Antiviral Protein of<i>Momordica charantia</i>L. Inhibits Different Subtypes of Influenza A

Pongthanapisith, Viroj; Ikuta, Kazuyoshi; Puthavathana, Pilaipan; Leelamanit, Wichet

doi:10.1155/2013/729081

Cited by 34 publications

(18 citation statements)

References 23 publications

(18 reference statements)

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“…Particularly, hairy roots and non-transgenic roots (1 mg/mL) showed virus yield reduced (42 and 58%) respectively after 24 h incubation. Previously, M. charantia was reported to possess several antivi-ral activities including hepatitis B virus, dengue virus, and human immunodeficiency virus (HIV) and influenza A subtypes including H1N1, H3N2, H5N1 (Pongthanapisith et al, 2013). Consistent with our reports hairy roots have potential antiviral activity compared with non-transgenic roots in Phylanthus amarus (Bhattacharyya and Bhattacharya, 2004) and Daucus carota (Luchakivskaya et al, 2012).…”

Section: Comparison Of Antimicrobial (Antibacterial Antifungal and Asupporting

confidence: 90%

Induction of hairy roots by Agrobacterium rhizogenes -mediated transformation of spine gourd ( Momordica dioica Roxb. ex. willd) for the assessment of phenolic compounds and biological activities

Thiruvengadam

Rekha

Chung

2016

Scientia Horticulturae

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a b s t r a c tAn efficient protocol for hairy root induction of spine gourd (Momordica dioica) was established using Agrobacterium rhizogenes (KCTC 2703). This study evaluates the phenolic compound production, antioxidant and antimicrobial (antibacterial, antifungal and antiviral) activities of transgenic hairy root cultures in M. dioica . Hairy roots were induced from leaves, petiole, and internodal explants. Molecular analysis of PCR and gene sequencing using specific primers of rolC and aux1 revealed T-DNA integration in the hairy root clones and RT-PCR analysis confirmed the expression of hairy root inducible genes (rolC and aux1). The greatest biomass accumulation of hairy roots on MS liquid medium supplemented with 3% sucrose was observed at 22 days. Ultra-HPLC was used to compare the individual phenolic compound contents of transgenic and non-transgenic roots. Moreover, transgenic hairy roots efficiently produced several phenolic compounds, such as flavonols, hydroxycinnamic acid and hydroxybenzoic acid derivatives. The total phenolic, flavonoid contents and biological (antioxidant, antibacterial, antifungal and antiviral) activities were higher in hairy roots compared to non-transformed roots. These results demonstrate the greater potentiality of M. dioica hairy root cultures for the production of valuable phenolic compounds and for studies of their biological activity.

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Section: Comparison Of Antimicrobial (Antibacterial Antifungal and Asupporting

confidence: 90%

Induction of hairy roots by Agrobacterium rhizogenes -mediated transformation of spine gourd ( Momordica dioica Roxb. ex. willd) for the assessment of phenolic compounds and biological activities

Thiruvengadam

Rekha

Chung

2016

Scientia Horticulturae

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“…Various extracts of MC are studied for biological activities, including anti-oxidant [15] , anti-diabetic [16] , anti-cancer [17] , anti-inflammatory [18] , anti-bacterial [19] , antifungal [20] , anti-viral [21] , anti-HIV [22] , anti-helminthic [23] , anti-mycobac-terial [24] , hypotensive [25] , anti-obesity [26] , immunomodulatory [27] , anti-hyperlipidemic [28] , hepatoprotective [29] , and neuropro-tective [30] activities. Several chemical constituents such as cucurbitane type triterpenoids, cucurbitane type glycosides, triterpene saponins, phenolic, and flavonoid compounds, and some protein fractions have been isolated from MC [31] .…”

