Antiviral diterpenes from Salvia officinalis

Tada, Mizuki; Okuno, Kenji; Chiba, Kazuhiro; Ohnishi, Eiko; Yoshii, Takao

doi:10.1016/s0031-9422(00)94798-8

Cited by 111 publications

(75 citation statements)

References 9 publications

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“…Many properties have been reported for this plant, including its antibacterial activity against gram-positive cocci and bacilli such as Staphyloccocu saureus and Bacillus subtilis, and against gram-negative bacilli such as Escherichia coli. The EO also has cytotoxic activity against Vero cells and antiviral activity against HIV, Herpes simplex virus 1 and vesicular stomatitis virus [6][7][8], anti-angiogenic and antitumor effects [9], and antioxidant activity due to osmarinic acid, carnosic acid and phenolic components [10][11][12][13]. Recent studies have identified diterpenoids, triterpenoids, flavonoids and phenolic glycosides isolated from the plant [14][15][16].…”

Section: Introductionmentioning

confidence: 99%

Comparison of Salvia officinalis L. essential oil and antifungal agents against candida species

Badiee¹,

Nasirzadeh²,

Motaffaf³

2012

J Pharm Technol Drug Res

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Background: Systemic fungal infections due to pathogenic yeasts are increasing in high-risk patients, and a need is emerging for novel antifungal agents with potent inhibitory activity toward a wide range of pathogenic fungi. In this study we investigated the composition and antifungal activity of the essential oil of Salvia officinalis (Lamiaceae) against standard species of Candida and compared the results with commercial antifungal agents. Methods: The aerial parts of Saliva officinalis were collected in May 2011. The essential oil was extracted and analyzed by gas chromatography-mass spectrometry. The susceptibility profiles of different Candida species were determined by micro broth dilution assays with oil extracts and a panel of antifungal agents. Results: The minimum inhibitory concentrations of essential oil extracts against C. albicans, C. parapsilosis, C. krusei (standard species), C. albicans and C. glabrata (isolated from patients) were 15.6, 3.9, 31.3, 31.3 and 1.9 µg/ml, respectively. Chemical analysis of the essential oil revealed the presence of 40 components that made up 99.58% of the total composition. Cineole, borneol, α-thujone, ledene, β-pinene, α-humulene and trans-caryophyllene were the major components of the oil. Conclusion:The oil extract of Salvia officinalis showed good antifungal activity, and could serve as a natural alternative to synthetic fungicides for the control of some important fungal diseases.

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Section: Introductionmentioning

confidence: 99%

Comparison of Salvia officinalis L. essential oil and antifungal agents against candida species

Badiee¹,

Nasirzadeh²,

Motaffaf³

2012

J Pharm Technol Drug Res

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“…This plant has been reported to contain various types of secondary metabolites (compounds of essential oil, polyphenols, di-and triterpenoids) with antibacterial, antiviral, anti-inflammatory and antioxidant activities (Baricevic et al, 2001;Cuvelier et al, 1994;Farag et al, 1989;Tada et al, 1994). Recently, antioxidant plant metabolites have attracted a great deal of attention due to their role in the protection against diseases caused by oxidative stress, such as heart disease and cancer (Haraguchi et al, 1995).…”

Section: Introductionmentioning

confidence: 99%

Establishment of Salvia officinalis L. Hairy Root Cultures for the Production of Rosmarinic Acid

Grzegorczyk

Królicka

Wysokińska

2006

Zeitschrift Für Naturforschung C

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Shoots of Salvia officinalis, a medicinally important plant, were infected with Agrobacterium rhizogenes strains ATCC 15834 and A4 which led to the induction of hairy roots in 57% and 37% of the explants, respectively. Seven lines of hairy roots were established in WP liquid medium under light and dark conditions. The transformed nature of the root lines was confirmed by polymerase chain reaction using rolB and rolC specific primers. Transformed root cultures of Salvia officinalis showed variations in biomass and rosmarinic acid production depending on the bacterial strain used for transformation and the root line analyzed. Both parameters (growth and rosmarinic acid content) of ATCC 15834-induced lines were significantly higher than the A4-induced lines. The maximum accumulation of rosmarinic acid (about 45 mg g Ð1 of dry weight) was achieved by hairy root line 1 (HR-1) at the end of the culture period (45Ð50 days). The level was significantly higher than that found in untransformed root culture (19 mg g Ð1 of dry wt).

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“…Among them, diterpenoids are an interesting group of secondary metabolites due to their biological activities. These compounds are widely distributed in nature and it has been described that some have antibacterial 7 , antiviral 8 and antifungal activities 9 . Cotoras et al (2001) reported the effect of the diterpenoid 3β -hydroxykaurenoic acid on the mycelial growth and conidia germination of B. cinerea 10 .…”

Section: Introductionmentioning

confidence: 99%

Characterization of the Antifungal Activity Against Botrytis Cinerea of Sclareol and 13-Epi-Sclareol, Two Labdane-Type Diterpenoids

Mendoza

Sepúlveda

Melo

et al. 2015

J. Chil. Chem. Soc.

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The antifungal activity of Sclareol and 13-epi-Sclareol, two labdane-type diterpenoids, on mycelial growth of the phytopathogenic fungus Botrytis cinerea was evaluated. Diterpenoid fungitoxicity was assessed using the radial growth test method. Both diterpenoids inhibited the mycelial growth of B. cinerea in solid medium; however the inhibitory activity of Sclareol was slightly higher than 13-epi-Sclareol with IC 50 value of 237.6 µg/mL and 268.8 µg/mL, respectively. On the other hand, both labdane-type diterpenoids did not alter the plasmatic membrane integrity; however the oxygen consumption of B. cinerea germinating conidia was affected. The evidence suggests that action mechanism of these molecules would be related to the uncoupling of mitochondrial oxidative phosphorylation. Finally, biotransformation of Sclareol by B. cinerea was analysed and the main biotransformed metabolite was identified as 3β-hydroxysclareol.

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Antiviral diterpenes from Salvia officinalis

Cited by 111 publications

References 9 publications

Comparison of Salvia officinalis L. essential oil and antifungal agents against candida species

Comparison of Salvia officinalis L. essential oil and antifungal agents against candida species

Establishment of Salvia officinalis L. Hairy Root Cultures for the Production of Rosmarinic Acid

Characterization of the Antifungal Activity Against Botrytis Cinerea of Sclareol and 13-Epi-Sclareol, Two Labdane-Type Diterpenoids

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