Antiviral Polymer Brushes by Visible-Light-Induced, Oxygen-Tolerant Covalent Surface Coating

Kuzmyn, Andriy R.; Teunissen, Lucas W.; Kroese, M. V.; Kant, Jet; Venema, Sandra; Zuilhof, Han

doi:10.1021/acsomega.2c03214

Cited by 4 publications

(22 citation statements)

References 66 publications

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“…À under green light irradiation 339 or EY in the presence of TEOA under blue 140,340 or green light irradiation 138,341 expanded the polymerization media to aqueous systems. The lack of oxygen tolerance in the absence of TEOA required prior degassing 342 or enzymatic degassing strategy using GOx and glucose.…”

Section: Advanced Techniquesmentioning

confidence: 99%

“…Since then, ZnTPP in combination with DMSO as a solvent has been widely utilized for oxygen-tolerant SI-PET-RAFT polymerization under violet, 335 green, 336–338 or yellow light irradiation. 338 A water-soluble ZnTPPS 4 − under green light irradiation 339 or EY in the presence of TEOA under blue 140,340 or green light irradiation 138,341 expanded the polymerization media to aqueous systems. The lack of oxygen tolerance in the absence of TEOA required prior degassing 342 or enzymatic degassing strategy using GOx and glucose.…”

Section: Pet-raft Polymerizationmentioning

confidence: 99%

Section: Pet-raft Polymerizationmentioning

confidence: 99%

“…Antifouling surfaces were prepared from hydrophilic, zwitterionic ( e.g. , carboxybetaine methacrylamide (CBMAm) 140,340 ), and low-fouling monomers ( e.g. , sulfoxide- 336 or fluorine monomers 337 ) to inhibit adsorption of biomolecules such as bacteria, proteins, and cells.…”

Section: Pet-raft Polymerizationmentioning

confidence: 99%

“…The lack of oxygen tolerance in the absence of TEOA required prior degassing 342 or enzymatic degassing strategy using GOx and glucose. 163 Using these various PCs, SI-PET-RAFT polymerization has been employed for fabrication of antifouling surfaces for biomedical and industrial applications, 138,140,[336][337][338]340 polycarbonate surface with tuned hydrophilicity, 339 organic-inorganic hybrid materials, 235,[341][342][343][344] and functional polymeric materials. 335 Antifouling surfaces were prepared from hydrophilic, zwitterionic (e.g., carboxybetaine methacrylamide (CBMAm) 140,340 ), and low-fouling monomers (e.g., sulfoxide- 336 or fluorine monomers 337 ) to inhibit adsorption of biomolecules such as bacteria, proteins, and cells.…”

Section: Or Yellow Lightmentioning

confidence: 99%

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Photocontrolled RAFT polymerization: past, present, and future

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Section: Advanced Techniquesmentioning

confidence: 99%

Section: Pet-raft Polymerizationmentioning

confidence: 99%

Section: Pet-raft Polymerizationmentioning

confidence: 99%

Section: Pet-raft Polymerizationmentioning

confidence: 99%

Section: Or Yellow Lightmentioning

confidence: 99%

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Photocontrolled RAFT polymerization: past, present, and future

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19 nm‐Thick Grafted‐To Polymer Brushes onto Optimized Poly(Dopamine)‐Coated Surfaces

