Abstract:NF-kB refers to a group of proteins involved in inflammatory, immune, and pro-and anti-apoptotic cellular responses. NF-kB mediated transactivation occurs through assembly of monomeric subunits at kB binding sites. In the classical pathway inhibitor of Kappa B (IkB) segregates NF-kB in the cytoplasm preventing entry to the nucleus. In response to a variety of stimuli, including cytokines and viral infection, IkB is phosphorylated by the IkB kinase complex (IKK) and degraded by the ubiquitin proteosome pathway,… Show more
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