Antiviral therapies for influenza

Chan, Ken Kwok‐Keung; Hui, David

doi:10.1097/qco.0000000000000910

Cited by 9 publications

(1 citation statement)

References 95 publications

(135 reference statements)

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“…Tragically, influenza-related mortality rates vary between 290,000 and 650,000 deaths [ 3 ]. Furthermore, the clinical manifestations of influenza encompass a diverse array of symptoms, from acute upper respiratory tract infections to the development of severe pneumonia [ 4 ]. Conversely, some patients afflicted with severe influenza frequently exhibit respiratory dysfunction, as evidenced by reduced arterial pressure of oxygen to a fraction of the inspired oxygen ratio (≦ 200 mmHg).…”

Section: Introductionmentioning

confidence: 99%

Bioinformatics analysis identifies a key gene HLA_DPA1 in severe influenza-associated immune infiltration

Chen,

Hua,

2024

BMC Genomics

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Background Severe influenza is a serious global health issue that leads to prolonged hospitalization and mortality on a significant scale. The pathogenesis of this infectious disease is poorly understood. Therefore, this study aimed to identify the key genes associated with severe influenza patients necessitating invasive mechanical ventilation. Methods The current study utilized two publicly accessible gene expression profiles (GSE111368 and GSE21802) from the Gene Expression Omnibus database. The research focused on identifying the genes exhibiting differential expression between severe and non-severe influenza patients. We employed three machine learning algorithms, namely the Least Absolute Shrinkage and Selection Operator regression model, Random Forest, and Support Vector Machine-Recursive Feature Elimination, to detect potential key genes. The key gene was further selected based on the diagnostic performance of the target genes substantiated in the dataset GSE101702. A single-sample gene set enrichment analysis algorithm was applied to evaluate the participation of immune cell infiltration and their associations with key genes. Results A total of 44 differentially expressed genes were recognized; among them, we focused on 10 common genes, namely PCOLCE2, HLA_DPA1, LOC653061, TDRD9, MPO, HLA_DQA1, MAOA, S100P, RAP1GAP, and CA1. To ensure the robustness of our findings, we employed overlapping LASSO regression, Random Forest, and SVM-RFE algorithms. By utilizing these algorithms, we were able to pinpoint the aforementioned 10 genes as potential biomarkers for distinguishing between both cases of influenza (severe and non-severe). However, the gene HLA_DPA1 has been recognized as a crucial factor in the pathological condition of severe influenza. Notably, the validation dataset revealed that this gene exhibited the highest area under the receiver operating characteristic curve, with a value of 0.891. The use of single-sample gene set enrichment analysis has provided valuable insights into the immune responses of patients afflicted with severe influenza that have further revealed a categorical correlation between the expression of HLA_DPA1 and lymphocytes. Conclusion The findings indicated that the HLA_DPA1 gene may play a crucial role in the immune-pathological condition of severe influenza and could serve as a promising therapeutic target for patients infected with severe influenza.

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Section: Introductionmentioning

confidence: 99%