Antiviral Potency of Mushroom Constituents

Pradeep, Prabin; Manju, Vidya; Ahsan, Mohammad Feraz

doi:10.1007/978-981-13-6382-5_10

Cited by 11 publications

(12 citation statements)

References 99 publications

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“…This observation may suggest the release of substance(s) from the mushroom that contributed to this initial reduction in infectious virus. Previous reports using cell culture have shown that extracts from various mushroom types have some level of antiviral activity against HIV, influenza A and B, HSV-1 and HSV-2, and hepatitis B and C viruses [ 54 ]. This antiviral activity may be due in part to ganodermadiol, a sterol in mushrooms, which has been shown to be effective against HSV-1 [ 55 ].…”

Section: Discussionmentioning

confidence: 99%

Survival of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) and Herpes Simplex Virus 1 (HSV-1) on Foods Stored at Refrigerated Temperature

Dhakal

Jia

Joyce

et al. 2021

Foods

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Outbreaks of coronavirus infectious disease 2019 (COVID-19) in meat processing plants and media reports of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) detection on foods have raised concerns of a public health risk from contaminated foods. We used herpes simplex virus 1, a non-Biosafety Level 3 (non-BSL3) enveloped virus, as a surrogate to develop and validate methods before assessing the survival of infectious SARS-CoV-2 on foods. Several food types, including chicken, seafood, and produce, were held at 4 °C and assessed for infectious virus survival (herpes simplex virus 1 (HSV-1) and SARS-CoV-2) at 0 h, 1 h, and 24 h post-inoculation (hpi) by plaque assay. At all three time points, recovery of SARS-CoV-2 was similar from chicken, salmon, shrimp, and spinach, ranging from 3.4 to 4.3 log PFU/mL. However, initial (0 h) virus recovery from apples and mushrooms was significantly lower than that from poultry and seafood, and infectious virus decreased over time, with recovery from mushrooms becoming undetectable by 24 hpi. Comparing infectious virus titers with viral genome copies confirmed that PCR-based tests only indicate presence of viral nucleic acid, which does not necessarily correlate with the quantity of infectious virus. The survival and high recovery of SARS-CoV-2 on certain foods highlight the importance of safe food handling practices in mitigating any public health concerns related to potentially contaminated foods.

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Section: Discussionmentioning

confidence: 99%

Survival of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) and Herpes Simplex Virus 1 (HSV-1) on Foods Stored at Refrigerated Temperature

Dhakal

Jia

Joyce

et al. 2021

Foods

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“…In another study, peptides produced by the marine-derived fungus Scytalidium were found to have antiviral activity against HSV-1 and HSV-2, particularly by a peptide named Halovir, which was suggested to have virucidal activity when in direct contact with HSV-1 and HSV-2 (Figure 1) (Rowley et al, 2003). Furthermore, an aqueous extract from Inonotus obliquus (AEIO) was shown to inhibit HSV-1 infection in Vero cells (Pradeep et al, 2019). the antiviral activity was detected at early times during viral infection, suggesting AEIO blocks viral entry, particularly membrane fusion (Pradeep et al, 2019).…”

Section: Fungus-derived Compounds With Antiviral Activity Against Hsvmentioning

confidence: 99%

“…Furthermore, an aqueous extract from Inonotus obliquus (AEIO) was shown to inhibit HSV-1 infection in Vero cells (Pradeep et al, 2019). the antiviral activity was detected at early times during viral infection, suggesting AEIO blocks viral entry, particularly membrane fusion (Pradeep et al, 2019).…”

Section: Fungus-derived Compounds With Antiviral Activity Against Hsvmentioning

confidence: 99%

“…Mice treated with GFAHP had a significant reduction in blepharitis, vascularization and stromal disease, as well as reduced viral replication in the cornea (Gu et al, 2007). Notably, the antiviral protein RC28 obtained from the fungus Rozites caperata showed antiviral activity against HSV-1 in Vero cells (Pradeep et al, 2019). Moreover, the authors evaluated the antiviral effect of RC28 in an animal model and observed that this peptide decreased the severity of stromal keratitis (Pradeep et al, 2019).…”

Section: Fungus-derived Compounds With Antiviral Activity Against Hsvmentioning

confidence: 99%

“…Notably, the antiviral protein RC28 obtained from the fungus Rozites caperata showed antiviral activity against HSV-1 in Vero cells (Pradeep et al, 2019). Moreover, the authors evaluated the antiviral effect of RC28 in an animal model and observed that this peptide decreased the severity of stromal keratitis (Pradeep et al, 2019). Table 2 summarizes the antiviral activity of these compounds.…”

Section: Fungus-derived Compounds With Antiviral Activity Against Hsvmentioning

confidence: 99%

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Current Antivirals and Novel Botanical Molecules Interfering With Herpes Simplex Virus Infection

et al. 2020

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Herpes simplex viruses type 1 (HSV-1) and type 2 (HSV-2) are highly prevalent within the human population and are characterized by lifelong infections and sporadic recurrences due to latent neuron infection. Upon reactivations, HSVs may manifest either, symptomatically or asymptomatically and be shed onto others through mucosae body fluids. Although, HSVs can produce severe disease in humans, such as lifethreatening encephalitis and blindness, the most common symptoms are skin and mucosal lesions in the oro-facial and the genital areas. Nucleoside analogs with antiviral activity can prevent severe HSV infection, yet they are not very effective for treating skin manifestations produced by these viruses, as they only reduce in a few days at most the duration of lesions. Additionally, HSV variants that are resistant to these antivirals may arise, especially in immunosuppressed individuals. Thus, new antivirals that can reduce the severity and duration of these cutaneous manifestations would certainly be welcome. Here, we review currently available anti-herpetic therapies, novel molecules being assessed in clinical trials and new botanical compounds reported in the last 20 years with antiviral activities against HSVs that might represent future treatments against these viruses.

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A liquid chromatography–tandem mass spectrometry method development for the quantification of favipiravir drug and its related impurities in rat plasma and its application to pharmacokinetic studies

Koganti,

Amara Babu,

Sattu

et al. 2023

Biomedical Chromatography

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Favipiravir is an antiviral drug used for the treatment of virus‐based diseases such as influenza. In this context, the development of a reliable liquid chromatography–tandem mass spectrometry method for the quantification of the drug and its impurities is necessary, particularly following the COVID‐19 pandemic. Chromatographic separation was achieved on an inertial ODS column using gradient elution with a buffer containing triethylamine in high‐performance liquid chromatography water and adjusting its pH with formic acid. The mixture of buffer and acetonitrile was used as a mobile phase with a flow rate of 1 ml/min at ambient temperature. The separation of favipiravir and its related impurities from remdesivir as an internal standard was achieved. The results indicated that all the variables, like precision, accuracy, linearity, matrix effect and stability, were successfully achieved within the limits of US Food and Drug Administration guidelines. This study could provide a new protocol for the development of new analytical methods for the detection of favipiravir and its impurities.

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Antiviral Potency of Mushroom Constituents

Cited by 11 publications

References 99 publications

Survival of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) and Herpes Simplex Virus 1 (HSV-1) on Foods Stored at Refrigerated Temperature

Survival of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) and Herpes Simplex Virus 1 (HSV-1) on Foods Stored at Refrigerated Temperature

Current Antivirals and Novel Botanical Molecules Interfering With Herpes Simplex Virus Infection

A liquid chromatography–tandem mass spectrometry method development for the quantification of favipiravir drug and its related impurities in rat plasma and its application to pharmacokinetic studies

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