Antiviral Therapy

Gustafson, D. P.

doi:10.1016/s0195-5616(86)50136-4

Cited by 6 publications

(2 citation statements)

References 12 publications

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“…As first described by Witkowski et al in 1972, ribavirin (1-β-D-ribofuranosyl-1,2,4triazole-3-carboxamide) is a triazole nucleoside analogue that inhibits replication of both DNA and RNA viruses by interfering with viral mRNA synthesis (Witkowski et al 1973). It is active against a wide range of viruses including adenoviruses, arenaviruses, bunyaviruses, herpesviruses, orthomyxoviruses, paramyxoviruses, picornaviruses, poxviruses, retroviruses, rhabdoviruses and rotaviruses, but the strongest effect exhibits against influenza viruses and, in combination with interferon, against hepatitis C virus (Dolin 1985;Gustafson 1986;Te et al 2007). It has several possible mechanisms of action.…”

Section: Ribavirinmentioning

confidence: 99%

Antivirals: Past, Present and Future

Bule

Khan

Niaz

2019

Recent Advances in Animal Virology

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The uses of antiviral agents are increasing in the new era along with the development of vaccines for the effective control of viral diseases. The main aims of antiviral agents are to minimize harm to the host system and eradicate deadly viral diseases. However, the replications of viruses in host system represent a massive therapeutic challenge than bacteria and fungi. Antiviral drugs not just penetrate to disrupt the virus' cellular divisions but also have a negative impact on normal physiological pathways in the host. Due to these issues, antiviral agents have a narrow therapeutic index than antibacterial drugs. Nephrotoxicity is the main adverse reaction of antiviral drugs in human and animals. In this chapter, we summarize the antiviral agents' past, present and future perspectives with the main focus on the brief history of antiviral in animals, miscellaneous drugs, natural products, herbal and repurposing drugs.

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Section: Ribavirinmentioning

confidence: 99%

Antivirals: Past, Present and Future

Bule

Khan

Niaz

2019

Recent Advances in Animal Virology

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“…Clinical treatment is Antiviral chemistry in veterinary medicine: 1 257 non-specific, although FHV-1 associated keratitis may respond to local antiviral treatment with either Ara-A, 5-iodo-2'-deoxyuridine (IDU) or 5-trifluoromethyl-2'-deoxyurldine (Bistner et al, 1971;Roberts et aI., 1972;Bryan, 1980;Gaskell, 1984;Gustafson, 1986;Hoover, 1987). However, IDU administered l.p, at 50mg kg-1 to FRTV(feline rhinotracheitis virus, FHV-1) aerosol-infected cats had little effect on upper respiratory tract disease, there being eno reduction in pyrexia, nasal or ocular exudates, or sneezing (Steffenhagen et al, 1976).…”

Section: Feline Herpesvirusmentioning

confidence: 99%

Prospects for Antiviral Chemotherapy in Veterinary Medicine: 1. Feline Virus Diseases

Rollinson¹

1992

Antivir Chem Chemother

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This paper, which is published in two parts, reviews the literature pertaining to antiviral chemotherapy of viruses of veterinary importance. While early reports in the 1970s referred to the chemotherapy of a number of different RNA and DNA viruses, there was considerable focus in the 1980s, initially on herpesviruses and latterly on retroviruses, particularly in cats. Details are given of the successful treatments of FeLV and FIV, which have been used as animal models for HIV therapy. The high costs of developing and registering a new chemical entity, especially for food species, in which extensive toxicity/residue data are required, is the main reason why specific antiviral compounds are not currently available for veterinary use, although some non-specific immune modulators are now emerging. Concurrent availability of appropriate diagnostic tools is a prerequisite for successful veterinary antiviral chemotherapy, as is a greater understanding of the pathogenesis of virus infections in animals and the development of more sophisticated means of drug delivery, appropriate to both food animal species and companion animals. Additionally, antiviral agents are valuable as research tools per se, as opposed to solely as chemotherapeutic agents.

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The Influence of Host Factors on the Outcome of a Viral Infection

Ford

Greene

1986

Veterinary Clinics of North America: Small Animal Practice

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Antiviral Therapy

Cited by 6 publications

References 12 publications

Antivirals: Past, Present and Future

Antivirals: Past, Present and Future

Prospects for Antiviral Chemotherapy in Veterinary Medicine: 1. Feline Virus Diseases

The Influence of Host Factors on the Outcome of a Viral Infection

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