Anxiety and Depression in Diabetic Patients

Oğuz, Nihan

doi:10.14744/ejmi.2018.46220

Cited by 5 publications

(4 citation statements)

References 20 publications

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“…Regarding the prevalence of depression and anxiety, we found that 9% of the participants screened positive for anxiety and 20% met criteria for depression. The prevalence of depression reported in our study was similar to that reported in previous studies, where prevalence was estimated between 18 and 30% [25]. The prevalence of anxiety among participants in our study was relatively low compared to the prevalence reported by the INTERPRET-DD study, which estimated the prevalence of anxiety (all anxiety disorder included) to be 18% based on data collected from 3170 diabetic patients from 15 countries in different continents [26].…”

Section: Discussionsupporting

confidence: 86%

Depression, anxiety, and associated factors in patients with diabetes: evidence from the anxiety, depression, and personality traits in diabetes mellitus (ADAPT-DM) study

et al. 2020

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Background: Depression and anxiety are common psychiatric complications affecting patients with diabetes mellitus. However, data on the prevalence of depression, anxiety, and associated factors among Malaysian diabetic patients is scarce. The Anxiety, Depression, and Personality Traits in Diabetes Mellitus (ADAPT-DM) study aimed to determine the prevalence of depression and anxiety, and their associated factors in the Malaysian diabetic population. Methods: This cross-sectional study recruited 300 diabetic patients via convenience sampling from the Endocrine outpatient clinic of Universiti Kebangsaan Malaysia Medical Centre, a tertiary referral healthcare facility in Kuala Lumpur. Socio-demographic characteristics and clinical history were obtained from each participant. The Generalised Anxiety Disorder-7 (GAD-7) was administered to assess anxiety symptoms, the Beck Depression Inventory (BDI) to assess depressive symptoms, the Big Five Inventory (BFI) to evaluate personality traits, and the World Health Organization Quality of Life-BREF (WHOQOL-BREF) to measure quality of life (QOL). Stepwise multiple logistic regression analyses were performed to determine the association between various factors, and depression and anxiety.

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Section: Discussionsupporting

confidence: 86%

Depression, anxiety, and associated factors in patients with diabetes: evidence from the anxiety, depression, and personality traits in diabetes mellitus (ADAPT-DM) study

et al. 2020

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“…Regarding the prevalence of depression and anxiety, we found that 9% of the participants screened positive for anxiety and 20% met criteria for depression. The prevalence of depression reported in our study was similar to that reported in previous studies, where prevalence was estimated between 18% and 30% [23]. The prevalence of anxiety among participants in our study was relatively low compared to the prevalence reported by the INTERPRET-DD study, which estimated the prevalence of anxiety (all anxiety disorder included) to be 18% based on data collected from 3170 diabetic patients from 15 countries in different continents [24].…”

Section: Here] Multivariate Logistic Regression Analyses Between Varisupporting

confidence: 86%

Depression, anxiety, and associated factors in patients with diabetes: evidence from the Anxiety, Depression, and Personality Traits in Diabetes Mellitus (ADAPT-DM) study

