Antroquinonol inhibits NSCLC proliferation by altering PI3K/mTOR proteins and miRNA expression profiles

Antroquinonol from Antrodia Camphorata suppresses breast tumor migration/invasion through inhibiting ERK-AP-1- and AKT-NF-κB-dependent MMP-9 and epithelial-mesenchymal transition expressions

“…ANQ inhibits lipopolysaccharide-elicited inducible nitric oxide synthase (iNOS) expression and NO production in murine macrophages, and suppresses renal inflammation through Nrf2 activation and reactive oxygen species reduction (Yang et al, 2013b). In addition, ANQ induces apoptosis and autophagy in pancreatic cancer cells through inhibiting PI3K/AKT/mTOR signaling cascade (Yu et al, 2012), and suppresses the growth of hepatoma and lung cancer cells by modulating the PI3K/mTOR activation (Chiang et al, 2010;Kumar et al, 2011). These data suggest that PI3K/AKT may be the target of ANQ.…”

“…ANQ was reported to have antitumor effects in hepatomas, pancreatic cancer, and lung cancer. Previous studies revealed that ANQ induces apoptosis and autophagy in pancreatic cancer cells (Yu et al, 2012), and modulates AMPK or PI3K/mammalian target of rapamycin (mTOR) signaling in hepatomas and lung cancer, leading to inhibited cell proliferation (Chiang et al, 2010;Kumar et al, 2011). However, the effect of ANQ on breast cancer is still unknown.…”

Induction of antroquinonol production by addition of hydrogen peroxide in the fermentation ofAntrodia camphorataS-29

“…Many results showed that antroquinonol has significant anti‐tumour effects on various cancer cells, including breast cancer, liver cancer and prostate cancer . Kumar et al illustrated that antroquinonol significantly inhibited the proliferation of three kinds of non‐small cell lung cancer (NSCLS) cancer cells by changing the protein activity and mRNA expression of PI3K/mTOR. Ho et al found that antroquinonol can inhibite Ras and Ras‐related small GTP‐binding protein functions through the inhibition of protein isoprenyl transferase activity in cancer cells.…”

Anti-cancer agents derived from solid-state fermented Antrodia camphorata mycelium

“…The extract of this fungus has been shown to inhibit inflammation, viral infection, oxidative stress, atherosclerosis, and the growth of several types of cancer cells [4][5][6]. Previous studies have shown that antroquinonol, a ubiquinone derivative found in the mycelium of A. camphorata, inhibits the growth of hepatocellular carcinoma (HCC) cells through the activation of AMPK and the inhibition of mTOR signaling [7], and the proliferation of NSCLC by altering PI3K/ mTOR proteins and miRNA expression profiles [8], and induces apoptosis and senescence in human pancreatic carcinoma cells Fitoterapia 102 (2015) 115-119 [9]. The fungus has also been shown to inhibit iNOS activity and reduce oxidative stress through Nrf-2 activation [10][11][12].…”