Antiviral zinc oxide nanoparticles mediated by hesperidin and in silico comparison study between antiviral phenolics as anti-SARS-CoV-2

Attia, Gouda H.; Moemen, Yasmine S.; Youns, Mаhmoud; Ibrahim, Ammar M.; Abdou, Randa; Raey, Mohamed A. El

doi:10.1016/j.colsurfb.2021.111724

Cited by 90 publications

(63 citation statements)

References 33 publications

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“…1 H NMR (400 MHz, DMSO- d 6 ), δ 6.93 (m, 3H, H-2′, H-5′ and H-6′), 6.15 (brs, 1H, H-6), 6.13 (brs, 1H, H-8), 5.50 (dd, J = 12.3, 3.3 Hz, 1H, H-2), 2.78 (dd, J = 3.2 Hz & 17.15, 1H, H-3 ax ), 3.25 (dd, J = 17.16, 8.21 Hz, 1H, H-3 eq ), 4.98 (d, J = 7.1 Hz, 1H, H-1″), 4.54 (s, 1H, H-1‴), 1.10 (d, J = 6.1, 3H, CH 3 of rhamnose). 13 C NMR (101 MHz, DMSO) δ 197.46 (C-4), 165.59 (C-7), 163.50 (C-5), 162.95 (C-9), 148.42 (C-3′), 146.90 (C-4′), 131.34 (C-1′), 118.44 (C-2′), 114.60 (C-6′), 112.48 (C-5′), 103.80 (C-10), 101.05 (C-1‴), 99.92 (C-1″), 96.87(C-6), 96.03 (C-8), 78.83 (C-2), 76.73 (C-3″), 75.99 (C-5″), 73.45 (C-2″), 72.55 (C-4‴), 71.19 (C-2‴), 70.74 (C-3‴), 70.07 (C-4″), 68.79 (C-5‴), 66.50 (C-6″), 56.15 (O-Me), 42.49 (C-3), 18.29 (C-6‴) [ 28 , 43 ].…”

Section: Resultsmentioning

confidence: 99%

Synergistic Effect of Mandarin Peels and Hesperidin with Sodium Nitrite against Some Food Pathogen Microbes

et al. 2021

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Food preservatives such as NaNO2, which are widely used in human food products, undoubtedly affect, to some extent, human organs and health. For this reason, there is a need to reduce the hazards of these chemical preservatives, by replacing them with safe natural bio-preservatives, or adding them to synthetic ones, which provides synergistic and additive effects. The Citrus genus provides a rich source of such bio-preservatives, in addition to the availability of the genus and the low price of citrus fruit crops. In this study, we identify the most abundant flavonoids in citrus fruits (hesperidin) from the polar extract of mandarin peels (agro-waste) by using spectroscopic techniques, as well as limonene from the non-polar portion using GC techniques. Then, we explore the synergistic and additive effects of hesperidin from total mandarin extract with widely used NaNO2 to create a chemical preservative in food products. The results are promising and show a significant synergistic and additive activity. The combination of mandarin peel extract with NaNO2 had synergistic antibacterial activity against B. cereus, Staph. aureus, E. coli, and P. aeruginosa, while hesperidin showed a synergistic effect against B. cereus and P. aeruginosa and an additive effect against Staph. aureus and E. coli. These results refer to the ability of reducing the concentration of NaNO2 and replacing it with a safe natural bio-preservative such as hesperidin from total mandarin extract. Moreover, this led to gaining benefits from their biological and nutritive values.

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Section: Resultsmentioning

confidence: 99%

Synergistic Effect of Mandarin Peels and Hesperidin with Sodium Nitrite against Some Food Pathogen Microbes

et al. 2021

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“…Zinc oxide nanoparticles are well absorbed and inexpensive. They are also low in toxicity and safe [100]. Zinc has an antiviral effect through a series of processes such as the effect on binding, penetration, infection, uncoating, and replication of the virus [101].…”

Section: Zinc Oxidementioning

confidence: 99%

Exploring the Role of Heavy Metals and Their Derivatives on the Pathophysiology of COVID-19

