Antiviral Nucleosides Flu Viruses Quinolines Covid-19

Abstract

Chloroquine (Aralen®) is indicated for the treatment of malaria and extraintestinal amebiasis. Hydroxychloroquine (Plaquenil®) is also prescribed for the treatment of malaria. It is also used successfully to treat lupus erythematosus and rheumatoid arthritis. In addition, it should be noted that chloroquine, essentially, and hydroxychloroquine, to a lesser extent, have been clinically tested for their anti-HIV activity [1][2][3][4] We have recently developed several processes leading to known antiviral agents starting with guanosine. The processes involve enzymatic transglycosylation for stavudine (d4T), chemical trans urination for acyclovir and ganciclovir, and novel alkylau on for penciclovir and famciclovir. Firstly, and influenza viruses have a similar disease presentation. That is, they both cause respiratory disease, which presents as a wide range of illness from asymptomatic or mild through to severe disease and death. Secondly, both viruses are transmitted by contact, droplets and fomites. As a result, the same public health measures, such as hand hygiene and good respiratory etiquette (coughing into your elbow or into a tissue and [1,8-10] immediately disposing of the tissue), are important actions all can take to prevent infection. Human H1N1 pandemic developed from the originally localized Mexican source early in the spring 2009. For the emergency created by the epidemic of « influence of the pigs » in Mexico it was correct not to create alarmismes being victims of a bad information. Cytokine storm should be entioned asone of the key pathogenic events contributing to the overall mortality in substantial portion of patients. If active immunization is assumed to be preventive measure of proven efficacy, clinicians are still in doubt how to treat a complicated course of infection. The possibility that the virus arrives in other parts of the world is real as for all the types of influence virus. In order that a strain has a wide distribution, its antigenic characteristics must ensure that it escapes the neutralization of antibodies of the host and of the surrounding population. So, the outbreaks will happen with those strains that have dominant antigens that fit the deficiency, or better, the absences of antibody in the population [11][12][13][14][15].It seems, in conclusion that the flu virus shows an ability and an aptitude for survival built on the possibility of emergence of new models that allow the virus being confused easily through populations still partly immune to previous antigenic forms. According to this view, the changes in the influenza A can be designed in single meaning, in the context of a principle and of an evolutionary progress, from Burnet said immunological drift or steering immunology. The antiviral drugs (inhibitors of the neuraminidasis, receptor of the virus Crimson PublishersWings to the Research