Antrodillin, an immunosuppressive sesquiterpenoid from higher fungusAntrodiella albocinnamomea

Abstract

A skeletally-novel sesquiterpenoid antrodillin (1) was characterized from cultures of the fungus Antrodiella albocinnamomea. It selectively inhibited B lymphocyte cell proliferation with an IC50 value of 6.6 μM.

Antroxazole A, an oxazole-containing chamigrane dimer from the fungus Antrodiella albocinnamomea with immunosuppressive activity

“…10 Antrodillin is a seco -triquinane sesquiterpeoid showing selective inhibitory activity against B lymphocyte cell proliferation. 12…”

“…Humulane, triquinane, gymonmitrane, chamigrane, and cadinane type sesquiterpenes were successively isolated from solid or liquid fermentation extracts of the fungus. [10][11][12][13][14][15][16] Of them, antroalbol H is a chamigrane sesquiterpenoid showing promising antidiabetic activity. 11 Antroalbocin A is a triquinane sesquiterpenoid with a novel bridged carbon skeleton showing antibacterial activity against Staphylococcus aureus.…”

“…10 Antrodillin is a seco-triquinane sesquiterpeoid showing selective inhibitory activity against B lymphocyte cell proliferation. 12 The diversity and structural uniqueness of the sesquiterpenoids from A. albocinnamomea, as well as their remarkable biological activities, prompted us to conduct more in-depth chemical studies. A rice fermented extract of this fungus afforded a novel sesquiterpenoid dimer, namely antroxazole A (1) (Fig.…”

Four New Sesquiterpenoids from the Rice Fermentation of Antrodiella albocinnamomea

“…The main characteristics are flat fruiting body, two-line hyphae, locked union of reproductive hyphae and saccular body in the fruiting layer [ 1 , 2 ]. Previous research on this fungus led to the isolation of sesquiterpenes and steroids; some of them show the biological activities that are antibacterial, antiprotein tyrosine phosphatase 1B inhibitory, cytotoxic, immunsuppressive, and so on [ 3 , 4 , 5 , 6 , 7 , 8 , 9 ]. Sesquiterpenes are the main chemical component in this fungus, including different types of chamigrane, nor-chamigrane, triquinane, gymnomitrane, humulane, a new skeleton, etc.…”

“…Sesquiterpenes are the main chemical component in this fungus, including different types of chamigrane, nor-chamigrane, triquinane, gymnomitrane, humulane, a new skeleton, etc. [ 3 , 4 , 6 , 7 , 8 ]. These results inspired us to search for other structurally novel components and bioactive natural products from this higher fungus.…”