Antiviral interferons induced by Newcastle disease virus (NDV) drive a tumor-selective apoptosis

Ginting, Teridah Ernala; Christian, Salomo; Larasati, Young Othiwi; Suriapranata, Ivet; Mathew, George

doi:10.1038/s41598-019-51465-6

Cited by 21 publications

(18 citation statements)

References 47 publications

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“…The CaIFNs use in this study was isolated in our previous study [16] and it was proven had an antiproliferation activity on tumor cell lines. Our natural CaIFN isolate was produced by the inductions of Newcastle disease virus (NDV) on normal and tumor-derived cell lines similar to those prepared by another researcher [23], while the rCaIFN was produced in the silkworm Bombyx mori system as other's study [22].…”

Section: Discussionmentioning

confidence: 99%

In vitro antiproliferation activity of Typhonium flagelliforme leaves ethanol extract and its combination with canine interferons on several tumor-derived cell lines

et al. 2020

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Background and Aim: Tumor disorder is one of the degenerative diseases that affected human and animals and recently is tend to increase significantly. The treatment of tumor diseases can be performed through surgical, chemotherapy, radiotherapy, biological substances, and herbs medicine. Typhonium flagelliforme leaves extract known to have an antiproliferation activity, while interferons (IFNs) one of the cytokines that first used as an antiviral agent was also known to have antitumor activity. Nowadays, the treatment of tumors using a traditional way, including the use of herbal substances, becomes popular. Some limitations of the antitumor activity due to resistant development of the cell to some substances were one of the problems on why the treatment of cancer was unsuccessful. This study aimed to elaborate the synergistic effect on the antiproliferation and anti-angiogenesis activities of the combinations between T. flagelliforme leaves ethanol extract and canine natural (natural canine IFN [nCaIFN]) and recombinant (recombinant canine IFN [rCaIFN]) IFNs on tumor-derived cell lines to find the new potential antitumor substances. Materials and Methods: The extraction of T. flagelliforme leaves was performed using the maceration method and followed by phytochemical screening assays. According to the result of LC50 by the brine shrimp lethality test, the dose used for T. flagelliforme extract was 120 ppm while the dose of IFNs was 102 U/ml. The tumor-derived cell lines (canine squamous cell carcinoma [CSCC], canine mammary gland benign mixed tumor/MCM-IPB-B3, and feline squamous cell carcinoma [FSCC]) and normal rabbit endothelial cells were cultured and maintained on Dulbecco's Modified Eagle's Medium DMEM/Ham-F12 medium supplemented with 10% fetal calf serum, antibiotic, and antifungal. The antiproliferation activity was assayed by calculated the total cell number after treated with the tested substances. The antiangiogenesis assay was performed using in vitro method on rabbit normal endothelial cells and in ovo using chicken chorioallantoic membrane (CAM). Results: The phytochemical screening test of the T. flagelliforme leaves ethanol extract indicated that the compound consisted of flavonoid, steroid, and tannin. The antiproliferation activity was increased in the combination of substances compared to the single exposure of each substance on all tested tumor-derived cell lines. There was no significantly different on the antiproliferation activity between a combination of T. flagelliforme with nCaIFN or rCaIFN in every single tested cell lines, but the comparison of this activity among the three tumor-derived cell lines seem that the antiproliferation activity is more effective on CSCC cell lines compared to the canine mammary gland benign mixed tumor and FSCC cell lines. A similar pattern of synergistic effect was also detected on the anti-angiogenesis activity in vitro using rabbit endothelial cells as well as in ovo assays. The most effective of the in vitro and in ovo anti-angiogenesis activity was observed on the combination substances between T. flagelliforme extract and rCaIFN compared to other treatments. Conclusion: There was a synergistic effect on the antiproliferation and antiangiogenesis activities of the combination between T. flagelliforme and canine IFNs (natural and recombinant) and this result could be developed as another alternative on the cancer treatments.

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Section: Discussionmentioning

confidence: 99%

In vitro antiproliferation activity of Typhonium flagelliforme leaves ethanol extract and its combination with canine interferons on several tumor-derived cell lines

et al. 2020

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“…PAMPs are very common in pathogenic bacteria and viruses, including viral capsids, DNA, RNA, and viral protein products. For example, the RNA helicases RIGI and TLR3 recognize dsRNA, leading to the activation of interferon regulatory factor (IRF) 3, IRF 9 and nuclear factor kappa B (NF-κB) and subsequent production and release of type I/III IFN [22][23][24]. IFN then activates host cells in an autocrine manner and activates surrounding cells in a paracrine manner to synthesize antiviral proteins, thus terminating the synthesis of cellular proteins and promoting rapid cell death and virus clearance.…”

Section: Ndv As a Cancer Vaccinementioning

confidence: 99%

Advances in the Study of Antitumour Immunotherapy for Newcastle Disease Virus

Meng¹,

He²,

Zhong³

et al. 2021

Int. J. Med. Sci.

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This article reviews the preclinical research, clinical application and development of Newcastle disease virus (NDV) in the field of cancer therapy. Based on the distinctive antitumour properties of NDV and its positive interaction with the patient's immune system, this biologic could be considered a major breakthrough in cancer treatment. On one hand, NDV infection creates an inflammatory environment in the tumour microenvironment, which can directly activate NK cells, monocytes, macrophages and dendritic cells and promote the recruitment of immune cells. On the other hand, NDV can induce the upregulation of immune checkpoint molecules, which may break immune tolerance and immune checkpoint blockade resistance. In fact, clinical data have shown that NDV combined with immune checkpoint blockade can effectively enhance the antitumour response, leading to the regression of local tumours and distant tumours when injected, and this effect is further enhanced by targeted manipulation and modification of the NDV genome. At present, recombinant NDV and recombinant NDV combined with immune checkpoint blockers have entered different stages of clinical trials. Based on these studies, further research on NDV is warranted.

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“…Utilizing NDV as an antitumor therapy is an ongoing research, and not yet a full therapeutic product [33,34].…”

Section: Ndv As An Oncolytic Agentmentioning

confidence: 99%

Newcastle Disease Virus

Haddas¹

2020

Encyclopedia of Sustainability Science and Technology

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Antiviral interferons induced by Newcastle disease virus (NDV) drive a tumor-selective apoptosis

Cited by 21 publications

References 47 publications

In vitro antiproliferation activity of Typhonium flagelliforme leaves ethanol extract and its combination with canine interferons on several tumor-derived cell lines

In vitro antiproliferation activity of Typhonium flagelliforme leaves ethanol extract and its combination with canine interferons on several tumor-derived cell lines

Advances in the Study of Antitumour Immunotherapy for Newcastle Disease Virus

Newcastle Disease Virus

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