Anxiety and Depression in Young Women With Metastatic Breast Cancer: A Cross-Sectional Study

Park, Eliza M.; Gelber, Shari; Rosenberg, Shoshana M.; Seah, Davinia; Schapira, Lidia; Come, Steven E.; Partridge, Ann H.

doi:10.1016/j.psym.2018.01.007

Cited by 122 publications

(105 citation statements)

References 36 publications

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“…In a study conducted by Alizadeh et al on women with breast cancer, the results showed that selfcompassion was at a moderate level in the studied sample, which corroborates our results (14). In the study by Park et al, although anxiety symptoms were highly experienced by young women with newly diagnosed metastatic breast cancer, depression was less common (15).…”

Section: Discussionmentioning

confidence: 92%

Relationship Between Self-Compassion and Depression in Cancer Patients Referring to the Oncology Ward of Shahid Baghaee Hospital in Ahvaz, Iran

Madmoli

Gheibizadeh

Fazeli

et al. 2019

Jundishapur J Chronic Dis Care

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Background: Depression is one of the most common psychiatric diseases in cancer patients. Few studies showed that selfcompassion is a reliable predictor of mental health. Objectives: This study aimed to determine the relationship between self-compassion and depression in cancer patients referring to the Oncology Ward of Shahid Baghaee Hospital in Ahvaz. Methods: This correlational study was conducted on 106 eligible adult cancer patients who referred to the Oncology Ward of Shahid Baghaee Hospital in Ahvaz. The patients were chosen using convenience sampling. Data were collected by a demographic questionnaire, the Beck depression scale, and the self-compassion scale (SCS-LF). Data were analyzed by SPSS 20 using descriptive statistics and Pearson's correlation coefficient. Results: This study recruited 106 cancer patients with a mean age of 41.14 ± 15.12 years. The majority of the subjects were male (61.3%), married (65.1%), and urban residents (68.9%). Chemotherapy was the most used treatment in these patients (70.8%). The mean scores of self-compassion and depression were 3.2 ± 0.41 and 19.87 ± 12.55, respectively. These results indicated a moderate level of selfcompassion and a high level of depression in the patients. There was a significant negative correlation between self-compassion and depression (P < 0.05). Conclusions: As the results of the present study indicated the high prevalence of depression in the studied patients and a negative relationship between depression and self-compassion, it is necessary to perform psychological interventions with an emphasis on compassion component to reduce depression in these patients.

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Section: Discussionmentioning

confidence: 92%

Relationship Between Self-Compassion and Depression in Cancer Patients Referring to the Oncology Ward of Shahid Baghaee Hospital in Ahvaz, Iran

Madmoli

Gheibizadeh

Fazeli

et al. 2019

Jundishapur J Chronic Dis Care

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“…In our investigation, we focused on major depression in early and metastatic breast cancer, the patients with metastatic breast cancer seriously suffered from major depression and the ratio of major depression was highlighted. Depression, linked to both the psychological aspects of society relationship and the physical effects of chemotherapy, which always can be overwhelming during metastatic treatment [26]. Longer-term ovarian function administration of a GnRH agonist was complicated assessed whereas the combination of adjuvant endocrine therapy and ovarian function suppression with synchronous or sequential chemotherapy.…”

Section: Discussionmentioning

confidence: 99%

Depression, Sexual dysfunction and Quality of Life Among Breast Cancer Patients with Ovarian Function Suppression: A Cross Sectional Study between Ovarian Ablation Verse GnRH Agonists

