Antonio Richieri-Costa

Consolaro, Alberto; Martins-Ortiz, Maria Fernanda; Freitas, Patrícia; Consolaro, Renata Bianco; Castro, Carlos Henrique Bettoni Cruz de

doi:10.1590/s1415-54192004000200010

Cited by 1 publication

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“…On the root surface, cementoblasts do not have receptors for chemical mediators that promote bone remodeling or turnover such as those of systemic action, parathormone, calcitonin and estrogens; and local action, cytokines, growth factors and arachidonic acid products that act in bone areas associated with cellular stress and inflammation. 2 - 5 …”

Section: Bone Remodeling Is the Target Phenomenon Of Bisphosphonatesmentioning

confidence: 99%

“…During demineralization, the transport of bisphosphonate-bonded calcium via transcytosis carried out by means of clasts induce biochemical events capable of initiating apoptosis. 2 - 5 This process of natural death - in which cells die by structure fragmentation without causing flow of enzymes or molecules that induce inflammation - minimizes bone resorption and slows down the process of remodeling. Thus, bisphosphonates contribute to control bone remodeling or accelerated bone turnover, thereby preventing osteopenia and consequent osteoporosis.…”

Section: Bisphosphonates and Their Mechanisms Of Actionmentioning

confidence: 99%

“…Other mechanisms of action acting simultaneously or parallel to those of bisphosphonates have already been studied and proved. 2 - 5 , 7 , 8 , 10 - 14 The advent of bisphosphonates used to treat osteopenia and osteoporosis promoted an avalanche of publications, including extensive and thorough literature reviews. Every detail of this class of drugs has been properly explored on the book by Bijvoet et al 1 In the following paragraphs, we present a synthesis of potential mechanisms of action of bisphosphonates.…”

Section: Bisphosphonates and Their Mechanisms Of Actionmentioning

confidence: 99%

“…Scientific wisdom must be based on scientific evidence rather than opinion, word or faith. 2 - 5 , 10…”

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confidence: 99%

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The use of bisphosphonates does not contraindicate orthodontic and other types of treatment!

Consolaro

2014

Dental Press J. Orthod.

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Bisphosphonates have been increasingly used not only to treat bone diseases as well as conditions such as osteopenia and osteoporosis, but also in oncotherapy. The use of bisphosphonates induces clinicians to fear and care. These reactions are associated with controversy resulting from lack of in-depth knowledge on the mechanisms of action as well as lack of a more accurate assessment of side effects. Scientific and clinical knowledge disclosure greatly contributes to professionals' discernment and inner balance, especially orthodontists. Fear does not lead to awareness. For these reasons, we present an article that focuses on that matter. This article was adapted from different journals of different dental specialties, as mentioned on footnote. There is no scientific evidence demonstrating that bisphosphonates are directly involved with etiopathogenic mechanisms of osteonecrosis and jaw osteomyelitis. Their use is contraindicated and limited in cases of dental treatment involving bone tissue. Nevertheless, such fact is based on professional opinion, case reports, and personal experience or experiment trials with failing methods. Additional studies will always be necessary; however, in-depth knowledge on bone biology is of paramount importance to offer an opinion about the clinical use of bisphosphonates and their further implications. Based on bone biopathology, this article aims at contributing to lay the groundwork for this matter.

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Section: Bone Remodeling Is the Target Phenomenon Of Bisphosphonatesmentioning

confidence: 99%

Section: Bisphosphonates and Their Mechanisms Of Actionmentioning

confidence: 99%