Antiviral drugs: Present status and future prospects

Sus, I.Heleen van der; Wiltink, E. H. H.

doi:10.1016/0020-711x(94)90161-9

Cited by 6 publications

(2 citation statements)

References 28 publications

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“…To avoid these side-effects, there is a need for producing non-nucleoside inhibitors. It would be rational to assume that the compounds extracted from plants having the non-nucleoside properties, can be used in anti-retroviral treatment [15].…”

Section: Introductionmentioning

confidence: 99%

Probing the Pharmacological Binding Properties, and Reactivity of Selective Phytochemicals as Potential HIV-1 protease Inhibitors

2019

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The HIV-1 protease plays an essential role in the replication cycle of HIV-1; therefore there is a direct need to develop novel inhibitors of the HIV-1 protease, which can cease the viral replication. The present study targets the discovery of potential inhibitors of HIV-1 protease from a set of phytochemicals. From 2505 phytochemicals, 108 compounds were docked, after screening, with the HIV-1 protease to analyze their inhibitory potential against the protease. DFT analysis was also conducted to study the reactivity of strongly docked compounds. Out of 108 phytochemicals, 38 compounds showed binding affinity greater than the desired threshold. Reactivity of these 38 inhibitors was also high as compared to other compounds, based on the DFT results. These results suggest that the selected 38 phytochemicals are drug candidates and they have the potential to be effectively used against HIV in the future.

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Section: Introductionmentioning

confidence: 99%

Probing the Pharmacological Binding Properties, and Reactivity of Selective Phytochemicals as Potential HIV-1 protease Inhibitors

2019

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“…In compairison to the large numbers of antimicrobial agents against bacteria, few effective antiviral drugs have been developed (1,2). The most widely used approach to the discovery of antiviral agents has been the empirical screening of chemically diverse classes of synthetic and natural compounds for the ability to inhibit virus replication (2,3).…”

mentioning

confidence: 99%

Isolation of virus-neutralizing RNAs from a large pool of random sequences.

Pan

Craven

Qiu

et al. 1995

Proc. Natl. Acad. Sci. U.S.A.

112

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RNA and ribonuclease-resistant RNA analogs that bound and neutralized Rous sarcoma virus (RSV) were isolated from a large pool of random sequences by multiple cycles of in vitro selection using infectious viral particles. The selected RNA pool of RSV-binding sequences at a concentration of 0.16 ,uM completely neutralized the virus. Of 19 sequences cloned from the selected pool, 5 inhibited RSV infection. The selected RNA and RNA analogs were shown to neutralize RSV by interacting with the virus, rather than by adversely affecting the host cells. The selection of the anti-RSV RNA and RNA analogs by intact virions immediately suggests the potential application of this approach to develop RNA and RNA analogs as inhibitors of other viruses such as human immunodeficiency virus.

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Epidemiologic Concepts and Methods

Kaslow

Evans

1997

Viral Infections of Humans

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Antiviral drugs: Present status and future prospects

Cited by 6 publications

References 28 publications

Probing the Pharmacological Binding Properties, and Reactivity of Selective Phytochemicals as Potential HIV-1 protease Inhibitors

Probing the Pharmacological Binding Properties, and Reactivity of Selective Phytochemicals as Potential HIV-1 protease Inhibitors

Isolation of virus-neutralizing RNAs from a large pool of random sequences.

Epidemiologic Concepts and Methods

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