Jiang

Cai

et al. 2020

Preprint

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Background: Ovarian function suppression is being widely utilized as endocrine therapy to reduce estrogen release in premenopausal breast cancer patients and was achieved either by medical treatment with bilateral oophorectomy, irradiation, or the Gonadotropin releasing hormone (GnRH) agonist. This study aimed to examine whether GnRHa differed from ovarian ablation on depression, sexual dysfunction and quality of life.Methods: The premenopausal breast cancer patients who received ovarian function suppression were enrolled from seven hospital between June 2019 and June 2020. Our independent variable was the type of ovarian suppression, categorized as Ovarian Ablation (OA cohort, n=174) and medical GnRH agonist (GnRHa cohort, n=389). The self-administered questionnaire (OFS-Q5) was developed and used in this study aimed to assess the depression (PHQ-9), sexual dysfunction (FSFI) and quality of life (EORTC QLQ-BR23).Results: In this cross-sectional study, 563 patients with ovarian function suppression completed surveys were collected. The mean sum score of the PHQ-9 tend to be slight decrease in GnRHa cohort than that in ovarian ablation (OA) cohort (11.4 ±5.7 vs. 12.8 ±5.8, OR=1.910, P=0.079). Patients with major depression (PHQ-9≧15) was indicated significantly fewer in GnRHa cohort (31.1% vs 40.2%, P=0.025). The more surprising correlation is less patients with sexual dysfunction (61.5%, FSFI< 23) in OA cohort, a remarkable increase in GnRHa cohort (72.2%, P = 0.011). The ratio of sexual dysfunction remained lower for ovarian ablation women in long-term ovarian suppression (duration of ovarian suppression > 2 years: OA vs GnRHa, OR=1.555, P=0.037). No significantly difference for most subscales of QLQ-BR23 between two cohorts was evident.Conclusions: Our current investigation demonstrate here for the first time that medical GnRHa resulted in favour depression, worse sexual function than those with ovarian ablation, with similar quality of life. This new understanding should help to improve and alleviate adverse effect in patients with diverse ovarian function suppression.

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“…Despite the increasing prevalence of MBC in young women, limited research has evaluated their psychological distress at diagnosis. A recent study has revealed anxiety as the most clinically prevalent psychological problem in young women with de novo MBC [ 12 ]. The prevalence of clinically significant anxiety and depression symptom burden in this population was 44% and 20%, respectively, exceeding rates observed in mixed-age populations [ 12 ].…”

Section: Coping With the Diagnosis Of Mbc In Young Womenmentioning

confidence: 99%

Psychosocial aspects and life project disruption in young women diagnosed with metastatic hormone-sensitive HER2-negative breast cancer

et al. 2020

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Metastatic breast cancer (MBC) diagnosis in young women negatively impacts on quality of life (QoL) and daily activities, disrupting their life project and forcing them to face new psychosocial challenges. The recently published results on the improvement of the overall survival of pre- or perimenopausal women with hormone-receptor-positive, HER2-negative MBC treated with CDK4/6 inhibitors plus endocrine therapy, while preserving, and in some items improving their QoL, will change the landscape of the management of this patient population. Their extended survival and potential improvement in QoL will, therefore, modify their specific needs in terms of psychosocial support. The complexity of the care of young women with MBC is described herein, based on an extensive literature review. Further research about the specific psychosocial requirements of these women and a new multidisciplinary holistic approach is paramount to properly address their concerns and preferences. The communication with and support of their partners, parents and children is an important factor affecting the QoL of these patients. Altogether, a multidisciplinary care, open communication and personalized support is required to address the psychosocial implications of the new prognostic expectations on these patients with the incorporation of new targeted therapies.

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Anxiety and Depression in Young Women With Metastatic Breast Cancer: A Cross-Sectional Study

Cited by 122 publications

References 36 publications

Relationship Between Self-Compassion and Depression in Cancer Patients Referring to the Oncology Ward of Shahid Baghaee Hospital in Ahvaz, Iran

Relationship Between Self-Compassion and Depression in Cancer Patients Referring to the Oncology Ward of Shahid Baghaee Hospital in Ahvaz, Iran

Depression, Sexual dysfunction and Quality of Life Among Breast Cancer Patients with Ovarian Function Suppression: A Cross Sectional Study between Ovarian Ablation Verse GnRH Agonists

Psychosocial aspects and life project disruption in young women diagnosed with metastatic hormone-sensitive HER2-negative breast cancer

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