Antler-derived microRNA PC-5p-1090 inhibits HCC cell proliferation, migration, and invasion by targeting MARCKS, SMARCAD1, and SOX9

MicroRNA PC-3p-2869 Regulates Antler Growth and Inhibits Proliferation and Migration of Human Osteosarcoma and Chondrosarcoma Cells by Targeting CDK8, EEF1A1, and NTN1

“…Antlers have been recognized as a valuable source for discovering bioactive agents for cancer therapy, with previous studies mainly focusing on antler polypeptides and extracts [20,21]. Our recent work [12] and the current study demonstrated the therapeutic…”

“…Antlers have been recognized as a valuable source for discovering bioactive agents for cancer therapy, with previous studies mainly focusing on antler polypeptides and extracts [ 20 , 21 ]. Our recent work [ 12 ] and the current study demonstrated the therapeutic potential of small nucleic acid molecules derived from antlers in cancer cells. Indeed, cross-species application of animal or plant miRNAs in human cancer has been widely reported [ 22 , 23 , 24 ].…”

“…MicroRNAs (miRNAs) are endogenous non-coding small RNA molecules approximately 19–24 nucleotides in length, which play critical regulatory roles in animals and plants by binding to complementary mRNAs for target cleavage or translational repression [ 10 ]. Insights into the roles of miRNAs in various physiological and pathological processes have made miRNAs attractive tools and targets for novel therapeutics [ 11 , 12 ]. Generally, a single miRNA simultaneously modulates numerous target genes, and in turn, the synergistic effects of target genes determine the biological function of miRNAs [ 13 ].…”