Bahrami

Arabestani

Taheri

et al. 2021

Biol Trace Elem Res

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Many aspects of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its disease, COVID-19, have been studied to determine its properties, transmission mechanisms, and pathology. These efforts are aimed at identifying potential approaches to control or treat the disease. Early treatment of novel SARS-CoV-2 infection to minimize symptom progression has minimal evidence; however, many researchers and firms are working on vaccines, and only a few vaccines exist. COVID-19 is affected by several heavy metals and their nanoparticles. We investigated the effects of heavy metals and heavy metal nanoparticles on SARS-CoV-2 and their roles in COVID-19 pathogenesis. AgNPs, AuNPs, gold-silver hybrid NPs, copper nanoparticles, zinc oxide, vanadium, gallium, bismuth, titanium, palladium, silver grafted graphene oxide, and some quantum dots were tested to see if they could minimize the severity or duration of symptoms in patients with SARS-CoV-2 infection when compared to standard therapy.

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“…This vital element is also involved in various enzyme processes such as metabolism and protein and nucleic acid biosynthesis. 15 …”

Section: Introductionmentioning

confidence: 99%

“…ZnONPs are characterized by their low toxicity and cost effectiveness and therefore can be applied in numerous therapeutic fields, such as wound healing and drug delivery, and for anticancer, antidiabetic, antibacterial and anti-inflammatory purposes. 15 …”

Section: Introductionmentioning

confidence: 99%

Antiviral Activity of Zinc Oxide Nanoparticles Mediated by Plumbago indica L. Extract Against Herpes Simplex Virus Type 1 (HSV-1)

Melk¹,

El‐Hawary²,

Melek³

et al. 2021

IJN

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Introduction Plumbago indica L. is considered a valuable source in the Plumbaginaceae family for various types of active compound such as alkaloids, phenolics and saponins. To promote the usage of P. indica in the bionanotechnology field, zinc oxide nanoparticles (ZnONPs) were biosynthesized by using its alcoholic extract. The inhibitory effects of ZnONPs and the plant extract were also evaluated against HSV-1. Methods ZnONPs were described by the following techniques, UV–visible spectroscopy, Fourier transform infrared spectroscopy (FTIR), dynamic light scattering (DLS), zeta potential, scanning electron microscopy (SEM), transmission electron microscopy (TEM) and x-ray diffraction (XRD). The phenolic and flavonoid contents of P. indica extract, which are accountable for bioreduction, formation and stabilization of the nanoparticles, were analyzed by HPLC technique. The antiviral assessment was implemented on both agents by using Vero cell lines. Results DLS revealed that the average size of ZnONPs was 32.58 ± 7.98 nm and the zeta potential was –20.8 mV. The observation of TEM analysis revealed that the particle size of ZnONPs varied from 2.56 to 8.83 nm. The XRD analysis verified the existence of pure crystals of hexagonal shapes of nanoparticles of ZnO with a main average size of 35.28 nm that is approximating to the values of particle size acquired by SEM analysis (19.64 and 23.21 nm). The HPLC analysis of P. indica ethanolic extract showed that gallic acid, chlorogenic acid and rutin were the major compounds, with concentrations equal to 8203.99, 2965.95 and 1144.99 µg/g, respectively. Regarding the antiviral assessment, the synthesized uncalcinated ZnONPs were found to exhibit a promising activity against HSV-1, with CC 50 and IC 50 values equal to 43.96 ± 1.39 and 23.17 ± 2.29 µg/mL, respectively. Conclusion The green synthesized ZnONPs are considered promising adjuvants to enhance the efficacy of HSV-1 drugs.

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Antiviral zinc oxide nanoparticles mediated by hesperidin and in silico comparison study between antiviral phenolics as anti-SARS-CoV-2

Abstract: Graphical abstract

Cited by 90 publications

References 33 publications

Synergistic Effect of Mandarin Peels and Hesperidin with Sodium Nitrite against Some Food Pathogen Microbes

Synergistic Effect of Mandarin Peels and Hesperidin with Sodium Nitrite against Some Food Pathogen Microbes

Exploring the Role of Heavy Metals and Their Derivatives on the Pathophysiology of COVID-19

Antiviral Activity of Zinc Oxide Nanoparticles Mediated by Plumbago indica L. Extract Against Herpes Simplex Virus Type 1 (HSV-1)

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