Antiviral Substances with Systemic Effects Produced by Basidiomycetes such as<i>Fomes fomentarius</i>

Aoki, Michiko; Tan, Motomu; Fukushima, Atsushi; Hieda, Tadaharu; Kubo, Susumu; Takabayashi, Michiyo; Ono, Kuniaki; Mikami, Yoichi

doi:10.1271/bbb.57.278

Cited by 27 publications

(12 citation statements)

References 6 publications

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“…Previous studies demonstrated that the extracts of F. fomentarius possessed various biological activities. For example, Aoki et al [ 20 ] reported that polysaccharides from F. fomentarius inhibited the viral infection of tobacco, bell pepper, and tomato plants. In addition, the melanin-glucan complex isolated from F. fomentarius was also suggested to possess anti-infective activities against Helicobacter pylori , Candida albicans , Herpes vulgaris I, and human immunodeficiency virus 1 zmb in another study [ 21 ].…”

Section: Discussionmentioning

confidence: 99%

Differential Modulation of Lipopolysaccharide-Induced Inflammatory Cytokine Production by and Antioxidant Activity of Fomentariol in RAW264.7 Cells

Seo

Lee

et al. 2015

Mycobiology

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Medicinal mushrooms have been used worldwide to treat cancer and modulate the immune system. Over the last several years, there has been increasing interest in isolating bioactive compounds from medicinal mushrooms and evaluating their health beneficial effects. Fomes fomentarius is used in traditional oriental medicine and is known to possess antioxidant, anti-inflammatory, antidiabetic, and antitumor effects. In the present study, we isolated fomentariol from Fomes fomentarius and investigated its anti-inflammatory effect in murine macrophages (RAW264.7 cells) stimulated with lipopolysaccharides. Fomentariol inhibited the production of nitric oxide and intracellular reactive oxygen species triggered by lipopolysaccharides. Interestingly, fomentariol differentially regulated cytokine production triggered by lipopolysaccharides. Fomentariol effectively suppressed the production of interleukin-1β and interleukin-6 but not tumor necrosis factor-α. The inhibitory effect of fomentariol against nitric oxide, interleukin-1β, and interleukin-6 production was possibly mediated by downregulation of the extracellular signal-regulated kinase signaling pathway. Taken together, our results suggest that fomentariol differentially modulated inflammatory responses triggered by lipopolysaccharides in macrophages and is one of the bioactive compounds that mediate the physiological effects of Fomes fomentarius.

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Section: Discussionmentioning

confidence: 99%

Differential Modulation of Lipopolysaccharide-Induced Inflammatory Cytokine Production by and Antioxidant Activity of Fomentariol in RAW264.7 Cells

Seo

Lee

et al. 2015

Mycobiology

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“…Fungal polysaccharides with antiviral activity are summarized in Table 1. For example, BAS-F, a polysaccharide from Fomes fomentarius, at 2 µg•mL −1 can prevent tobacco mosaic virus (TMV) infection on the leaf surfaces (34). Porodaedalea pini (formerly known as Phellinus pini) produced two antiviral polysaccharides (EP-AV1 and EP-AV2) against HSV-1 and coxsackie virus B3 (CVB3) in Vero and HeLa cells, respectively.…”

Section: Antiviral Polysaccharides From Fungimentioning

confidence: 99%

“…Microbial polysaccharides and sulfated polysaccharides show various biological activities such as immunomodulatory, antioxidant, antimicrobial, anticancer, and anti-inflammatory activities (30). In particular, the antiviral activity of microbial polysaccharides has been studied, showing in several cases an inhibitory effect against various animal, human, and plant pathogenic viruses (33)(34)(35). Many studies have reported that natural and modified polysaccharides could inhibit various virus infections (36).…”

Section: Introductionmentioning

confidence: 99%

The Antiviral Activity of Bacterial, Fungal, and Algal Polysaccharides as Bioactive Ingredients: Potential Uses for Enhancing Immune Systems and Preventing Viruses

et al. 2021

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Viral infections may cause serious human diseases. For instance, the recent appearance of the novel virus, SARS-CoV-2, causing COVID-19, has spread globally and is a serious public health concern. The consumption of healthy, proper, functional, and nutrient-rich foods has an important role in enhancing an individual's immune system and preventing viral infections. Several polysaccharides from natural sources such as algae, bacteria, and fungi have been considered as generally recognized as safe (GRAS) by the US Food and Drug Administration. They are safe, low-toxicity, biodegradable, and have biological activities. In this review, the bioactive polysaccharides derived from various microorganisms, including bacteria, fungi, and algae were evaluated. Antiviral mechanisms of these polysaccharides were discussed. Finally, the potential use of microbial and algal polysaccharides as an antiviral and immune boosting strategy was addressed. The microbial polysaccharides exhibited several bioactivities, including antioxidant, anti-inflammatory, antimicrobial, antitumor, and immunomodulatory activities. Some microbes are able to produce sulfated polysaccharides, which are well-known to exert a board spectrum of biological activities, especially antiviral properties. Microbial polysaccharide can inhibit various viruses using different mechanisms. Furthermore, these microbial polysaccharides are also able to modulate immune responses to prevent and/or inhibit virus infections. There are many molecular factors influencing their bioactivities, e.g., functional groups, conformations, compositions, and molecular weight. At this stage of development, microbial polysaccharides will be used as adjuvants, nutrient supplements, and for drug delivery to prevent several virus infections, especially SARS-CoV-2 infection.

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“…Polysaccharides in F. fomentarius were also observed to have an inhibitory effect on the tobacco mosaic virus [46]. The in vitro antiviral activity of F. fomentarius against influenza virus A (H1N1) and herpes simplex virus (HSV-2) were investigated.…”

Section: Fomes Fomentariusmentioning

confidence: 99%

Medicinal properties of fungi occurring on Betula sp. trees. A review

Smolibowska

Szymański

2016

Herba Polonica

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S u m m a r yThe article presents the chemical costituents and pharmacological properties of polyporoid fungi found on birch, namely Piptoporus betulinus, Inonotus obliquus, Lenzites betulina, Fomes fomentarius, and Trametes versicolor. The in vitro and in vivo studies on the effect of different extracts from above-mentioned fungi on the human organism shown anti-cancer, anti-inflammatory, antiviral, antibacterial and immunostimulant activity, conditioned by the presence of such compounds as polysaccharides, polyphenols or terpenes. These fungi are commonly found in Poland and may superbly compete with Ganoderma lucidum (Reishi) or Lentinula edodes (Shitake) used in Asia for medicinal purposes.

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Antiviral Substances with Systemic Effects Produced by Basidiomycetes such asFomes fomentarius

Cited by 27 publications

References 6 publications

Differential Modulation of Lipopolysaccharide-Induced Inflammatory Cytokine Production by and Antioxidant Activity of Fomentariol in RAW264.7 Cells

Differential Modulation of Lipopolysaccharide-Induced Inflammatory Cytokine Production by and Antioxidant Activity of Fomentariol in RAW264.7 Cells

The Antiviral Activity of Bacterial, Fungal, and Algal Polysaccharides as Bioactive Ingredients: Potential Uses for Enhancing Immune Systems and Preventing Viruses

Medicinal properties of fungi occurring on Betula sp. trees. A review

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