Antiviral Evaluation of Dispirotripiperazines against Hepatitis B Virus
Thane Jones,
John E. Tavis,
Qilan Li
et al.
Abstract:Hepatitis B virus (HBV) is a hepatotropic DNA virus that
replicates
by reverse transcription. It chronically infects >296 million people
worldwide, including ∼850,000 in the USA, and kills 820,000
annually worldwide. Current nucleos(t)ide analogue (NA) or pegylated
interferon α therapies do not eradicate the virus and would
benefit from a complementary antiviral drug. We performed a preliminary
screen of 28 dispirotripiperazines against HBV, identifying 9 hits
with EC50 of 0.7–25 μM. Compound 11826096
displa… Show more
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