association Between Autistic Traits and Disordered Eating is Moderated by Sex/Gender and Independent of Anxiety and Depression

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