Anxiety and depressive disorders in offspring at high risk for anxiety: A meta-analysis

Micco, Jamie A.; Henin, Aude; Mick, Eric; Kim, Susie; Hopkins, Courtney A.; Biederman, Joseph; Hirshfeld‐Becker, Dina R.

doi:10.1016/j.janxdis.2009.07.021

Cited by 135 publications

(109 citation statements)

References 37 publications

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“…As noted earlier, family and twin studies have shown cross-disorder familial risk and high degrees of genetic correlation among the anxiety disorders, supporting the hypothesis that liability to these disorders involves a general anxiety diathesis (Hettema et al, 2005;Loken et al, 2014;Smoller et al, 2008a;Tambs et al, 2009b). In addition, offspring of parents with anxiety have a nearly three-fold increased odds of having depressive disorders compared with non-psychiatric control offspring (Micco et al, 2009). Conversely, first-degree relatives of individuals with MDD are at increased risk of BPD, ADHD, and anxiety disorders (Faraone and Biederman, 1997;Smoller, 2013;Smoller and Finn, 2003).…”

Section: Cross-phenotype Genetics Of Stress-related Disorderssupporting

confidence: 63%

The Genetics of Stress-Related Disorders: PTSD, Depression, and Anxiety Disorders

Smoller

2015

Neuropsychopharmacol

361

243

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Research into the causes of psychopathology has largely focused on two broad etiologic factors: genetic vulnerability and environmental stressors. An important role for familial/heritable factors in the etiology of a broad range of psychiatric disorders was established well before the modern era of genomic research. This review focuses on the genetic basis of three disorder categories-posttraumatic stress disorder (PTSD), major depressive disorder (MDD), and the anxiety disorders-for which environmental stressors and stress responses are understood to be central to pathogenesis. Each of these disorders aggregates in families and is moderately heritable. More recently, molecular genetic approaches, including genome-wide studies of genetic variation, have been applied to identify specific risk variants. In this review, I summarize evidence for genetic contributions to PTSD, MDD, and the anxiety disorders including genetic epidemiology, the role of common genetic variation, the role of rare and structural variation, and the role of gene-environment interaction. Available data suggest that stress-related disorders are highly complex and polygenic and, despite substantial progress in other areas of psychiatric genetics, few risk loci have been identified for these disorders. Progress in this area will likely require analysis of much larger sample sizes than have been reported to date. The phenotypic complexity and genetic overlap among these disorders present further challenges. The review concludes with a discussion of prospects for clinical translation of genetic findings and future directions for research.

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Section: Cross-phenotype Genetics Of Stress-related Disorderssupporting

confidence: 63%

The Genetics of Stress-Related Disorders: PTSD, Depression, and Anxiety Disorders

Smoller

2015

Neuropsychopharmacol

361

243

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“…However, at 3 year follow-up, this finding could not be replicated (Cobham, Dadds, Spence, & McDermott, 2010). More studies have linked current parental anxiety and depressive symptoms to higher levels of anxiety in offspring (Micco et al, 2009;Murray et al, 2009;Pilowsky et al, 2006). Furthermore, treatment outcome studies provide evidence that the presence of parental anxiety and depressive symptomatology is likely to be a barrier to child treatment outcome.…”

Section: Parental Temperament and Childhood Anxietymentioning

confidence: 97%

Temperament and parenting predicting anxiety change in cognitive behavioral therapy: The role of mothers, fathers, and children

