Anxiety

Brandt, Christian

doi:10.1007/978-3-319-22159-5_4

Cited by 2 publications

(2 citation statements)

References 81 publications

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“…They also merit attention because of special implications for treatment and specific pathophysiological considerations. Whilst psychoses and depressive disorders have found attention since several years, it is only in recent years that anxiety disorders find the attention they deserve (Brandt, 2016). Anxiety disorders are even called the "forgotten comorbidity" (Kanner, 2011).…”

Section: Introductionmentioning

confidence: 99%

Anxiety disorders in people with epilepsy

Brandt¹,

Mula

2016

Epilepsy & Behavior

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Anxiety disorders are frequent, though probably underdiagnosed comorbidities in epilepsy.Epilepsy and anxiety may share common neurobiological correlates as shown in animal models and suggested by studies demonstrating anxiety disorders before the manifestation of epilepsy. Comorbid anxiety disorders have a major impact on the affected patients' qualityof-life and may increase the risk for suicidality. Successful treatment of the epilepsy may alleviate anxiety symptoms. Treatment of anxiety is based on selective serotonin reuptake inhibitors, benzodiazepines (although only further choice) and psychotherapy. Specific AEDs (especially pregabalin) have been shown to have anxiolytic properties. This paper is aimed at reviewing anxiety disorders in patients with epilepsy discussing current scientific evidence about pathophysiology, clinical aspects and treatment strategies.

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Section: Introductionmentioning

confidence: 99%

Anxiety disorders in people with epilepsy

Brandt¹,

Mula

2016

Epilepsy & Behavior

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“…The meta-analysis by Scott et al (2020) also found that shorter epilepsy duration was associated with a lower prevalence of depressive and anxiety disorders in young people with epilepsy. Brandt (2016) , however, found that younger patients with a shorter epilepsy duration were more likely to have anxiety disorders, underlying that an adaptation period is required to develop coping strategies for the stressful situation. These results suggest that there is an interrelationship between epilepsy duration and negative affectivity, and these variables may influence cognition and QOL.…”

Section: Introductionmentioning

confidence: 99%

Stress phenotypes in epilepsy: impact on cognitive functioning and quality of life

Catalán-Aguilar,

González-Bono,

Lozano-García

et al. 2023

Front. Psychol.

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IntroductionDrug-resistant epilepsy has been proposed as a chronic stress model. Stress can be measured in terms of chronicity (epilepsy duration) and intensity (comorbidities), with depression and anxiety among the most important comorbidities in epilepsy due to its prevalence and its relationship with cognitive functioning and quality of life. This study aims to establish phenotypes according to how patients face a stressful condition (epilepsy) and examine differences in cognition and quality of life depending on these phenotypes. We hypothesize that there will be an interrelationship between epilepsy duration and negative affectivity, and these variables will influence cognition and quality of life.Methods170 patients (82 men and 88 women) underwent a neuropsychological evaluation in which trait anxiety, depression, attention and executive function, verbal and visual memory, language, emotional recognition, and quality of life were assessed. Hierarchical clustering was performed using z-scores for three variables: trait anxiety; depression; and epilepsy duration.ResultsThree clusters were found: vulnerable (high negative affectivity and short duration); resilient (moderate negative affectivity and long duration); and low-impact group (low negative affectivity and short duration). Results show that the vulnerable group had poorer cognitive functioning and quality of life than the other groups. Specifically, the vulnerable group had poorer scores than the low-impact group on verbal memory, visual confrontation naming, and quality of life (except seizure worry). Furthermore, resilient patients had better scores than the low-impact group on cognitive flexibility variables, but lower scores on some quality-of-life subscales (i.e., overall quality of life, emotional well-being, and energy). Finally, the vulnerable group had poorer scores than the resilient group in executive functioning, naming, and quality of life.DiscussionThese results suggest that dealing with stress in patients with epilepsy is related to cognitive performance and quality of life. These findings underline the relevance of considering comorbidities in epilepsy and may be useful for detecting vulnerable or resilient profiles as risk or protective factors for cognitive and quality of life decline.

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Anxiety

Cited by 2 publications

References 81 publications

Anxiety disorders in people with epilepsy

Anxiety disorders in people with epilepsy

Stress phenotypes in epilepsy: impact on cognitive functioning and quality of life

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