Antiviral Effect of Resveratrol in Piglets Infected with Virulent Pseudorabies Virus

Zhao, Xinghong; Wu, Tong; Song, Xu; Jia, Renyong; Li, Lixia; Zou, Yuanfeng; He, Chao; Liang, Xiaoxia; Lü, Cheng; Jing, Bo; Lin, Johnson; Yin, Lizi; Ye, Gang; Yue, Guizhou; Wang, Yin

doi:10.3390/v10090457

Cited by 47 publications

(45 citation statements)

References 34 publications

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“…Resveratrol is a natural compound and antioxidant found in peanuts, soy, hop, and various fruits, especially grapes and red wines [27, 28]. Resveratrol possesses various biological activities, including anti-tumour, anti-viral, anti-inflammation, anti-fungal, and antibacterial effects [27, 29-32]. We have demonstrated that resveratrol increases the expression of activating receptors on NK cells (Fig.…”

Section: Discussionmentioning

confidence: 99%

In vivo Anti-Cancer Effects of Resveratrol Mediated by NK Cell Activation

2020

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Natural killer (NK) cells are innate immune lymphocytes that play an important role in anti-viral and anti-tumour immune responses. Several cancer immunotherapy approaches targeting NK cells are currently in clinical or preclinical development. Here, we aimed to find food nutrients that activate NK cells and determine their usefulness as candidates for anti-cancer and anti-metastatic drugs. Resveratrol appeared to activate NK cells most effectively among the substances tested and synergistically increased IFN-γ secretion and NK cell cytotoxicity with interleukin-2 (IL-2). CD107a, NKp30, and NKG2D expression levels were upregulated on the surface of NK cells upon treatment with resveratrol in combination with IL-2 compared with treatment with IL-2 alone. Moreover, NK cell activity in human and mouse whole blood was enhanced upon treatment with resveratrol. Most importantly, administration of resveratrol effectively inhibited tumour growth and metastasis in mice. In conclusion, we suggest that resveratrol may represent a candidate anti-cancer drug that acts by activating NK cells in vivo.

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Section: Discussionmentioning

confidence: 99%

In vivo Anti-Cancer Effects of Resveratrol Mediated by NK Cell Activation

2020

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“…Pseudorabies virus is one of the devastating pathogen of swine for which there is no treatment and that often result in economic losses. Resveratrol showed antiviral activity by inhibiting the Pseudorabies virus replication and effectively increase the growth performance and reduce the mortality of Pseudorabies virus-infected piglets [ 108 ].…”

Section: Biological Activities Of Resveratrolmentioning

confidence: 99%

Resveratrol: A Double-Edged Sword in Health Benefits

et al. 2018

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Resveratrol (3,5,4′-trihydroxy-trans-stilbene) belongs to polyphenols’ stilbenoids group, possessing two phenol rings linked to each other by an ethylene bridge. This natural polyphenol has been detected in more than 70 plant species, especially in grapes’ skin and seeds, and was found in discrete amounts in red wines and various human foods. It is a phytoalexin that acts against pathogens, including bacteria and fungi. As a natural food ingredient, numerous studies have demonstrated that resveratrol possesses a very high antioxidant potential. Resveratrol also exhibit antitumor activity, and is considered a potential candidate for prevention and treatment of several types of cancer. Indeed, resveratrol anticancer properties have been confirmed by many in vitro and in vivo studies, which shows that resveratrol is able to inhibit all carcinogenesis stages (e.g., initiation, promotion and progression). Even more, other bioactive effects, namely as anti-inflammatory, anticarcinogenic, cardioprotective, vasorelaxant, phytoestrogenic and neuroprotective have also been reported. Nonetheless, resveratrol application is still being a major challenge for pharmaceutical industry, due to its poor solubility and bioavailability, as well as adverse effects. In this sense, this review summarized current data on resveratrol pharmacological effects.

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“…3). In the antiviral effects of resveratrol in piglets infected with PRV, resveratrol can signi cantly inhibit the virus titer in the brain, and the levels of viral copies in the brain were positively linked to the clinical parameters of infected piglets [44]. Kaempferol were found effective to delay and inhibit the clinical symptoms in the PRVinfected mice which may attributed to inhibition of virus replication in the brain.…”

Section: Discussionmentioning

confidence: 93%

“…PRV (Ra strain) were preserved in the Natural Medicine Research Center Sichuan Agricultural University (Chengdu, China) [44], and the 50% tissue culture infective dose (TCID 50 ) was determined as 10 − 7.43 /mL. The virus was diluted to 1 × 10 4 TCID 50 with PBS before use.…”

Section: Virus and Chemicalsmentioning

confidence: 99%

The Antiviral Activity of Kaempferol Against Pseudorabies Virus in Mice

Wang

Chen

et al. 2020

Preprint

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Background: Pseudorabies virus (PRV), a member of the neurotrophic Alphaherpesviruses, is one of the most important pathogens that harm the global pig industry. Accumulated evidence indicated that PRV could infect humans under certain circumstances, inducing severe clinical symptoms such as acute human encephalitis. Currently, there are no antiviral drugs to treat PRV infections, and vaccines available only for swine could not provide full protections. Thus, new control measures are urgently needed. Results: In the present study, kaempferol exhibited anti-PRV activity in mice through improving survival rate by 22.22% at 6 days post infection (dpi) which is higher than acyclovir (Positive control) with the survival rate of 16.67%, and in the infected-untreated group the survival rate was 0%. Kaempferol could inhibit the virus replication in the brain, lung, kidney, heart and spleen, especially in the brain the viral gene copies were reduced by over 700-fold, which is further confirmed by immunohistochemical examination. The tissue lesions induced by PRV infection in these organs were also alleviated. The expressions of the early genes EPO and TK in the brain were significantly inhibited by kaempferol. The expression of latency-associated transcript (LAT) were also inhibited in the brain, which suggested kaempferol could inhibit the PRV latency. Kaempferol-treatment could induce higher levels of IL-1β, IL-4, IL-6, TNF-α and IFN-γ in the serum at 3 dpi which were then declined to normal levels at 5 dpi, suggesting that kaempferol could exert anti-PRV activity through regulation of the immune function.Conclusions: These results suggest that kaempferol is expected to be a new alternative control measure for PRV infections.

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Antiviral Effect of Resveratrol in Piglets Infected with Virulent Pseudorabies Virus

Cited by 47 publications

References 34 publications

In vivo Anti-Cancer Effects of Resveratrol Mediated by NK Cell Activation

In vivo Anti-Cancer Effects of Resveratrol Mediated by NK Cell Activation

Resveratrol: A Double-Edged Sword in Health Benefits

The Antiviral Activity of Kaempferol Against Pseudorabies Virus in Mice

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