Antiviral drugs in wastewater are on the rise as emerging contaminants: A comprehensive review of spatiotemporal characteristics, removal technologies and environmental risks

Wang, Ruming; Luo, Jun; Li, Chunxing; Chen, Jiamiao; Zhu, Nanwen

doi:10.1016/j.jhazmat.2023.131694

Cited by 19 publications

(7 citation statements)

References 105 publications

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“…This approach has become particularly relevant given the mounting environmental concerns and economic constraints confronting healthcare systems globally. Prior studies have focused on the pharmacodynamics and pharmacokinetics of antiviral agents, often overlooking the extensive ecological and economic implications linked to their widespread application [8,23,24]. Through eco-pharmaco-economic analysis, nuanced distinctions among the leading antiviral chemicals were revealed.…”

Section: Figurementioning

confidence: 99%

“…The development of antiviral resistance, as observed in HIV and seasonal influenza strains, underscores the adaptability of viruses and the limitations of the existing therapeutic approaches [4][5][6]. The recent COVID-19 pandemic has highlighted the urgent need for robust, sustainable, and accessible antiviral therapies [7,8]. Although chemical disinfectants, antiviral drugs, and phytochemicals have shown promise in targeting various stages of viral infections [9,10], the development of resistance and environmental challenges poses significant hurdles to their sustainability [4,8].…”

Section: Introductionmentioning

confidence: 99%

“…The recent COVID-19 pandemic has highlighted the urgent need for robust, sustainable, and accessible antiviral therapies [7,8]. Although chemical disinfectants, antiviral drugs, and phytochemicals have shown promise in targeting various stages of viral infections [9,10], the development of resistance and environmental challenges poses significant hurdles to their sustainability [4,8]. This short communication was aimed to assess the antiviral efficacy and sustainability of chemical disinfectants against major human pathogenic viruses using computational evaluations of disinfectant categories targeting viral structural proteins.…”

Section: Introductionmentioning

confidence: 99%

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In-Silico Assessment of Chemical Disinfectants on Surface Proteins Unveiled Dissimilarity in Antiviral Efficacy and Suitability Towards Pathogenic Viruses

Zure,

Sung,

Rahim

et al. 2024

Preprint

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Viral pathogens pose a substantial threat to public health and necessitate the development of effective remediation and antiviral strategies. This short communication aimed to investigate the antiviral efficacy of disinfectants on the surface proteins of human pathogenic viruses. Using in silico modeling, ligand binding energies (LBEs) of selected disinfectants were predicted and combined with their environmental impacts and costs through eco-pharmaco-economic analysis (EPEA). Results revealed the binding affinities of chemical disinfectants to viral proteins varied significantly (p

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Section: Figurementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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In-Silico Assessment of Chemical Disinfectants on Surface Proteins Unveiled Dissimilarity in Antiviral Efficacy and Suitability Towards Pathogenic Viruses

Zure,

Sung,

Rahim

et al. 2024

Preprint

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“…Anthropogenic micropollutants are a broad and chemically heterogeneous group of environmental pollutants, in which residues of various types of pharmaceuticals play a particular role. Their common feature is that they occur in the environment in low concentrations ranging from the level of ng/L to μg/L (Wang et al, 2023), but even at such concentrations they have biological activity and pose a potential threat to living organisms. There are several routes for drugs and their metabolites to infiltrate the aquatic environment, but wastewater treatment plants are often recognized as the principal focal source (Kumar et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

Solar Light-Driven Degradation of Isoprinosine – Efficiency of the Processes and Kinetic Calculations

