volume 24, issue 3, P809-833 2010
DOI: 10.1016/j.idc.2010.07.001
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Lynne Strasfeld, Sunwen Chou

Abstract: Antiviral drug resistance is an increasing concern in immunocompromised patient populations, where ongoing viral replication and prolonged drug exposure lead to the selection of resistant strains. Rapid diagnosis of resistance can be made by associating characteristic viral mutations with resistance to various drugs as determined by phenotypic assays. Management of drug resistance includes optimization of host factors and drug delivery, selection of alternative therapies based on knowledge of mechanisms of res…

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