Anurea caused by primary amyloidosis of the lower third of the ureters, the ureterovesical junction and the urinary bladder

Paraskevas, Kosmas I.; Anagnostou, Dimitris; Bouris, Christos

doi:10.1007/s11255-004-0931-0

Cited by 5 publications

(5 citation statements)

References 14 publications

(20 reference statements)

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“…Two of the patients also complained of flank pain, and all had hydronephrosis at the time of presentation. These features of ureteral obstruction are consistent with the reported literature on upper tract amyloidosis [6][7][8][9]11,12 and, of course, can also be seen with neoplasm. Severe irritative symptoms are common in patients with bladder amyloidosis, 2,3 but these were characteristically absent in our three patients with upper urinary tract amyloidosis.…”

Section: Discussionsupporting

confidence: 90%

Localized Amyloidosis of the Upper Urinary Tract: A Case Series of Three Patients Managed with Reconstructive Surgery or Surveillance

Borza

Shah

Faerber

et al. 2010

Journal of Endourology

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Primary localized amyloidosis of the upper urinary tract is a rare condition that is of interest because the clinical presentation and radiographic and endoscopic appearance mimic malignancy. Many commonalities exist between upper urinary tract and bladder amyloidosis, but obstructive features, like flank pain and hydronephrosis, are unique to upper urinary tract lesions. In the absence of significant obstruction, early eradication of an upper urinary tract lesion may not be necessary. Rather, follow-up with serial imaging is sufficient to monitor for disease progression.

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Section: Discussionsupporting

confidence: 90%

Localized Amyloidosis of the Upper Urinary Tract: A Case Series of Three Patients Managed with Reconstructive Surgery or Surveillance

Borza

Shah

Faerber

et al. 2010

Journal of Endourology

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“…Various treatments for localized amyloidosis have been employed including fulguration, laser therapy and intravesical dimethyl sulphoxide which acts to increase amyloid solubility [4,17,20]. Larger, more diffuse lesions are seen in approximately 10% of cases and may require transurethral resection or, in rare cases, partial cystectomy [4].…”

Section: Resultsmentioning

confidence: 99%

“…Associated inflammation and giant cell reaction are a common nonspecific finding [10]. The presence of amyloidosis in the urinary tract is uncommon with less than 200 reported cases, and its presence in voided urine cytopathology has, to date, not been described [1,3,4,16,17,18,19,20,21]. We report a series of 3 cases of isolated bladder amyloidosis with corresponding urine specimens.…”

Section: Introductionmentioning

confidence: 99%

Urinary Cytopathology in Primary Bladder Amyloidosis

Toll

Ali²

2013

Acta Cytologica

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Background: Amyloidosis results from the accumulation of unique extracellular proteins which are not able to be degraded via the usual mechanism of lysosomal proteolysis. Isolated collections of amyloid within the bladder are extremely uncommon, and a cytopathologic description in voided urine has not been described to date. Methods: A retrospective review was performed at a tertiary-care hospital, and 3 patients with isolated bladder amyloidosis and corresponding voided urine specimens were identified. The following clinical data were collected for each case: age, gender, treatment and follow-up information. Results: The patient age range was 76-84 years, with 2 males and 1 female. Amyloidosis was never clinically suspected. In 1 patient, a urinary amyloid manifested, which was thought to represent extraneous debris at the time of original diagnosis. Two patients never manifested signs of systemic amyloidosis or multiple myeloma, and the third was found to have a monoclonal gammopathy. Conclusions: Our results show the difficulty of diagnosing urinary amyloid in the absence of clinical suspicion. Further, the presence of urinary amyloid is unlikely in patients with bladder amyloidosis as the cohesive nature of the protein makes spontaneous shedding uncommon. Testing for systemic amyloidosis is warranted and if the disease is localized, a favorable outcome can be expected.

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“…Although benign, bladder amyloidosis can progressively lead to upper urinary tract obstruction 12 and can even affect both ureterovesical junctions, causing anuria. 13 Therefore, in patients with upper urinary tract obstruction, surgical intervention is appropriate and necessary. In the absence of significant obstruction, however, early surgical intervention may not be necessary.…”

Section: Discussionmentioning

confidence: 99%

Spontaneous remission of untreated primary amyloidosis of the bladder after transurethral resection biopsy: a case report and literature review

Jia

Liu

2020

J Int Med Res

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We herein present a case involving a 23-year-old woman with gross hematuria. Cystoscopy revealed abnormal areas of the mucosa along the anterior and posterior bladder walls. These abnormalities were suspicious for neoplasia; however, a diagnosis was not established by subsequent biopsy. The patient underwent transurethral resection biopsy in which an isolated lesion along the anterior wall was completely resected and the others were left untreated. Pathologic examination and special staining led to a diagnosis of amyloidosis, and the patient elected to undergo transurethral surgery 1 month later. During the operation, the intravesical lesions were found to have significantly improved in both the treated and untreated sites. The operation was cancelled, follow-up was arranged, and no other treatment was administered. Repeat cystoscopy examinations at 3 and 9 months after surgery showed that the lesions had almost completely disappeared.

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Anurea caused by primary amyloidosis of the lower third of the ureters, the ureterovesical junction and the urinary bladder

Cited by 5 publications

References 14 publications

Localized Amyloidosis of the Upper Urinary Tract: A Case Series of Three Patients Managed with Reconstructive Surgery or Surveillance

Localized Amyloidosis of the Upper Urinary Tract: A Case Series of Three Patients Managed with Reconstructive Surgery or Surveillance

Urinary Cytopathology in Primary Bladder Amyloidosis

Spontaneous remission of untreated primary amyloidosis of the bladder after transurethral resection biopsy: a case report and literature review

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