Antiviral Polymers Based on N-Halamine Polyurea

Abstract

N-halamines are a commonly applied class of antimicrobial agents used for a variety of applications relating to human health. Here, we present the modulation of the common polymers polyurea and polyguanidine with the N-halamine technology. The N–H bonds in either polymer were converted to N–Cl or N–Br bonds capable of releasing Cl+ or Br+ cations to aqueous media as antiviral agents. Controlled release of the oxidizing agents was monitored for a period of 4 weeks. Antiviral activity was evaluated against the T4 bacteriophage as well as against the highly stable plant virus belonging to the Tobamovirus genus, tomato brown rugose fruit virus. The incorporation of the N-halamine technology on commonly used polymers has effectively introduced antiviral functionality for a wide variety of potential applications.

Disinfectants role in the prevention of spreading the COVID‐19 and other infectious diseases: The need for functional polymers!

“…The halonium ions linked to these polymers, such as chloronium/bromonium, were released in a controlled manner as studied for 4 weeks. 55 This study paved the way for the development of industrial polymers as disinfectants for the release of bioactive for long‐term antiviral activity in agricultural science.…”

“…In a recent study from the Domb group, polyurea and polyguanidines were converted to N ‐halamine linkages to study their antiviral activity against T4 bacteriophage and tomato brown rugose fruit virus. The halonium ions linked to these polymers, such as chloronium/bromonium, were released in a controlled manner as studied for 4 weeks 55 . This study paved the way for the development of industrial polymers as disinfectants for the release of bioactive for long‐term antiviral activity in agricultural science.…”

“…The polymers containing N ‐halamine functionality release halonium ions, which have a positive charge function as an antiseptic oxidizing agent. 53 , 54 , 55 In a recent study from the Domb group, polyurea and polyguanidines were converted to N ‐halamine linkages to study their antiviral activity against T4 bacteriophage and tomato brown rugose fruit virus. The halonium ions linked to these polymers, such as chloronium/bromonium, were released in a controlled manner as studied for 4 weeks.…”

“…N ‐halamine ( N ‐X; X = Cl/Br/I) functionality containing polymers is gaining popularity among antiviral polymers. The polymers containing N ‐halamine functionality release halonium ions, which have a positive charge function as an antiseptic oxidizing agent 53–55 . In a recent study from the Domb group, polyurea and polyguanidines were converted to N ‐halamine linkages to study their antiviral activity against T4 bacteriophage and tomato brown rugose fruit virus.…”

Microbe Killer Polymeric Films Made by Melt-Compounding and Compression of Peptide Assemblies and Polyethylene

“…13 Recently, it was shown that polyurea and polyguanidine incorporating N-halamine signi cantly inhibited T4 bacteriophage and plant virus associated with the Tobamovirus genus. 14 Another group of materials incorporated into polymers includes metal and metal oxides such as silver titanium oxide and zinc oxide. 15 However, these materials may be toxic and in uence human health.…”