Antivirals against animal viruses

Villa, Tomás G.; Feijoo-Siota, Lucía; Rama, José Luis R.; Ageitos, José Manuel

doi:10.1016/j.bcp.2016.09.029

Cited by 46 publications

(45 citation statements)

References 276 publications

(307 reference statements)

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“…Lysozyme is a ubiquitous peptide that is widely distributed in animals, plants, bacteria and viruses ( 54 ). The antibacterial, immunomodulatory and antiviral functions of lysozyme are well-known in vertebrates ( 55 – 57 ). More than fifty lysozyme genes have been identified from several insects ( 58 ), but the antiviral activity of insect lysozymes has not been widely investigated.…”

Section: Insect Amps With Antiviral Activities: the Insect Avps In Pumentioning

confidence: 99%

Antimicrobial Peptides as Potential Antiviral Factors in Insect Antiviral Immune Response

et al. 2020

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Antimicrobial peptides (AMPs) with antiviral activity (antiviral peptides: AVPs) have become a research hotspot and already show immense potential to become pharmaceutically available antiviral drugs. AVPs have exhibited huge potential in inhibiting viruses by targeting various stages of their life cycle. Insects are the most speciose group of animals that inhabit almost all ecosystems and habitats on the land and are a rich source of natural AMPs. However, insect AVP mining, functional research, and drug development are still in their infancy. This review aims to summarize the currently validated insect AVPs, explore potential new insect AVPs and to discuss their possible mechanism of synthesis and action, with a view to providing clues to unravel the mechanisms of insect antiviral immunity and to develop insect AVP-derived antiviral drugs.

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Section: Insect Amps With Antiviral Activities: the Insect Avps In Pumentioning

confidence: 99%

Antimicrobial Peptides as Potential Antiviral Factors in Insect Antiviral Immune Response

et al. 2020

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“…(Asteraceae), and Zingiber officinale Roscoe (Zingiberaceae) [82]. Nevertheless, it is imperative to persevere with exploring and developing new antiviral compounds because viruses are continually evolving into new antiviral-resistant strains by virtue of their high mutation rate [1].…”

Section: Other Virusesmentioning

confidence: 99%

“…Viruses are unavoidable intracellular parasites that use the hostʼs cellular machinery to survive and multiply [1], often leading to serious diseases in both animals and humans. Antiviral drug resistance is an increasing concern in the immunocompromised patient population, where ongoing viral replication and prolonged drug exposure result in the emergence of resistant strains [2].…”

Section: Introductionmentioning

confidence: 99%

“…Prominent modes of action against viruses are inhibition of viral entry and its replication in the host cell via different mechanisms. Some of these plant compounds could inhibit cellular receptor kinases, thereby interfering with cellular signal transduction [1]. The challenges of drug treatment involve low efficiencies, cytotoxic effects, and development of viral resistance against them.…”

Section: Introductionmentioning

confidence: 99%

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Antiviral Medicinal Plants of Veterinary Importance: A Literature Review

Zitterl-Eglseer

Marschik

2020

Planta Med

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Viruses have a high mutation rate, and, thus, there is a continual emergence of new antiviral-resistant strains. Therefore, it becomes imperative to explore and develop new antiviral compounds continually. The search for pharmacological substances of plant origin that are effective against animal viruses, which have a high mortality rate or cause large economic losses, has garnered interest in the last few decades. This systematic review compiles 130 plant species that exhibit antiviral activity on 37 different virus species causing serious diseases in animals. The kind of extract, fraction, or compound exhibiting the antiviral activity and the design of the trial were particularly considered for review. The literature revealed details regarding plant species exhibiting antiviral activities against pathogenic animal virus species of the following families–Herpesviridae, Orthomyxoviridae, Paramyxoviridae, Parvoviridae, Poxviridae, Nimaviridae, Coronaviridae, Reoviridae, and Rhabdoviridae–that cause infections, among others, in poultry, cattle, pigs, horses, shrimps, and fish. Overall, 30 plant species exhibited activity against various influenza viruses, most of them causing avian influenza. Furthermore, 30 plant species were noted to be active against Newcastle disease virus. In addition, regarding the pathogens most frequently investigated, this review provides a compilation of 20 plant species active against bovine herpesvirus, 16 against fowlpox virus, 12 against white spot syndrome virus in marine shrimps, and 10 against suide herpesvirus. Nevertheless, some plant extracts, particularly their compounds, are promising candidates for the development of new antiviral remedies, which are urgently required.

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“…Antivirals are compounds which prevent viral development. Some of these antivirals can be isolated from sources, such as plants, animals, bacteria or fungi, while others can be obtained by chemical synthesis [ 13 , 14 ]. Antiviral mechanisms identified from natural products have shed light on how they interact with the viral life cycle, such as viral entry, replication, assembly, and release, as well as targeting of virus–host-specific interactions [ 5 , 6 ].…”

Section: Introductionmentioning

confidence: 99%

Antiviral Activities of Oleanolic Acid and Its Analogues

2018

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Viral diseases, such as human immune deficiency virus (HIV), influenza, hepatitis, and herpes, are the leading causes of human death in the world. The shortage of effective vaccines or therapeutics for the prevention and treatment of the numerous viral infections, and the great increase in the number of new drug-resistant viruses, indicate that there is a great need for the development of novel and potent antiviral drugs. Natural products are one of the most valuable sources for drug discovery. Most natural triterpenoids, such as oleanolic acid (OA), possess notable antiviral activity. Therefore, it is important to validate how plant isolates, such as OA and its analogues, can improve and produce potent drugs for the treatment of viral disease. This article reports a review of the analogues of oleanolic acid and their selected pathogenic antiviral activities, which include HIV, the influenza virus, hepatitis B and C viruses, and herpes viruses.

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Antivirals against animal viruses

Cited by 46 publications

References 276 publications

Antimicrobial Peptides as Potential Antiviral Factors in Insect Antiviral Immune Response

Antimicrobial Peptides as Potential Antiviral Factors in Insect Antiviral Immune Response

Antiviral Medicinal Plants of Veterinary Importance: A Literature Review

Antiviral Activities of Oleanolic Acid and Its Analogues

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