Abdullah

Woon

Sidi

et al. 2020

Preprint

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Background Depression and anxiety are common psychiatric complications affecting patients with diabetes mellitus. However, data on the prevalence of depression, anxiety, and associated factors among Malaysian diabetic patients is scarce. The Anxiety, Depression, and Personality Traits in Diabetes Mellitus (ADAPT-DM) study aimed to determine the prevalence of depression and anxiety, and their associated factors in the Malaysian diabetic population. Methods This cross-sectional study recruited 300 diabetic patients via convenience sampling from the Endocrine outpatient clinic of Universiti Kebangsaan Malaysia Medical Centre, a tertiary referral healthcare facility in Kuala Lumpur. Socio-demographic characteristics and clinical history were obtained from each participant. The Generalised Anxiety Disorder-7 (GAD-7) was administered to assess anxiety symptoms, the Beck Depression Inventory (BDI) to assess depressive symptoms, the Big Five Inventory (BFI) to evaluate personality traits, and the World Health Organization Quality of Life-BREF (WHOQOL-BREF) to measure quality of life (QOL). Multivariate logistic regression analyses were performed to determine the association between various factors, and depression and anxiety. Results The prevalence of depression was 20% (n = 60) while anxiety was 9% (n = 27). Co-morbid depression (adjusted OR = 24.91, 95% CI = 5.67–109.42, p < 0.001), neuroticism (adjusted OR = 9.24, 95% CI = 2.03–42.03, p = 0.004), and greater physical health-related QOL (adjusted OR = 1.67, 95% CI = 1.07–2.59, p = 0.024) increased the odds of developing anxiety, while psychological QOL (adjusted OR = 0.41, 95% CI = 0.21–0.79, p = 0.008) was protective. Co-morbid anxiety (adjusted OR = 20.06, 95% CI = 4.70–85.57, p < 0.001) increased the odds of depression, while older age (adjusted OR = 0.96, 95% CI = 0.92–0.99, p = 0.012), regular religious practice (adjusted OR= 0.08, 95% CI= 0.01-0.56, p= 0.011) and physical health-related QOL (adjusted OR = 0.72, 95% CI = 0.59–0.89, p = 0.002) were protective. Conclusions The study findings signify the need to screen for co-morbid depression and anxiety, as well as personality traits and QOL, and to include psychosocial interventions when planning a multidisciplinary approach to managing diabetes.

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“…For this reason, many experimental animal studies are carried out for this purpose, but a clear answer has not been found yet, so it is thought that more comprehensive studies are needed in this area. 1,2,36…”

Section: Discussionmentioning

confidence: 99%

The effects of donepezil on anxiety- and depression-like behaviors in diabetic rats and the role of nitric oxide modulators

ÖZ>¹,

Atalık²,

Aslanlar³

2023

KMJ

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Aims: The aim of the present study was to evaluate the effect of an acetylcholinesterase inhibitor donepezil on the diabetes-induced anxiety and depression and the role of nitric oxide in these effects. Methods: Thirty male Wistar rats were randomly divided into 2 groups at first; the control group (n=6) and the diabetic group (n=24). The diabetic group divided into four groups, a single dose of streptozotocin was used to induce experimental type 1 diabetes. After 30 days, one group was separated as diabetic control, while the other three received 4 mg/kg p.o. donepezil for 20 days. One of the DON groups was administered 20 mg/kg i.p., L-NAME for 20 days, while the other group was administered 40 mg/kg i.p., L-arginine for 20 days. Results: Anxiety-like behaviors were assessed using the open field test (OFT), and depression-like behaviors were estimated using the forced swim test (FST). In the OFT, all diabetic rats spent less time in the center and engaged in less exploratory behavior than the control group. The number of lines crossed where locomotor activity was assessed did not differ significantly between groups. In the FST, duration of immobility increased significantly in diabetic groups compared to the control. Donepezil administration did not affect either depression or anxiety responses. Moreover, donepezil plus L-arginine increased diabetes-induced depression significantly. Conclusion: These findings may suggest that cholinergic and nitrergic systems may interact on depression-like behaviors in diabetic rats.

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Anxiety and Depression in Diabetic Patients

Abstract: D iabetes mellitus (Diabetes) is a chronic metabolic dis

Cited by 5 publications

References 20 publications

Depression, anxiety, and associated factors in patients with diabetes: evidence from the anxiety, depression, and personality traits in diabetes mellitus (ADAPT-DM) study

Depression, anxiety, and associated factors in patients with diabetes: evidence from the anxiety, depression, and personality traits in diabetes mellitus (ADAPT-DM) study

Depression, anxiety, and associated factors in patients with diabetes: evidence from the Anxiety, Depression, and Personality Traits in Diabetes Mellitus (ADAPT-DM) study

The effects of donepezil on anxiety- and depression-like behaviors in diabetic rats and the role of nitric oxide modulators

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