Festen

Hartman

Hogendoorn

et al. 2013

Journal of Anxiety Disorders

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Take-down policy If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim. t r a c tObjective: A considerable amount of children with anxiety disorders do not benefit sufficiently from cognitive behavioral treatment. The present study examines the predictive role of child temperament, parent temperament and parenting style in the context of treatment outcome. Method: Participants were 145 children and adolescents (ages 8-18) with DSM-IV-TR anxiety disorders who received a 12-session CBT program and were assessed at pretreatment, posttreatment and three months follow-up. Multiple-regression analyses were used to evaluate the following pretreatment and posttreatment variables as potential predictors of treatment response at follow-up: baseline level of anxiety symptoms, child reported maternal and paternal rearing style (emotional warmth, rejection, and overprotection), parent reported child temperament traits (negative affect, effortful control, and extraversion), and mothers' and fathers' self-report temperament traits. Results: More maternal negative affect and less emotional warmth as perceived by the child before treatment were related to less favorable treatment outcome (accounting for 29% of the variance in anxiety at follow-up). Furthermore, maternal negative affect and children's extraversion measured after treatment also predicted anxiety at follow-up (together accounting for 19% of the variance). Paternal temperament and parenting style were unrelated to treatment outcome, as were children's pretreatment temperament traits. Conclusion:The results suggest that tailoring intervention to include strategies to reduce maternal negative affect and promote an emotional warm rearing style may improve treatment outcome.

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“…Cognitive vulnerability is suggested to interact with familial risk (e.g., negative and aversive family or peer experiences, insecure attachment with caregivers; Affrunti & WoodruffBorden, 2015; review by Waite, Whittington & Creswell, 2014), and exposure to specific threat experiences and challenging life events (e.g., Muris & Merkelbach, 2001;Oar, Farrell, & Ollendick, 2015;Rachman, 1998;Rapee, 2001). For example, while children inherit genes that increase vulnerability for anxiety (Hancock, Mitrou, Shipley, Lawrence & Zubrick, 2013;Micco et al, 2009), they are also more likely to experience an anxiogenic parenting style that can include parent over-control, parent modeling of anxiety and distress, and the sharing of negative information and avoidance of feared objects or events (Eley, 2015;review by Creswell Murray, Stacey & Cooper, 2011).…”

mentioning

confidence: 99%

Introduction to the Special Issue: Understanding the Role of Attentional Control in the Development of Anxiety in Childhood, Adolescence and across the Lifespan

Hadwin

Visu‐Petra

Muris³

et al. 2016

Journal of Experimental Psychopathology

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Anxiety is characterised by a distinctive emotional, cognitive and behavioural symptomatology. The central emotional symptoms are fear and apprehension, often evoked by the occurrence or anticipation of specific types of situations; the primary cognitive symptoms are negative thoughts and worries concerning the uncertainties and potential threats associated with such situations; and the main behavioural symptom is avoidance or attempted avoidance of these situations (Grills, Seligman & Ollendick, 2014). People differ in terms of the degree to which they are inclined to experience anxiety, which reflects a temperamental dimension known as trait anxiety. Trait anxiety is defined as a general and stable predisposition to experience worries and concerns across different contexts, and its presence increases current and transient feelings of state anxiety in the context of or expectation of threat (Gidron, 2013). Higher levels of trait anxiety are associated with intolerance of uncertainty, which reflects a preference for certainty and increased engagement in behaviours linked to the management and avoidance of situations that are unpredictable or ambiguous (Birrell, Meares, Wilkinson & Freeston, 2011; Chen & Lovibond, 2016). Individual differences in the disposition to experience anxiety are evident from early childhood, when elevated anxiety vulnerability typically manifests as behavioural inhibition (BI). Children with high levels of BI display negative reactions to novelty, heightened sensitivity to stimulus variations and withdrawal from social situations, which can result in peer rejection and reduced assertiveness (Fox & Pine, 2012). Early manifestations of heightened dispositional anxiety predict an increased tendency to experience problematic levels of anxiety in adolescence (Fox, Henderson, Marshall, Nichols & Ghera, 2005). In addition, longitudinal evidence supports multifactorial models in which anxious rearing and parental trait anxiety play a major role in the development

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Anxiety and depressive disorders in offspring at high risk for anxiety: A meta-analysis

Cited by 135 publications

References 37 publications

The Genetics of Stress-Related Disorders: PTSD, Depression, and Anxiety Disorders

The Genetics of Stress-Related Disorders: PTSD, Depression, and Anxiety Disorders

Temperament and parenting predicting anxiety change in cognitive behavioral therapy: The role of mothers, fathers, and children

Introduction to the Special Issue: Understanding the Role of Attentional Control in the Development of Anxiety in Childhood, Adolescence and across the Lifespan

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