Antiviral response in insects?

Kalmakoff, J.; Williams, Bryan R.G.; Austin, F. J.

doi:10.1016/0022-2011(77)90170-7

Cited by 8 publications

(1 citation statement)

References 17 publications

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“…Since cultured mosquito or tick cells are not known to release interferon like substance [16,17] nor defective dengue virus particles [3], the characterization of such an interfering substance or particle in the in fected A.albopictus cell cultures is important. In this study, dengue virus replication was slightly reduced in the cultures previously treated with virus-free supernatants from PI cultures.…”

Section: Discussionmentioning

confidence: 99%

Persistent Infection of a Nonvector Mosquito Cell Line (TRA-171) with Dengue Viruses

Kuno

1982

Intervirology

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Dengue viruses often caused an apparent, persistent infection in a cell line derived from a nonvector mosquito, Toxorhynchites amboinensis. The characteristics of the viruses were modified during the course of persistent infection, as demonstrated by the changes in neutralizing titers of hyperimmune ascitic fluids against dengue serotypes, increased ability to induce syncytia, and increased temperature sensitivity. Although neurovirulence in suckling mice was reduced for all serotypes, considerable levels of neurovirulence were detected for DEN-1, DEN-2, and DEN-4, after 1 year in culture. Replication of the original viruses was not significantly inhibited when the cell cultures were treated with virus-free supernatant fluids from persistently infected cultures.

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Section: Discussionmentioning

confidence: 99%