Anxiety and depression symptoms and migraine: a symptom-based approach research

Peres, Mário Fernando Prieto; Mercante, Juliane Prieto Peres; Tobo, Patrícia Renovato; Kamei, Helder; Bigal, Marcelo E.

doi:10.1186/s10194-017-0742-1

Cited by 163 publications

(126 citation statements)

References 36 publications

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“…Higher plasma IL-12p70 (proinflammatory) concentrations were strongly negatively correlated with IL-10 (a Th2 cytokine) concentrations, in line with the well-known mutual negative regulation by these cytokines [25]. IL-12p70 was positively associated with both anxiety symptoms and migraine diagnosis, indicating a potential role for this cytokine in the overlap between migraine and anxiety disorders [14-16]. …”

Section: Introductionmentioning

confidence: 57%

“…These animal data, together with our previous clinical findings linking IL-12p70 with migraine and anxiety [24], underscore a potential role for this cytokine in mediating the overlap between migraine and anxiety disorders [14-16]. …”

Section: Discussionmentioning

confidence: 96%

“…Migraine is a common neurologic disorder and a leading cause of disability in the world, especially among young and middle-aged women [12, 13]. Besides headache, migraine disability is considerably increased by psychiatric symptoms/comorbidities, especially anxiety disorders [14-16]. Both during attacks or on headache-free days, migraine patients exhibit aberrant cytokine production, suggesting that immune dysregulation contributes to the pathogenesis of the disease [17-23].…”

Section: Introductionmentioning

confidence: 99%

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Exercise-Induced Change in Plasma IL-12p70 Is Linked to Migraine Prevention and Anxiolytic Effects in Treatment-Naïve Women: A Randomized Controlled Trial

Oliveira

Bachi²,

Ribeiro

et al. 2017

Neuroimmunomodulation

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Objective: To conduct a randomized controlled trial to evaluate the effect of a 12-week aerobic exercise program for migraine prevention, plasma cytokines concentrations (TNF-α, interleukin [IL]-1β, IL-6, IL-8, IL-10, and IL-12p70), and anxiety in women with migraine. Methods: Women with episodic migraine (ICHD-II), aged between 20 and 50 years, who had never taken any prophylactic medication, and were physically inactive in the past 12 months were recruited from the university’s hospital and a tertiary headache clinic between March 2012 and March 2015. Migraine attacks were recorded in headache diaries, cytokines were quantified by flow cytometry, and anxiety was assessed by the 7-item General Anxiety Disorder (GAD-7) scale. Blood sampling and psychometric interviews were undertaken on headache-free days. Results: Twenty participants ([mean ± SD] age 33.8 ± 10.5; BMI 26 ± 5.2) were randomly assigned and received intervention (“trained”: n = 10) or entered on a waitlist (“inactive”: n = 10). There were no differences between groups regarding patients’ characteristics and baseline data. Days with migraine (p = 0.001), IL-12p70 levels (p = 0.036), and GAD-7 score (p = 0.034) were significantly reduced in the trained group after the intervention period, but there were no significant changes in these variables in the inactive group. There was no change in the levels of the other cytokines in either group. There were positive correlations between a reduction in IL-12p70 level and a reduction in the number of days with migraine (R² = 0.19, p = 0.045), and GAD-7 score (R² = 0.53, p < 0.001). Conclusion: The clinical and psychological therapeutic effects of aerobic exercise in treatment-naïve women with migraine may involve the downregulation of IL-12p70.

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Section: Introductionmentioning

confidence: 57%

Section: Discussionmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

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Exercise-Induced Change in Plasma IL-12p70 Is Linked to Migraine Prevention and Anxiolytic Effects in Treatment-Naïve Women: A Randomized Controlled Trial

Oliveira

Bachi²,

Ribeiro

et al. 2017

Neuroimmunomodulation

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“…Jaradat et al have described that there was a significantly positive relationship between harsh work stress and tension-type headaches among nurses in both genders [28]. Not only tension-type headaches but also migraines are related to depression and anxiety [29] [30]. There also have a report that drug induced headaches are affiliated with anxiety [30].…”

Section: Discussionmentioning

confidence: 95%

Unhealthy Mental States Are Positively Associated with Subjective Pain or Fatigue in Specific Body Sites among High School Teachers in Japan