Teunissen

Smulders

Zuilhof

2023

Adv Materials Inter

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to carefully consider the interactions of the device's interfaces with the complex media it is subjected to. The type of interactions and their extent can be effectively controlled by modification of the surface using polymer chains. Polymer brush coatings, in particular, can be employed to introduce specific surface properties with great accuracy due to extensive control over variables such as brush thickness, grafting density, polymer architecture, and functional groups. [4][5][6] Polymer brush coatings have therefore been used to equip surfaces with, e.g., antifouling, [7][8][9][10][11][12][13][14] lubricating, [15] and/or (thermo)responsive properties. [16] Polymer brushes are most commonly synthesized by a grafting-from procedure, in which the chains are grown bottom-up from surface-bound initiators. [17,18] This approach is primarily selected because high grafting densities and brush thicknesses can be readily achieved. Additionally, the advent of surface-initiated, controlled polymerization techniques that allow for both the presence of water and oxygen has greatly expanded the potential of grafting-from approaches. [10,[19][20][21][22] However, polymer brushes obtained via surface-initiated polymerization are difficult to characterize, and detailed analysis would optimally involve degrafting of the polymer chains. Degrafting reactions typically require harsh conditions that may damage the polymers and, in addition, large surface areas are needed to obtain sufficient amounts of detached polymer for detailed analysis. [23,24] The primary alternative synthesis route toward polymer brushes is the grafting-to approach. [25] This strategy involves the synthesis of desired polymers in solution followed by their attachment to the target substrate. In contrast with surfacegrown polymers, characterization of solution-grown polymers can be easily performed using straightforward analysis techniques. As a result, valuable information such as polymer molecular weight, polydispersity, and, after immobilization, the grafting density of the polymer brush can be routinely determined. The major disadvantage to the grafting-to strategy is the inherent limitation in attainable layer thicknesses, which generally do not exceed 10 nm. [26] That limitation is at least partially the result of the excluded volume of each polymer chain on the surface, which hinders subsequent, incoming polymers to reach reactive sites on the surface. This thickness limitation might hamper several applications, such as optimal antifouling and self-healing performance, and as such is a highly desirable Grafting-to polymer coatings are typically easy to apply, but the thickness of such coatings is typically limited to a few nanometers, which may hamper applications. This paper presents a grafting-to coating approach that yields polymer brushes up to an unprecedented thickness of 19 nm. To this aim, an easy-to-apply poly(dopamine) (PDA) primer layer is optimized. PDA is an easy-to-apply, but highly complex and chemically not well understood primer layer...

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Tunable Cell-Adhesive Surfaces by Surface-Initiated Photoinduced Electron-Transfer-Reversible Addition–Fragmentation Chain-Transfer Polymerization

Kuzmyn,

Ypma,

Zuilhof

2024

Langmuir

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Cell adhesion involves many interactions between various molecules on the cell membrane (receptors, coreceptors, integrins, etc.) and surfaces or other cells. Cell adhesion plays a crucial role in the analysis of immune response, cancer treatment, tissue engineering, etc. Cell−cell adhesion can be quantified by measuring cell avidity, which defines the total interaction strength of the live cell binding. Typically, those investigations use tailor-made, reusable chips or surfaces onto which cells are cultured to form a monolayer to which other cells can bind. Cell avidity can then be measured by applying a force and quantifying cell−cell bond ruptures. The subsequent cleaning and reactivation of such biochip and biointeractive surfaces often require repeated etching, leading to device damage. Furthermore, it is often of great interest to harvest the cells that remain bound at the end of an avidity experiment for further analysis or use. It is, therefore, advantageous to pursue coating methods that allow tunable cell adhesion. This work presents temperature-switchable poly(di(ethylene glycol) methyl ether methacrylate) brush-based cell-interactive coatings produced by surface-initiated photoinduced electron-transfer reversible addition−fragmentation chain-transfer polymerization. The temperature switch of these brushes was explored by using a quartz crystal microbalance with dissipation monitoring, chemical composition, and physicochemical properties by atom force microscopy, X-ray photoelectron spectroscopy, single-molecule force spectroscopy, and ellipsometry.

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Antiviral Polymer Brushes by Visible-Light-Induced, Oxygen-Tolerant Covalent Surface Coating

Cited by 4 publications

References 66 publications

Photocontrolled RAFT polymerization: past, present, and future

Photocontrolled RAFT polymerization: past, present, and future

19 nm‐Thick Grafted‐To Polymer Brushes onto Optimized Poly(Dopamine)‐Coated Surfaces

Tunable Cell-Adhesive Surfaces by Surface-Initiated Photoinduced Electron-Transfer-Reversible Addition–Fragmentation Chain-Transfer Polymerization

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