Section: Introductionmentioning

confidence: 99%

Bitter melon: a panacea for inflammation and cancer

Dandawate

Subramaniam

Padhyé³

et al. 2016

Chinese Journal of Natural Medicines

114

123

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Nature is a rich source of medicinal plants and their products that are useful for treatment of various diseases and disorders. Momordica charantia, commonly known as bitter melon or bitter gourd, is one of such plants known for its biological activities used in traditional system of medicines. This plant is cultivated in all over the world, including tropical areas of Asia, Amazon, east Africa, and the Caribbean and used as a vegetable as well as folk medicine. All parts of the plant, including the fruit, are commonly consumed and cooked with different vegetables, stir-fried, stuffed or used in small quantities in soups or beans to give a slightly bitter flavor and taste. The plant is reported to possess anti-oxidant, anti-inflammatory, anti-cancer, anti-diabetic, anti-bacterial, anti-obesity, and immunomodulatory activities. The plant extract inhibits cancer cell growth by inducing apoptosis, cell cycle arrest, autophagy and inhibiting cancer stem cells. The plant is rich in bioactive chemical constituents like cucurbitane type triterpenoids, triterpene glycosides, phenolic acids, flavonoids, essential oils, saponins, fatty acids, and proteins. Some of the isolated compounds (Kuguacin J, Karaviloside XI, Kuguaglycoside C, Momordicoside Q–U, Charantin, α-eleostearic acid) and proteins (α-Momorcharin, RNase MC2, MAP30) possess potent biological activity. In the present review, we are summarizing the anti-oxidant, anti-inflammatory, and anti-cancer activities of Momordica charantia along with a short account of important chemical constituents, providing a basis for establishing detail biological activities of the plant and developing novel drug molecules based on the active chemical constituents.

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“…Momordica charantia [18] 500 mg/day Powder of Momordica charantia extract filled in a capsule at 06.00 Hrs with one cup of warm water before breakfast…”

Section: Phytomedicine Scientific Names Quantity Given Mode and Time mentioning

confidence: 99%

Treatment and Control of Covid-19 (Corona Virus Disease 2019) By Non-invasive (h.i.p) Non-drug Therapy in Combination Anti-influenza an (Oseltamivir (rx) Tamiflue) Drug-Novel Case Report

Ather¹,

Costigliola²

2020

SSR-IIJLS

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Background:Covid-19 is a new born sibling of the influenza family of SARS-CoV-2, named on February 11, as a new type of corona virus by the WHO. Covid-19 indicates its close relationship with activity and approaches with the SARS virus, which further triggered as epidemic in 2003 and 2004 and now similar lung triggered by SARS-CoV-2 is called Covid-19 (Corona Virus Disease 2019). Methods: A combination of integrative therapies were administered to a 27 year old female positive with unknown SARS-CoV identified as COVID-19 with a query of coronavirus contaminated from travel history and a student of Wuhan with a respiratory congestion, integrative approach of non-invasive (ion therapy) and non-drug therapy, quantitative analysis by real time PCR, vital signs were recorded beforeand after the treatment, as all the vitals were normal and real time PCR results were monitored. Results: The integrative therapy with isolation for 29 days from 31 st January to 27 th February was found to be satisfactory and the report, which has Real time PCR values detecting Covid-19 positive on 29 th January 2020 gave a negative result,it showed not detected and less than 35 Ct for the test. Conclusion: The integrative approach showed that it has high potential in treatment of Covid-19and can further imbibed in republic of china as well as other places where in 136 volunteers are part of the study and this could be an adjuvant therapy with a integrative approach for Covid-19 treatments.

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Antiviral Protein ofMomordica charantiaL. Inhibits Different Subtypes of Influenza A

Cited by 34 publications

References 23 publications

Induction of hairy roots by Agrobacterium rhizogenes -mediated transformation of spine gourd ( Momordica dioica Roxb. ex. willd) for the assessment of phenolic compounds and biological activities

Induction of hairy roots by Agrobacterium rhizogenes -mediated transformation of spine gourd ( Momordica dioica Roxb. ex. willd) for the assessment of phenolic compounds and biological activities

Bitter melon: a panacea for inflammation and cancer

Treatment and Control of Covid-19 (Corona Virus Disease 2019) By Non-invasive (h.i.p) Non-drug Therapy in Combination Anti-influenza an (Oseltamivir (rx) Tamiflue) Drug-Novel Case Report

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