Antral nodularity identifies children infected with Helicobacter pylori with higher grades of gastric inflammation

Luzza, Francesco; Pensabene, Licia; Imeneo, Maria; Mancuso, M; Contaldo, A; Giancotti, Luigino Antonio; Vecchia, Anna M. La; Costa, Maria C.; Strisciuglio, Pietro; Docimo, C; Pallone, Francesco; Guandalini, Stefano

doi:10.1067/mge.2001.111043

Cited by 43 publications

(44 citation statements)

References 20 publications

(21 reference statements)

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“…The prevalence of H. pylori infection was particularly high in our NG patients as reported in previous studies [3,11,24] . Likewise, the specificity and positive predictive value of NG for H. pylori infection were high, which confirmed the findings of other investigators [6,9,11] .…”

Section: Discussionsupporting

confidence: 63%

Endoscopic Nodular Gastritis in Dyspeptic Adults: Prevalence and Association with <i>Helicobacter pylori</i> Infection

Alenezi¹,

Alsurayei²,

Aly

et al. 2009

Med Princ Pract

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Objective: To determine the prevalence and histological features of endoscopic nodular gastritis (NG) in adult dyspeptic patients and its relation to Helicobacter pylori infection. Subjects and Methods: A retrospective endoscopic report review of 2,142 patients identified 67 patients with NG during the period from 1 September 2006 to 31 August 2007. A subset of 32 NG patients (group 1) who had had gastric biopsies during upper gastrointestinal endoscopy and had been evaluated for H. pylori infection were compared to 32 age- and gender-matched dyspeptic patients. They had undergone endoscopy during the same period, which yielded normal results, and had available biopsies that were similarly evaluated for H. pylori infection (controls, group 2). Pertinent clinical data were obtained from the patients’ records. An experienced pathologist assessed the biopsies for the presence and grade of inflammation, activity, glandular atrophy, intestinal metaplasia, presence and density of H. pylori and presence of lymphoid follicles or aggregates. Results: NG was identified in 67 (3.1%) patients. On histological examination, group 1 had a significantly higher grade of gastritis (p < 0.001). The presence and density of H. pylori infection was significantly higher in group 1 (p < 0.001). The H. pylori density correlated significantly with the severity of gastritis (r = 0.57, p < 0.001). The endoscopic performance of NG on H. pylori infection had high specificity (96.8%) and positive predictive value (93.3%). Conclusion: This study outlined the clinicopathological features of NG identified among a cohort of dyspeptic patients in Kuwait and confirmed the close association with H. pylori infection. However, our study has a limitation in that histopathologic assessment of all NG patients was not feasible.

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Section: Discussionsupporting

confidence: 63%

Endoscopic Nodular Gastritis in Dyspeptic Adults: Prevalence and Association with <i>Helicobacter pylori</i> Infection

Alenezi¹,

Alsurayei²,

Aly

et al. 2009

Med Princ Pract

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“…Kami juga menemukan nodularitas di duodenum yang sesuai dengan laporan kepustakaan bahwa nodularitas tersebut merupakan tanda kolonisasi HP dengan densitas tinggi. 14,15 Di RSAB Harapan Kita, biopsi diambil dari 3 tempat yaitu antrum pilori, duodenum, dan korpus gaster karena dengan cara ini angka positivitas HP yang didapat akan lebih tinggi sesuai dengan anjuran Megraud dkk. 16 Kami juga menemukan HP hanya dari biopsi korpus gaster pada satu kasus.…”

Section: Diskusiunclassified

Infeksi Helicobacter Pylori di RSAB Harapan Kita

Soelaeman

Purnomo

Merati

et al. 2016

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“…17,18 The association of NG with active chronic gastritis in children has been previously described by other authors. 5,11,15 On the other hand, few reports describe the histopathological characteristics of NG in adults. 19 We performed a cross-sectional study of young adults with H. pylori antibody or chronic abdominal pain to investigate the association of H. pylori infection with endoscopic NG and histological features of gastritis.…”

Section: Introductionmentioning

confidence: 99%

“…[1][2][3] Since the discovery of H. pylori by Marshall and Warren, 1 many studies have found a strong association between nodular gastritis (NG) and H. pylori infection in children. [4][5][6][7][8][9][10][11][12][13][14][15][16] However, the infl ammation of the gastric mucosa caused by H. pylori is not always observed macroscopically. This nodularity can be seen in the stomach of children much more frequently than in adults and may be a characteristic of an early stage of infection with H. pylori.…”

Section: Introductionmentioning

confidence: 99%

Nodular gastritis in Japanese young adults: endoscopic and histological observations

Shiotani

Kamada

Kumamoto³

et al. 2007

J Gastroenterol

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Antral nodularity identifies children infected with Helicobacter pylori with higher grades of gastric inflammation

Cited by 43 publications

References 20 publications

Endoscopic Nodular Gastritis in Dyspeptic Adults: Prevalence and Association with <i>Helicobacter pylori</i> Infection

Endoscopic Nodular Gastritis in Dyspeptic Adults: Prevalence and Association with <i>Helicobacter pylori</i> Infection

Infeksi Helicobacter Pylori di RSAB Harapan Kita

Nodular gastritis in Japanese young adults: endoscopic and histological observations

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