Anxiety and Depression in Pediatric Patients with Celiac Disease: A Large Cross-Sectional Study

Germone, Monique; Phu, Tiffany; Slosky, Camryn; Pan, Zhaoxing; Jones, Anna; Stahl, Marisa G.; Mehta, Pooja; Shull, Mary; Ariefdjohan, Merlin; Liu, Edwin

doi:10.1097/mpg.0000000000003497

Cited by 11 publications

(6 citation statements)

References 21 publications

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“…This is not surprising as rectal bleeding is one of the main symptoms of IBD [28] and Food and Drink Limits in children with CeD are evident as the GFD is restrictive. Similar to our ndings, previous studies have described impaired Emotional Functioning in children with CeD, with a high prevalence of anxiety and depressive symptoms [30]. On the one hand, Emotional Functioning may be impaired due to intrinsic depressive symptoms and anxiety that can occur from untreated CeD [31].…”

Section: Discussionsupporting

confidence: 89%

Comparison of Quality of Life between Children and Adolescents with Coeliac Disease and Inflammatory Bowel Disease – A Survey among Patients and Their Caregivers

Broekaert

Hünseler

2023

Preprint

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Purpose: The aim was to evaluate quality of life (QoL) in paediatric coeliac disease (CeD) and inflammatory bowel disease (IBD) patients and determine factors contributing to QoL. Methods: Children (3–18 years) with either CeD or IBD and their parents filled in two questionnaires: the PedsQL™ 4.0 SF 15 (SF 15) and the PedsQL™ 3.0 GIS Scale (GIS). The scores were compared and correlated with clinical data. Results: 220 participants were enrolled (CeD: n = 67; IBD: n = 52). QoL in children with CeD or IBD are comparable between total scores (SF 15 total score: 83.49 (CeD) vs. 85.39 (IBD) (p = 0.13); GIS total score: 83.95 (CeD) vs. 88.25 (IBD) (p = 0.09)). However, differences in subcategories were found. In CeD patients, Emotional Functioning (p = 0.04), Food and Drink Limits (p < 0.01), Trouble Swallowing (p = 0.02) and Heart Burn and Reflux (p < 0.01) were related to a poorer QoL. Comparing perceptions of parents, similar results of QoL were shown (CeD: Emotional Functioning (p = 0.02), Food and Drink Limits (p < 0.01); IBD: Blood in Poop scale (p < 0.01)). According to univariate regression, SF 15 total scores of children with IBD and their parents (p < 0.01) and GIS total scores (children: p < 0.03, parents: p < 0.01) were lower when calprotectin was elevated. Total SF 15 scores reported by parents of children with CeD were lower when transglutaminase-IgA was elevated (p = 0.02). Conclusions: Although both diseases may vary in their clinical appearance and limitations in daily life, perceptions of QoL are comparable to each other. Yet, we discovered disease specific domains contributing to a lower QoL. Trial Registration: Bfarm.de; German Clinical Trials Register ID DRKS00027418; Trial registered on February 10th, 2022.

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Section: Discussionsupporting

confidence: 89%

Comparison of Quality of Life between Children and Adolescents with Coeliac Disease and Inflammatory Bowel Disease – A Survey among Patients and Their Caregivers

Broekaert

Hünseler

2023

Preprint

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“…There was a statistically significant difference between the rates of anxiety and depression symptoms reported by children with and without other medical comorbidities (P = 0.04). Accordingly, it is important to frequently assess pediatric patients with CD for mental health issues, especially anxiety and sadness [37]. Researchers conducted a detailed survey and analysis to discover how often celiacs experience anxiety and depression and how these symptoms are linked to psycho-affective, familial, and lifestyle factors.…”

Section: Depression and Anxietymentioning

confidence: 99%

Psychiatric and Neurological Manifestations of Celiac Disease in Adults

Alkhiari¹

2023

Cureus

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Celiac disease (CD), a chronic inflammatory disorder of the intestines, affects 0.7% to 1.4% of the world's population. CD causes diarrhea, abdominal discomfort, bloating, flatulence, and, in rare cases, constipation in the digestive tract. Since the identification of gluten as the disease-causing antigen, CD patients have been treated with a gluten-free diet, which is advantageous but has limitations for certain patient groups. CD is associated with mood disorders, such as manic-depressive disease, schizophrenia, and bipolar disorder, as well as other disorders such as depression and anxiety. The relationship between CD and psychological issues is not entirely understood. Here, we look at the most recent psychiatric data as they pertain to CD, as well as the relevant psychiatric manifestations that have been associated with this condition. Clinicians should examine mental health factors when a CD diagnosis is established. More research is needed to understand the pathophysiology of CD's psychiatric manifestations.

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“…Anxiety and depression symptom rates were evaluated in 175 children with celiac disease (ages 8–17 years) using the Revised Children’s Anxiety and Depression Scale (RCADS) (median = 1.1 years post‐diagnosis, IQR = 0–4). Self‐reported RCADS scores showed 39% of children having clinically significant concerns for anxiety or depression ( P < 0.0001) but only 7% of caregiver‐proxy RCADS scores indicated significant concerns for the child’s anxiety and 14% for the child’s depression (27). Rates of child‐reported anxiety and depression symptoms were significantly higher for those without medical comorbidities than those with ( P = 0.04).…”

Section: Selected Publications From Jpgn In 2022mentioning

confidence: 99%