Antiviral properties of isoborneol, a potent inhibitor of herpes simplex virus type 1

Armaka, Marietta; Papanikolaou, Eleni; Sivropoulou, Afroditi; Arsenakis, Minas

doi:10.1016/s0166-3542(99)00036-4

Cited by 132 publications

(71 citation statements)

References 30 publications

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“…In particular, the antiviral properties of essential oils from several plant extracts, responsible for their characteristic odor, have been described in recent years (Hayashi et al, 1995;Armaka et al, 1999;Benencia and Courreges, 1999;De Logu et al, 2000;Baqui et al, 2001;Primo et al, 2001;Schnitzler et al, 2001). Various herpesviruses, including the human pathogens herpes simplex virus type 1 (HSV-1) and 2 (HSV-2), were found to be very susceptible to the inhibitory action of this type of natural products.…”

Section: Introductionmentioning

confidence: 99%

Virucidal activity of essential oils from aromatic plants of San Luis, Argentina

Garcı́a

Talarico

Almeida

et al. 2003

Phytotherapy Research

112

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Essential oils obtained from eight aromatic plants of San Luis Province, Argentina, were screened for virucidal activity against herpes simplex virus type 1 (HSV-1), Junin virus (JUNV) and dengue virus type 2 (DEN-2). The most potent inhibition was observed with the essential oil of Lippia junelliana and Lippia turbinata against JUNV with virucidal concentration 50% (VC(50)) values in the range 14-20 ppm, whereas Aloysia gratissima, Heterotheca latifolia and Tessaria absinthioides inhibited JUNV in the range 52-90 ppm. The virucidal activity was time- and temperature-dependent. The essential oils of A. gratissima, Artemisia douglasiana, Eupatorium patens and T. absinthioides inactivated HSV-1 at 65-125 ppm. However, only A. douglasiana and E. patens had any discernible effect on DEN-2 infectivity with VC(50) values of 60 and 150 ppm, respectively.

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Section: Introductionmentioning

confidence: 99%

Virucidal activity of essential oils from aromatic plants of San Luis, Argentina

Garcı́a

Talarico

Almeida

et al. 2003

Phytotherapy Research

112

View full text Add to dashboard Cite

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“…An interesting activity with an IC 50 value of 60 mg/ml was found when L. nobilis berry oil was incubated with HSV-1 virus. Armaka et al reported the ability of isoborneol to completely inhibit HSV-1 replication, without affecting viral adsorption [11]. The content of this monoterpene in L. nobilis berry oil was found in low percentage, and probably, therefore, it is not able to exert antiviral activity against HSV-1.…”

mentioning

confidence: 99%

Phytochemical Analysis and in vitro Antiviral Activities of the Essential Oils of Seven Lebanon Species

Loizzo

Saab

Tundis

et al. 2008

Chemistry & Biodiversity

234

170

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The chemical composition of the essential oils of Laurus nobilis, Juniperus oxycedrus ssp. oxycedrus, Thuja orientalis, Cupressus sempervirens ssp. pyramidalis, Pistacia palaestina, Salvia officinalis, and Satureja thymbra was determined by GC/MS analysis. Essential oils have been evaluated for their inhibitory activity against SARS-CoV and HSV-1 replication in vitro by visually scoring of the virus-induced cytopathogenic effect post-infection. L. nobilis oil exerted an interesting activity against SARS-CoV with an IC(50) value of 120 microg/ml and a selectivity index (SI) of 4.16. This oil was characterized by the presence of beta-ocimene, 1,8-cineole, alpha-pinene, and beta-pinene as the main constituents. J. oxycedrus ssp. oxycedrus oil, in which alpha-pinene and beta-myrcene were the major constituents, revealed antiviral activity against HSV-1 with an IC(50) value of 200 microg/ml and a SI of 5.

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“…In the presence of isoborneol, the glycosylation of certain viral polypeptides was inhibited, while the glycosylation of cellular proteins remained unchanged. When copies of these viral proteins were introduced into the cellular genome and expressed there, glycosylation was normal in the presence of isoborneol (40). This finding seems to indicate that isoborneol is a promising new candidate for HSV treatment.…”

Section: Natural Products With Anti-herpes Simplex Virus Activitymentioning

confidence: 85%

Herpes simplex virus: Drug resistance and new treatment options using natural products (Review)

Mundinger

Efferth²

2008

Mol Med Rep

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Abstract. As herpes simplex infections are very common worldwide, new treatment options are of high importance, especially for immunosuppressed individuals. Although the standard treatment options have shown high effectiveness for decades, the risk that drug resistance will emerge remains significant. It is therefore important that new drug targets and new treatments are investigated, not just in preliminary tests, but also in vitro, in vivo and by clinical testing. One valuable source for new treatments is the abundance of molecules from natural products that have been shown to possess antiviral properties. Several potential candidates for the development of new anti-herpes drugs are discussed in this short review. Contents1. Standard treatment of herpes simplex virus infections 2. Natural products with anti-herpes simplex virus activity 3. Conclusions

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Antiviral properties of isoborneol, a potent inhibitor of herpes simplex virus type 1

Cited by 132 publications

References 30 publications

Virucidal activity of essential oils from aromatic plants of San Luis, Argentina

Virucidal activity of essential oils from aromatic plants of San Luis, Argentina

Phytochemical Analysis and in vitro Antiviral Activities of the Essential Oils of Seven Lebanon Species

Herpes simplex virus: Drug resistance and new treatment options using natural products (Review)

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