Antiviral Chromone Alkaloids from the Cigar Tobacco Leaves Derived Endophytic Fungus Aspergillus lentulus

Wu, Yunlong; Zhao, Gaokun; Liu, Ziyi; Tan, Tao; Zai-ming, LI; Zhou, Min; Yao, Heng; Li, Yin-Ke; Wang, Weiguang; Hu, Qiu‐Fen; Kong, Guanghui

doi:10.1007/s10600-023-04096-3

Cited by 2 publications

(3 citation statements)

References 16 publications

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“…Chromone 115 displayed strong inhibitory effects on NO production with an IC 50 value of 4.094 ± 0.8 μM (indomethacin IC 50 = 35.8 ± 0.5 μM). Wu and co-workers also isolated two new chromone alkaloids ( 116 and 117 , Figure ) from fungi Aspergillus lentulus obtained from the leaves of cigar tobacco . The structures of the compounds were established by spectroscopic analysis, and the new chromones were tested for their anti-TMV activities.…”

Section: Chromones and Chromanones From Natural Sourcesmentioning

confidence: 99%

“…Wu and co-workers also isolated two new chromone alkaloids ( 116 and 117 , Figure 15 ) from fungi Aspergillus lentulus obtained from the leaves of cigar tobacco. 76 The structures of the compounds were established by spectroscopic analysis, and the new chromones were tested for their anti-TMV activities. Compound 117 showed higher anti-TMV activity than the positive control, with an inhibition rate of 44.2% (ningnanmycin inhibition rate of 34.8%), while compound 116 also exhibited anti-TMV activities with an inhibition rate of 31.8%.…”

Section: Chromones and Chromanones From Natural Sourcesmentioning

confidence: 99%

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Biological and Medicinal Properties of Natural Chromones and Chromanones

Gaspar,

Garrido,

Borges

et al. 2024

ACS Omega

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Emerging threats to human health require a concerted effort to search for new treatment therapies. One of the biggest challenges is finding medicines with few or no side effects. Natural products have historically contributed to major advances in the field of pharmacotherapy, as they offer special characteristics compared to conventional synthetic molecules. Interest in natural products is being revitalized, in a continuous search for lead structures that can be used as models for the development of new medicines by the pharmaceutical industry. Chromone and chromanones are recognized as privileged structures and useful templates for the design of diversified therapeutic molecules with potential pharmacological interest. Chromones and chromanones are widely distributed in plants and fungi, and significant biological activities, namely antioxidant, anti-inflammatory, antimicrobial, antiviral, etc., have been reported for these compounds, suggesting their potential as lead drug candidates. This review aims to update the literature published over the last 6 years (2018–2023) regarding the natural occurrence and biological activity of chromones and chromanones, highlighting the recent findings and the perspectives that they hold for future research and applications namely in health, cosmetic, and food industries.

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Section: Chromones and Chromanones From Natural Sourcesmentioning

confidence: 99%

Section: Chromones and Chromanones From Natural Sourcesmentioning

confidence: 99%

Biological and Medicinal Properties of Natural Chromones and Chromanones

Gaspar,

Garrido,

Borges

et al. 2024

ACS Omega

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“…The exploration of novel active components and the development of new pesticides through structural modifications of natural products are crucial strategies [8]. Chromone, a botanical active component, and its derivatives are widely distributed in various plant parts such as roots, flowers, pericarps, and stems, exhibiting a broad spectrum of biological properties including antifungal, antibacterial, antiviral, and anticancer properties [9][10][11][12][13][14][15][16]. 4-Chromanone, which belongs to the chromone compound family, exhibits a wide range of significant biological and pharmaceutical activities, including anticancer, antioxidant, antifungal, and antibacterial activities [17].…”

Section: Introductionmentioning

confidence: 99%

Novel 4-Chromanone-Derived Compounds as Plant Immunity Inducers against CMV Disease in Passiflora spp. (Passion Fruit)

Wu,

Yu,

Xiao

et al. 2024

Molecules

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This study involved the design and synthesis of a series of novel 4-chromanone-derived compounds. Their in vivo anti-cucumber mosaic virus (CMV) activity in field trials against CMV disease in Passiflora spp. was then assessed. Bioassay results demonstrated that compounds 7c and 7g exhibited remarkable curative effects and protection against CMV, with inhibition rates of 57.69% and 51.73% and 56.13% and 52.39%, respectively, surpassing those of dufulin and comparable to ningnanmycin. Field trials results indicated that compound 7c displayed significant efficacy against CMV disease in Passiflora spp. (passion fruit) after the third spraying at a concentration of 200 mg/L, with a relative control efficiency of 47.49%, surpassing that of dufulin and comparable to ningnanmycin. Meanwhile, nutritional quality test results revealed that compound 7c effectively enhanced the disease resistance of Passiflora spp., as evidenced by significant increases in soluble protein, soluble sugar, total phenol, and chlorophyll contents in Passiflora spp. leaves as well as improved the flavor and taste of Passiflora spp. fruits, as demonstrated by notable increases in soluble protein, soluble sugar, soluble solid, and vitamin C contents in Passiflora spp. fruits. Additionally, a transcriptome analysis revealed that compound 7c primarily targeted the abscisic acid (ABA) signaling pathway, a crucial plant hormone signal transduction pathway, thereby augmenting resistance against CMV disease in Passiflora spp. Therefore, this study demonstrates the potential application of these novel 4-chromanone-derived compounds as effective inducers of plant immunity for controlling CMV disease in Passiflora spp. in the coming decades.

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Antiviral Chromone Alkaloids from the Cigar Tobacco Leaves Derived Endophytic Fungus Aspergillus lentulus

Cited by 2 publications

References 16 publications

Biological and Medicinal Properties of Natural Chromones and Chromanones

Biological and Medicinal Properties of Natural Chromones and Chromanones

Novel 4-Chromanone-Derived Compounds as Plant Immunity Inducers against CMV Disease in Passiflora spp. (Passion Fruit)

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