Antiviral insulin signaling during West Nile virus infection results in viral mutations
Aditya B. Char,
Chasity E. Trammell,
Stephen Fawcett
et al.
Abstract:Arthropod-borne viruses or arboviruses, including West Nile virus (WNV), dengue virus (DENV), and Zika virus (ZIKV) pose significant threats to public health. It is imperative to develop novel methods to control these mosquito-borne viral infections. We previously showed that insulin/insulin-like growth factor-1 signaling (IIS)-dependent activation of ERK and JAK-STAT signaling has significant antiviral activity. Continuous immune pressure can lead to adaptive mutations of viruses during infection. We aim to e… Show more
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