Murakami¹,

Tsumura²,

Sato³

et al. 2017

Health

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Unhealthy mental states have become common among teachers recently. Subjective physical symptoms are more likely to appear more readily than mental symptoms. In this study, we revealed that the relationship between mental states and subjective physical fatigue or pain in seven body sites among 2449 teachers. The 12-item General Health Questionnaire (GHQ-12) was used to assess mental state. We defined a score of 4 points and over in the GHQ-12 score as unhealthy mental state. We also asked about the presence of subjective physical fatigue or pain in each seven body sites in the past one year. In the results, 30.3% unhealthy mental states were found in females and 22.9% in males. Most of subjective physical fatigue or pains were detected in neck and shoulder, eyes, head and low back. Using multivariate logistic regression, higher scores in the GHQ-12 were positively associated with presence of subjective fatigue or pain in head and eyes in both genders, in lower extremities among females, and in back, upper extremities among males. Our results suggest that physical symptoms in specific body sites with gender differences may be useful in the early identification of unhealthy mental states among teachers. We should have efforts to pay attention to mental states among high school teachers if their symptoms do not get better after taking physical care.

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“…Migraine is a chronic neurological disease characterized by episodic attacks comprising head pain with a host of prodromal/accompanying symptoms, and constitutes a leading cause of disability worldwide . Migraine is associated with several psychophysiological factors, personality traits, and is comorbid with many psychiatric disorders, indicating that this disease affects behavioral and neurophysiological functioning. In this regard, several constructs have been applied to determine specific psychological characteristics of individuals with migraine, and their implications in terms of management and treatment approaches …”

Section: Introductionmentioning

confidence: 99%

Optimism, Pessimism, and Migraine: A Cross‐Sectional, Population‐Based Study

et al. 2019

Self Cite

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Background.-Optimism and pessimism are related to several mental health and brain disorders, are significant predictors of physical and psychological health outcomes, and implicated as psychosocial determinants of the pain experience. Despite this promising evidence, limited information is available on optimism and pessimism in headache disorders.Objective.-To evaluate the influence of optimism and pessimism in meeting criteria for migraine and related disability in a population-based sample.Methods.-This is an observational, cross-sectional study. The sample population was selected through a stratified, multistage area probability sample of households, as used by the last Brazilian Census. A validated questionnaire eliciting data on demographics, headache features, migraine-related disability, depression (PHQ-9), anxiety (GAD-7), optimism, and pessimism (life orientation test -revised) was administered to people with migraine and headache-free control participants from the general population in São Paulo, Brazil via trained interviewers. Six hundred individuals were contacted. The odds for having migraine/ no headache diagnosis were calculated by binary logistic regression, and ordinal regression was performed to check associations between migraine-related disability and optimism.Results.-A total of 302 individuals (mean ± SD age: 39.7 ± 12.7; BMI: 26.5 ± 5.9) met inclusion criteria and were included, 140 controls (with no history of headache disorders) and 162 people meeting criteria for migraine (29 with chronic migraine, that is, 15 or more headache days/month). People with migraine were less optimistic and more pessimistic than controls, and endorsed higher levels of anxious and depressive symptoms. Pessimism (OR 95% CI = 1.16 [1.05-1.28], P = .005) and anxiety (OR 95% CI = 1.19 [1.10-1.29], P < .001) were predictors of meeting criteria for migraine, while optimism (β 95% CI = −0.915 [−1.643, −0.188], P = .01) was inversely associated with migraine-related disability.Conclusions.-Optimism and pessimism are associated with migraine and migraine-related disability. These concepts should be further explored in people with migraine with regard to their potential influences on clinical research outcomes and treatments.

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Anxiety and depression symptoms and migraine: a symptom-based approach research

Cited by 163 publications

References 36 publications

Exercise-Induced Change in Plasma IL-12p70 Is Linked to Migraine Prevention and Anxiolytic Effects in Treatment-Naïve Women: A Randomized Controlled Trial

Exercise-Induced Change in Plasma IL-12p70 Is Linked to Migraine Prevention and Anxiolytic Effects in Treatment-Naïve Women: A Randomized Controlled Trial

Unhealthy Mental States Are Positively Associated with Subjective Pain or Fatigue in Specific Body Sites among High School Teachers in Japan

Optimism, Pessimism, and Migraine: A Cross‐Sectional, Population‐Based Study

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