Antiviral plant-derived natural products to combat RNA viruses: Targets throughout the viral life cycle

Owen, Lucy; Laird, Katie; Shivkumar, Maitreyi

doi:10.1111/lam.13637

Cited by 30 publications

(22 citation statements)

References 118 publications

(238 reference statements)

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“…Because the development of effective BSAAs remains a challenging task in drug discovery, natural products have been considered as a unique source of chemical complexity and diversity within which antiviral activities can be identified. Indeed, an increasing body of evidence, based on robust molecular, biochemical and pharmacological studies, indicates that a wide-range of natural products derived from plants show inhibitory effects on the replication of many different viruses, thus having the potential to be deployed as BSAAs against both current viruses and new emerging viral threats [ 8 , 9 , 10 ]. The bioactive components of some of these plant extracts endowed with antiviral activity have been identified as specific polyphenols, flavonoids, glucosides, terpenes, and alkaloids, and the mechanisms of action and molecular targets for some of these molecules have been elucidated [ 11 , 12 ].…”

Section: Introductionmentioning

confidence: 99%

Tackling the Future Pandemics: Broad-Spectrum Antiviral Agents (BSAAs) Based on A-Type Proanthocyanidins

2022

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A-type proanthocyanidins (PAC-As) are plant-derived natural polyphenols that occur as oligomers or polymers of flavan-3-ol monomers, such as (+)-catechin and (−)-epicatechin, connected through an unusual double A linkage. PAC-As are present in leaves, seeds, flowers, bark, and fruits of many plants, and are thought to exert protective natural roles against microbial pathogens, insects, and herbivores. Consequently, when tested in isolation, PAC-As have shown several biological effects, through antioxidant, antibacterial, immunomodulatory, and antiviral activities. PAC-As have been observed in fact to inhibit replication of many different human viruses, and both enveloped and non-enveloped DNA and RNA viruses proved sensible to their inhibitory effect. Mechanistic studies revealed that PAC-As cause reduction of infectivity of viral particles they come in contact with, as a result of their propensity to interact with virion surface capsid proteins or envelope glycoproteins essential for viral attachment and entry. As viral infections and new virus outbreaks are a major public health concern, development of effective Broad-Spectrum Antiviral Agents (BSAAs) that can be rapidly deployable even against future emerging viruses is an urgent priority. This review summarizes the antiviral activities and mechanism of action of PAC-As, and their potential to be deployed as BSAAs against present and future viral infections.

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Section: Introductionmentioning

confidence: 99%

Tackling the Future Pandemics: Broad-Spectrum Antiviral Agents (BSAAs) Based on A-Type Proanthocyanidins

2022

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“…Viruses pose a serious challenge to the health and quality of life of humans. Their general spread and rapid mutation has severely compromised the efficacy of antiviral drugs, thereby stimulating research and development of new antiviral drugs ( Owen et al, 2022 ).…”

Section: Discussionmentioning

confidence: 99%

Research progress on the antiviral activities of natural products and their derivatives: Structure–activity relationships

Guo

Ma²,

Wang³

et al. 2022

Front. Chem.

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Viruses spread rapidly and are well-adapted to changing environmental events. They can infect the human body readily and trigger fatal diseases. A limited number of drugs are available for specific viral diseases, which can lead to non-efficacy against viral variants and drug resistance, so drugs with broad-spectrum antiviral activity are lacking. In recent years, a steady stream of new viral diseases has emerged, which has prompted development of new antiviral drugs. Natural products could be employed to develop new antiviral drugs because of their innovative structures and broad antiviral activities. This review summarizes the progress of natural products in antiviral research and their bright performance in drug resistance issues over the past 2 decades. Moreover, it fully discusses the effect of different structural types of natural products on antiviral activity in terms of structure–activity relationships. This review could provide a foundation for the development of antiviral drugs.

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“…Plants have been used as traditional medicines for both communicable and non-communicable diseases for centuries. Since the advent of modern drug discovery techniques, plants with medicinal value have been studied for being novel therapeutic agents [ 7 , 8 ]. India, China, and South Korea are among the countries that have issued guidelines on traditional regimens for the prevention and management of COVID-19 [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

Plant-derived immuno-adjuvants in vaccines formulation: a promising avenue for improving vaccines efficacy against SARS-CoV-2 virus

et al. 2022

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The SARS-CoV-2 outbreak has posed a plethora of problems for the global healthcare system and socioeconomic burden. Despite valiant efforts to contain the COVID-19 outbreak, the situation has deteriorated to the point that there are no viable preventive therapies to treat this disease. The case count has skyrocketed globally due to the newly evolved variants. Despite vaccination drives, the re-occurrence of recent pandemic waves has reinforced the importance of innovation/utilization of immune-booster to achieve appropriate long-term vaccine protection. Plant-derived immuno-adjuvants, which have multifaceted functions, can impede infections by boosting the immune system. Many previous studies have shown that formulation of vaccines using plant-derived adjuvant results in long-lasting immunity may overcome the natural tendency of coronavirus immunity to wane quickly. Plant polysaccharides, glycosides, and glycoprotein extracts have reportedly been utilized as enticing adjuvants in experimental vaccines, such as Advax, Matrix-M, and Mistletoe lectin, which have been shown to be highly immunogenic and safe. When employed in vaccine formulation, Advax and Matrix-M generate long-lasting antibodies, a balanced robust Th1/Th2 cytokine profile, and the stimulation of cytotoxic T cells. Thus, the use of adjuvants derived from plants may increase the effectiveness of vaccines, resulting in the proper immunological response required to combat COVID-19. A few have been widely used in epidemic outbreaks, including SARS and H1N1 influenza, and their use could also improve the efficacy of COVID-19 vaccines. In this review, the immunological adjuvant properties of plant compounds as well as their potential application in anti-COVID-19 therapy are thoroughly discussed.

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Antiviral plant-derived natural products to combat RNA viruses: Targets throughout the viral life cycle

Cited by 30 publications

References 118 publications

Tackling the Future Pandemics: Broad-Spectrum Antiviral Agents (BSAAs) Based on A-Type Proanthocyanidins

Tackling the Future Pandemics: Broad-Spectrum Antiviral Agents (BSAAs) Based on A-Type Proanthocyanidins

Research progress on the antiviral activities of natural products and their derivatives: Structure–activity relationships

Plant-derived immuno-adjuvants in vaccines formulation: a promising avenue for improving vaccines efficacy against SARS-CoV-2 virus

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