Antral motility measurements by magnetic resonance imaging

Marciani, Luca; Young, Paul; Wright, Jeff; Moore, Rachel J.; Coleman, Nicholas; Gowland, Penny A.; Spiller, Robin C.

doi:10.1046/j.1365-2982.2001.00285.x

Cited by 98 publications

(79 citation statements)

References 17 publications

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“…Based on a qualitative analysis of the experimental data, which show the development of a ring contraction with the narrowing of the lumen gut proximal to the metal bit, we can assume that it corresponds to the peak of the total force (1851 mN/cm) distribution observed in our results [4]. Our results fall in the range of experimentally measured velocity of the movement of intraluminal content (1-3 cm/s), which was observed in the studies of colonic motility in humans [8][9]. The model allows us to reproduce the effects of drugs affecting gut motility.…”

Section: Discussionsupporting

confidence: 53%

Modelling of the effects of Lotronex and Zelnorm on intestinal propulsion

Miftahof¹

2005

Modelling in Medicine and Biology VI

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A mathematical model of a segment of the gut to simulate propulsion of a solid pellet (bolus) under physiological conditions and after administration of the drugs -Lotronex (GSK) and Zelnorm (Novartis, AB) -is developed. The gut containing a pellet is represented as a thin deformable soft biological shell with the pellet modeled as a non-deformable solid. Mechanical properties of the gut wall satisfy the general type of nonlinear orthotropy and deformations are finite. Bolus propulsion is numerically simulated by generation and propagation of an electromechanical wave of excitation along the wall. Pharmacological manipulation is applied to model the effects of Lotronex and Zelnorm on the dynamics of bolus progression. The results lead to new quantitative insights into the complex spatio-temporal patterns of gastrointestinal transit. It is demonstrated that the reciprocal relationship in contraction of the longitudinal and circular smooth muscle syncytia is necessary to provide the "mixing" type of movements during the preparatory phase of propulsion. Strong simultaneous contractions of both smooth muscle layers are required to expel the "mixed" pellet from the segment. The model is implemented as an interactive software system, Gut Discovery ©, and accurately predicts the effects of drugs on gut motility.

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Section: Discussionsupporting

confidence: 53%

Modelling of the effects of Lotronex and Zelnorm on intestinal propulsion

Miftahof¹

2005

Modelling in Medicine and Biology VI

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“…This approach has been shown to be reliable and reproducible. 28 The high signal within the stomach in this sequence depends on paramagnetic contrast agent within the food ingested. In this study, we chose a pudding as the high caloric base for the oral contrast agent; in vitro experiments had revealed the pudding to be brightest following addition of a paramagnetic contrast in a concentration of 1:200.…”

Section: Discussionmentioning

confidence: 99%

Real time high resolution magnetic resonance imaging for the assessment of gastric motility disorders

Ajaj

2004

Gut

110

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Background: The aim of this study was to evaluate whether patients with increased or decreased gastric motility can be differentiated from healthy volunteers by means of real time magnetic resonance imaging (MRI). Patients and methods: Ten healthy volunteers, 10 patients with gastroparesis, and 10 patients with functional pylorospasm/peptic pyloric stenosis underwent real time MRI. All patients were examined on two separate days; once prior to therapy and once after adequate therapy. Antral motility was quantified by calculating the gastric motility index. Results: Patients with gastroparesis showed a lower motility index compared with the reference volunteer group while the mean motility index of the patient group with pylorospasm was more than three times higher than that of the reference value of the volunteer group. However, the gastric motility index in the patient group with gastroparesis increased, and in the group with functional pylorospasm/peptic pyloric stenosis it decreased significantly after therapy. Conclusion: Real time MRI is a reliable tool for assessment of gastric motion. Furthermore, differences in gastric motility index in patients with increased or decreased gastric motility could be evaluated and quantified. Due to the non-invasive character of MRI, this imaging modality may be an attractive alternative to conventional invasive diagnostic tools for gastric motility disorders and therapeutic monitoring.

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“…MRI has the potential to become an overall test to measure gastric emptying, volume change, and wall motion as a surrogate of contractile activity without radiation exposure (43,72,73,76,85,86,111). It also has the ability to separately assess the emptying of fat and water from the stomach (73).…”

Section: Other Technologies For Gastric Emptyingmentioning

confidence: 99%

Methods for measurement of gastric motility

Szarka¹,

Camilleri²

2009

American Journal of Physiology-Gastrointestinal and Liver Physi

103

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Szarka LA, Camilleri M. Methods for measurement of gastric motility. Am J Physiol Gastrointest Liver Physiol 296: G461-G475, 2009. First published January 15, 2009 doi:10.1152/ajpgi.90467.2008There is an array of tests available to measure gastric motility. Some tests measure end points, such as gastric emptying, that result from several different functions, whereas other tests are more specific and test only a single parameter, such as contractility. This article reviews the tests most commonly available in practice and research to evaluate in vivo the gastric functions of emptying, accommodation, contractility, and myoelectrical activity. The rationale for testing, the relative strengths and weaknesses of each test, and technical details are summarized. We also briefly indicate the applications and validations of the tests for use in experimental animal studies. contractility; emptying; accommodation; gastroparesis; dyspepsia ASSESSMENT OF THE MOTOR FUNCTIONS (motility) of the stomach is important in studies of gastric physiology and pathophysiology. Although not generally applied in gastroenterological practice, there is increasing use of tests to evaluate gastric function, particularly less invasive tests in clinical settings.There is an array of tests available to measure gastric motility. Some tests measure end points, such as gastric emptying, that result from several different functions, whereas other tests are more specific and test only a single parameter, such as contractility. This article reviews the tests most commonly available in practice and research to evaluate in vivo the gastric functions of emptying, accommodation, contractility, and myoelectrical activity. The rationale for testing, the relative strengths and weaknesses of each test, and technical details are summarized. A brief discussion is also provided for methods that have been used in animals to study motor functions of the stomach in animals. Tests to Evaluate Gastric Emptying of SolidsGastric emptying is a composite end point reflecting a variety of functions including gastric accommodation, the pressure gradient between the proximal and distal stomach, and antropyloroduodenal contractility and coordination. The trituration of solids and emptying of solid and liquid food from the stomach are arguably the most important physiological functions of the stomach. Abnormal gastric emptying, either accelerated at 1 h or delayed at 4 h, is among the factors that contribute to reporting of dyspepsia or the development of postprandial symptoms after meal challenge (35). For all tests of gastric motility and emptying, there are standard precautions (1): 1) Drugs affecting gastric motility (e.g., anticholinergics, narcotics, and prokinetics) are stopped for 48 h prior to the test, and the study is performed in the morning after an overnight fast. 2) Diabetic subjects should have a glucose level Ͻ275 mg/dl. 3) At the time the meal is ingested, Type 1 diabetic patients should receive half of their normal insulin dose. Gastric Emptying Scintigrap...

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Antral motility measurements by magnetic resonance imaging

Cited by 98 publications

References 17 publications

Modelling of the effects of Lotronex and Zelnorm on intestinal propulsion

Modelling of the effects of Lotronex and Zelnorm on intestinal propulsion

Real time high resolution magnetic resonance imaging for the assessment of gastric motility disorders

Methods for measurement of gastric motility

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