Antiviral properties of the seed extract of an Indian medicinal plant, Pongamia pinnata, Linn., against herpes simplex viruses: In-vitro studies on Vero cells

Elanchezhiyan, M; Rajarajan, S; Rajendran, P.; Subramanian, S.; Thyagarajan, Sadras Panchatcharam

doi:10.1099/00222615-38-4-262

Cited by 43 publications

(14 citation statements)

References 2 publications

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“…For example, Brijesh et al [13] were able to demonstrate that while a leaf decoction did not have biocidal activity against Giardia lamblia, rotavirus, or strains of Escherichia coli, Vibrio cholerae or Shigella flexneri, it significantly reduced the production of cholera toxin by V. cholerae and the invasion of HEp-2 cells by E. coli. In contrast, a crude seed extract of P. pinnata was able to completely inhibit the growth of herpes simplex virus type 1 and type 2 in Vero cells [21]. Bark, leaf, and to a lesser extent, seed extracts, inhibited the activity of the malaria parasite Plasmodium falciparum in an in vitro assay using parasitized erythrocytes [68].…”

Section: Biomedical and Biocidal Propertiesmentioning

confidence: 94%

Pongamia pinnata: An Untapped Resource for the Biofuels Industry of the Future

et al. 2008

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Pongamia pinnata (L.) Pierre is a fast-growing leguminous tree with the potential for high oil seed production and the added benefit of the ability to grow on marginal land. These properties support the suitability of this plant for large-scale vegetable oil production required by a sustainable biodiesel industry. The future success of P. pinnata as a sustainable source of feedstock for the biofuels industry is dependent on an extensive knowledge of the genetics, physiology and propagation of this legume. In particular, research should be targeted to maximizing plant growth as it relates to oil biosynthesis. This review assesses and integrates the biological, chemical and genetic attributes of the plant, providing the basis for future research into Pongamia's role in an emerging industry.

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Section: Biomedical and Biocidal Propertiesmentioning

confidence: 94%

Pongamia pinnata: An Untapped Resource for the Biofuels Industry of the Future

et al. 2008

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“…There is a debate as to its probable origin outside India although conclusive evidence to it is yet to be provided. The tree has numerous medicinal uses ranging from time tested folk medicine for human and animal aliments like; abdominal tumours skin ailments, liniment for rheumatism, colds, coughs, diarrhoea, dyspepsia, flatulence, gonorrhoea and leprosy to clinically tested antiseptic, antimicrobial, antiviral and antihyperglycemic activity (Rameshthangam and Ramasamy 2007;Punitha and Manoharan 2006;Elanchezhiyan et al 1993). The seeds contain pongam oil, bitter, red brown, thick, non-drying, non-edible oil, which is used for tanning leather, soap, as a liniment to treat scabies, herpes, and rheumatism and as an illuminating oil (Burkill 1966).…”

Section: Introductionmentioning

confidence: 99%

Diversity and variability in seed characters and growth of Pongamia pinnata (L.) Pierre accessions

Rao

Shanker

Srinivas

et al. 2011

Trees

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A thorough and extensive wild germplasm exploration survey was undertaken and 50 high yielding candidate plus trees (CPTs) of Pongamia pinnata (L.) Pierre from different locations from a latitudinal and longitudinal spread between 12°41 0 and 22°E longitude and 77°and 84°40 0 N latitude covering 11 locations in an area spread of 150,000 km 2 were collected for evaluating genetic association and variability in seed and growth characters. There were significant differences observed in seed morphology and oil content as was in plant height, and number of branches in the progeny trial. Plant height and number of branches exhibited much higher values of both phenotypic and genotypic variance than observed in the seed characters. Among seed characters oil content exhibited highest broad sense heritability of more than 93% followed by seed length (90.0%). In contrast seed width showed the second highest genetic advance of 5.64% following the highest genetic advance of 10.15% exhibited by oil content. Hierarchical clustering by Ward's Minimum Variance Cluster Analysis method showed phylogeographic patterns of genetic diversity. K means clustering revealed that trees from different geographic regions were grouped together in a cluster and as were trees from the same geographical area placed in different clusters suggesting that geographical diversity did not go hand in hand with genetic diversity. In addition clustering identified promising accessions with favourable traits for future establishment of orchards.

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“…However, clinical evaluation was not done. [29] Phyllanthus niruri, which was previously shown to have activity against hepatitis B virus, was shown to have an inhibitory effect against HIV-1. The activity was in an alkaloidal extract of P. niruri.…”

Section: Anti-bacterial Effects Including Anti-tuberculous Activity Omentioning

confidence: 99%

Could the products of Indian medicinal plants be the next alternative for the treatment of infections?

Nandagopal

Sankar

Ramamurthy

et al. 2011

Indian Journal of Medical Microbiology

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Indian medicinal plants are now recognized to have great potential for preparing clinically useful drugs that could even be used by allopathic physicians. Traditionally, practitioners of Indian medicine have used plant products in powder, syrup or lotion forms, without identification, quantification and dose regulation, unlike their allopathic counterparts. The present review explores the immense potential of the demonstrated effect of Indian medicinal plants on microbes, viruses and parasites. In the present context, with the available talent in the country like pharmaceutical chemists, microbiologists, biotechnologists and interested allopathic physicians, significant national effort towards identification of an "active principle" of Indian medicinal plants to treat human and animal infections should be a priority.

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Antiviral properties of the seed extract of an Indian medicinal plant, Pongamia pinnata, Linn., against herpes simplex viruses: In-vitro studies on Vero cells

Cited by 43 publications

References 2 publications

Pongamia pinnata: An Untapped Resource for the Biofuels Industry of the Future

Pongamia pinnata: An Untapped Resource for the Biofuels Industry of the Future

Diversity and variability in seed characters and growth of Pongamia pinnata (L.) Pierre accessions

Could the products of Indian medicinal plants be the next alternative for the treatment of infections?

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