Antiviral properties of resveratrol against pseudorabies virus are associated with the inhibition of IκB kinase activation

Zhao, Xinghong; Cui, Qiankun; Fu, Qiuting; Song, Xu; Jia, Renyong; Yang, Yi; Zou, Yuanfeng; Li, Lixia; He, Chao; Liang, Xiaoxia; Yin, Lizi; Lin, Johnson; Ye, Gang; Shu, Gang; Zhao, Ling; Shi, Fei; Lü, Cheng

doi:10.1038/s41598-017-09365-0

Cited by 59 publications

(59 citation statements)

References 40 publications

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“…HO-1-derived CO was also indicated to play a key role in the antiviral activity of HO-1, whereby CO scavenger Hb partially reversed the inhibitory effect of CoPP-induced HO-1 on PRV replication. Previous studies have demonstrated that CO decreases the replication ability of PRRSV by suppressing the activation of the NF-κB signaling pathway, which plays a significant role in PRV replication Zhao et al, 2017). Thus, the NF-κB signaling pathway may act as a potential target for the HO-1/CO system to exert its antiviral effect.…”

Section: Discussionmentioning

confidence: 98%

The Cytoprotective Enzyme Heme Oxygenase-1 Suppresses Pseudorabies Virus Replication in vitro

et al. 2020

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Pseudorabies virus (PRV) infection brings about great economic losses to the swine industry worldwide, as there are currently no effective therapeutic agents or vaccines against this disease, and mutations in endemic wild virulent PRV strains result in immune failure of traditional vaccines. Heme oxygenase-1 (HO-1) catalyzes the conversion of heme into biliverdin (BV), iron and carbon monoxide (CO), all of which have been demonstrated to protect cells from various stressors. However, the role of HO-1 in PRV replication remains unknown. Thus, the present study aimed to investigate the effect of HO-1 on PRV replication and determine its underlying molecular mechanisms. The results demonstrated that induction of HO-1 via cobalt-protoporphyrin (CoPP) markedly suppressed PRV replication, while HO-1 specific small interfering RNA or inhibitor zinc-protoporphyrin partially reversed the inhibitory effect of CoPP on PRV replication. Furthermore, overexpression of HO-1 notably inhibited PRV replication, while knockdown of endogenous HO-1 expression promoted PRV replication. Mechanism analyses indicated that the HO-1 downstream metabolites, CO and BV/BR partially mediated the virus suppressive effect of HO-1. Taken together, the results of the present study suggest that HO-1 may be developed as a novel endogenous antiviral factor against PRV, and the HO-1/BV/CO system may constitute a unique antiviral protection network during PRV infection and interaction with host cells.

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Section: Discussionmentioning

confidence: 98%

The Cytoprotective Enzyme Heme Oxygenase-1 Suppresses Pseudorabies Virus Replication in vitro

et al. 2020

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“…Some dietary polyphenols (e.g., quercetin, resveratrol, rutin) show a certain efficacy against leishmaniosis [90], and giardiasis [91]; furthermore, resveratrol itself has been suggested as a potential restorative agent against toxoplasmosis brain disorders [92] and Schistosoma mansoni infections [93]. As far as the effects on viruses, human and animal evidence suggest polyphenolic compounds (e.g., resveratrol, tea polyphenols) possess potential preventive and therapeutic effects, and might be used as adjuvant therapy for the management of viral infection, e.g., influenza, herpes simplex, pseudorabies, hepatitis C, porcine reproductive and respiratory syndrome, and even Ebola [88,[94][95][96][97].…”

Section: Discussionmentioning

confidence: 99%

Nutrigenomic Effects of Long-Term Grape Pomace Supplementation in Dairy Cows

Pauletto

Elgendy

Ianni

et al. 2020

Animals

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The increasing demand for more animal products put pressure on improving livestock production efficiency and sustainability. In this context, advanced animal nutrition studies appear indispensable. Here, the effect of grape pomace (GP), the polyphenol-rich agricultural by-product, was evaluated on Holstein-Friesian cows’ whole-blood transcriptome, milk production and composition. Two experimental groups were set up. The first one received a basal diet and served as a control, while the second one received a 7.5% GP-supplemented diet for a total of 60 days. Milk production and composition were not different between the group; however, the transcriptome analysis revealed a total of 40 genes significantly affected by GP supplementation. Among the most interesting down-regulated genes, we found the DnaJ heat-shock protein family member A1 (DNAJA1), the mitochondrial fission factor (MFF), and the impact RWD domain protein (IMPACT) genes. The gene set enrichment analysis evidenced the positive enrichment of ‘interferon alpha (IFN-α) and IFN-γ response’, ‘IL6-JAK-STAT3 signaling’ and ‘complement’ genes. Moreover, the functional analysis denoted positive enrichment of the ‘response to protozoan’ and ‘negative regulation of viral genome replication’ biological processes. Our data provide an overall view of the blood transcriptomic signature after a 60-day GP supplementation in dairy cows which mainly reflects a GP-induced immunomodulatory effect.

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“…Firstly, overactivation of the NF-κB and MAPKs pathways were observed in LPS-induced inflammation (7,21). NF-κB, a critical regulator of cytokine production, cell activation and proliferation, serves an important role in regulating inflammation and immune responses to extracellular stimulus (22).…”

Section: Discussionmentioning

confidence: 99%

Resveratrol inhibits LPS‑induced inflammation through suppressing the signaling cascades of TLR4‑NF‑κB/MAPKs/IRF3

Chen

Song

et al. 2019

Exp Ther Med

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Resveratrol (Res) is a natural compound that possesses anti-inflammatory properties. However, the protective molecular mechanisms of Res against lipopolysaccharide (LPS)-induced inflammation have not been fully studied. In the present study, RAW264.7 cells were stimulated with LPS in the presence or absence of Res, and the subsequent modifications to the LPS-induced signaling pathways caused by Res treatment were examined. It was identified that Res decreased the mRNA levels of Toll-like receptor 4 (TLR4), myeloid differentiation primary response protein MyD88, TIR domain-containing adapter molecule 2, which suggested that Res may inhibit the activation of the TLR4 signaling pathway. It suppressed the expression levels of total and phosphorylated TLR4, NF-κB inhibitor, p38 mitogen-activated protein kinase (MAPK), c-Jun N-terminal kinase, extracellular signal-regulated kinase 1/2 and interferon (IFN) regulatory factor 3 (IRF3) proteins. Following treatment with Res or specific inhibitors, the production of pro-inflammatory mediators including tumor necrosis factor-α, interleukin (IL)-6, IL-8 and IFN-β were decreased and the expression of anti-inflammatory mediator IL-10 was increased. These results suggested that Res may inhibit the signaling cascades of NF-κB, MAPKs and IRF3, which modulate pro-inflammatory cytokines. In conclusion, Res exhibited a therapeutic effect on LPS-induced inflammation through suppression of the TLR4-NF-κB/MAPKs/IRF3 signaling cascades.

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Antiviral properties of resveratrol against pseudorabies virus are associated with the inhibition of IκB kinase activation

Cited by 59 publications

References 40 publications

The Cytoprotective Enzyme Heme Oxygenase-1 Suppresses Pseudorabies Virus Replication in vitro

The Cytoprotective Enzyme Heme Oxygenase-1 Suppresses Pseudorabies Virus Replication in vitro

Nutrigenomic Effects of Long-Term Grape Pomace Supplementation in Dairy Cows

Resveratrol inhibits LPS‑induced inflammation through suppressing the signaling cascades of TLR4‑NF‑κB/MAPKs/IRF3

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