Ahmed,

Felis

2024

J. Ecol. Eng.

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The photocatalytic degradation of the antiviral drug Isoprinosine (inosine pranobex, IPN) by TiO 2 -P25, ZnO and SnO 2 was investigated in two different aquatic matrices, i.e. milli-Q-water (MQ) and tap water (TW) under solar irradiation of 500 W/m 2 . The changes in concentration of IPN during all experiments were monitored using HPLC at a wavelength of 260 nm, and the photocatalytic degradation of IPN followed pseudo-first-order kinetics. The highest value of the pseudo-first-order rate constant of IPN photodegradation (k) was obtained by the presence of 20 mg/l TiO 2 -P25, (k = 0.0483 min -1 ) in MQ water with the value of the coefficient of determination (R 2 ) equal to 0.9268. The study also assessed the impact of photocatalyst doses and initial IPN concentrations on the efficacy of IPN photodegradation. The results showed that IPN was resistant to degradation under only sunlight (without any photocatalysts addition), with a degradation rate of 9% after 2 hours in milli-Q water and 16% after 2 hours in tap water. However, the addition of selected photocatalysts resulted in the breakdown of the IPN molecule. TiO 2 -P25 was particularly promising among the tested photocatalysts. The research also discovered that IPN partially adsorbed to TiO 2 particles (33% after 2 hours), ZnO particles (26% after 2 hours), and SnO 2 (4% after 2 hours). Based on the findings, solar-light-driven photocatalysis could be a promising technique for the degradation of certain antiviral drugs in water matrices after optimizing the process.

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“…In the realm of water source recycling, the occurrence of trace organic pollutants in wastewater, their intricate interactions during treatment processes, and their consequential impacts on wastewater treatment and fresh water generation represent pivotal challenges [ 5 ]. As we delve into these challenges, it becomes evident that the unregulated release of novel pollutants, commonly referred to as emerging contaminants (ECs), has emerged as a pressing environmental concern [ 6 , 7 , 8 , 9 ].…”

Section: Introductionmentioning

confidence: 99%

Recent Advances in Black Phosphorous-Based Photocatalysts for Degradation of Emerging Contaminants

Zhang,

He,

Zhang

et al. 2023

Toxics

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The recalcitrant nature of emerging contaminants (ECs) in aquatic environments necessitates the development of effective strategies for their remediation, given the considerable impacts they pose on both human health and the delicate balance of the ecosystem. Semiconductor-based photocatalytic technology is recognized for its dual benefits in effectively addressing both ECs and energy-related challenges simultaneously. Among the plethora of photocatalysts, black phosphorus (BP) stands as a promising nonmetallic candidate, offering a host of advantages including its tunable direct band gap, broad-spectrum light absorption capabilities, and exceptional charge mobility. Nevertheless, pristine BP frequently underperforms, primarily due to issues related to its limited ambient stability and the rapid recombination of photogenerated electron–hole pairs. To overcome these challenges, substantial research efforts have been devoted to the creation of BP-based photocatalysts in recent years. However, there is a noticeable absence of reviews regarding the advancement of BP-based materials for the degradation of ECs in aqueous solutions. Therefore, to fill this gap, a comprehensive review is undertaken. In this review, we first present an in-depth examination of the fabrication processes for bulk BP and BP nanosheets (BPNS). The review conducts a thorough analysis and comparison of the merits and limitations inherent in each method, thereby delineating the most auspicious avenues for future research. Then, in line with the pathways followed by photogenerated electron–hole pairs at the interface, BP-based photocatalysts are systematically categorized into heterojunctions (Type I, Type II, Z-scheme, and S-scheme) and hybrids, and their photocatalytic performances against various ECs and the corresponding degradation mechanisms are comprehensively summarized. Finally, this review presents personal insights into the prospective avenues for advancing the field of BP-based photocatalysts for ECs remediation.

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Antiviral drugs in wastewater are on the rise as emerging contaminants: A comprehensive review of spatiotemporal characteristics, removal technologies and environmental risks

Cited by 19 publications

References 105 publications

In-Silico Assessment of Chemical Disinfectants on Surface Proteins Unveiled Dissimilarity in Antiviral Efficacy and Suitability Towards Pathogenic Viruses

In-Silico Assessment of Chemical Disinfectants on Surface Proteins Unveiled Dissimilarity in Antiviral Efficacy and Suitability Towards Pathogenic Viruses

Solar Light-Driven Degradation of Isoprinosine – Efficiency of the Processes and Kinetic Calculations

Recent Advances in Black Phosphorous-Based Photocatalysts for Degradation of Emerging Contaminants

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