2012
DOI: 10.1128/aac.05555-11
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Antiviral Breadth and Combination Potential of Peptide Triazole HIV-1 Entry Inhibitors

Abstract: The first stage of human immunodeficiency virus type 1 (HIV-1) infection involves the fusion of viral and host cellular membranes mediated by viral envelope glycoprotein gp120. Inhibitors that specifically target gp120 are gaining increased attention as therapeutics or preventatives to prevent the spread of HIV-1. One promising new group of inhibitors is the peptide triazoles, which bind to gp120 and simultaneously block its interaction with both CD4 and the coreceptor. In this study, we assessed the most pote… Show more

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Cited by 34 publications
(59 citation statements)
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“…10 Strikingly, in addition to being potent cell infection inhibitors, this class of compounds induces shedding of gp120, thus inactivating the virus before cell encounter. 11 In addition, peptide triazole thiols (PTTs), PTs containing a free sulfhydryl group (SH) on Cys at the C-terminus, cause envelope disruption and p24 capsid protein release from the virus lumen.…”
Section: Introductionmentioning
confidence: 99%
“…10 Strikingly, in addition to being potent cell infection inhibitors, this class of compounds induces shedding of gp120, thus inactivating the virus before cell encounter. 11 In addition, peptide triazole thiols (PTTs), PTs containing a free sulfhydryl group (SH) on Cys at the C-terminus, cause envelope disruption and p24 capsid protein release from the virus lumen.…”
Section: Introductionmentioning
confidence: 99%
“…We also evaluated the effect of cyanovirin-N, a lectin that binds high-mannose glycans in the gp120 outer domain, which has been observed before to not compete with peptide triazole binding. 20 In contrast to 2G12, cyanovirin-N did not inhibit p24 release induced by the PTTs 1 , 2 , or 8 (Figure 5B). Based on the docking model of Figure 6, another possible site of disulfide interaction is located in the V1/V2 loop encompassing the disulfide C119–C205.…”
Section: Resultsmentioning
confidence: 83%
“…The broadly neutralizing gp120 antibody 2G12 has previously been shown to bind to the mannose-rich epitope at the base of the gp120 V3 loop 19 but to not affect PT binding 20 (Figure 5D). Inhibition assays with 2G12 were performed with 1 (positive control), 2 (the longest of the truncated virolytic peptides), and 8 (the shortest peptide truncate that still causes observable p24 release).…”
Section: Resultsmentioning
confidence: 93%
“…The structures, gp120 binding potencies, and antiviral activities of the peptide triazoles HNG-156, KR13, and UM15 utilized in this study have been described previously. 5,19,26 All of these compounds (added to the viral suspensions 30 min before infection) were found to exert a dose-dependent inhibitory effect on the HIV infection of B-THP-1/DC-SIGN cells. At (Fig.…”
mentioning
confidence: 99%
“…Peptide triazoles are also not toxic to cells at the studied concentrations. 19,26 There is an urgent need to develop new effective and affordable strategies against HIV, taking into account the chronic character of this disease (in case of permanent treatment) that necessitates the use of drugs with the lowest side effects possible. 30 To the best of our knowledge, this is the first study to apply dextran/oligodextran as a base for the development of biocompatible DC-SIGN and MR (CD206) ligands in the setting of infections including HIV and tuberculosis.…”
mentioning
confidence: 99%