Antiviral and Virucidal Activities of Umesu Phenolics on Influenza Viruses

Ikeda, Keiko; Nishide, Mitsunori; Tsujimoto, Kazuko; Nagashima, Sayuri; Kuwahara, Tomomi; Mitani, Takahiko; Koyama, A. Hajime

doi:10.7883/yoken.jjid.2018.522

Cited by 10 publications

(5 citation statements)

References 17 publications

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“…Plant phenolics are associated with a significant antiviral capacity [20][21][22][23][24][25]. Indeed, numerous phenolic compounds exert potent antiviral capacity against the coronavirus family including novel SARS-CoV-2 virus [18,[26][27][28][29].…”

Section: Antiviral Effectsmentioning

confidence: 99%

Targeting phytoprotection in the COVID-19-induced lung damage and associated systemic effects—the evidence-based 3PM proposition to mitigate individual risks

et al. 2021

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The risks related to the COVID-19 are multi-faceted including but by far not restricted to the following: direct health risks by poorly understood effects of COVID-19 infection, overloaded capacities of healthcare units, restricted and slowed down care of patients with non-communicable disorders such as cancer, neurologic and cardiovascular pathologies, among others; social risks—restricted and broken social contacts, isolation, professional disruption, explosion of aggression in the society, violence in the familial environment; mental risks—loneliness, helplessness, defenceless, depressions; and economic risks—slowed down industrial productivity, broken delivery chains, unemployment, bankrupted SMEs, inflation, decreased capacity of the state to perform socially important programs and to support socio-economically weak subgroups in the population. Directly or indirectly, the above listed risks will get reflected in a healthcare occupation and workload which is a tremendous long-term challenge for the healthcare capacity and robustness. The article does not pretend to provide solutions for all kind of health risks. However, it aims to present the scientific evidence of great clinical utility for primary, secondary, and tertiary care to protect affected individuals in a cost-effective manner. To this end, due to pronounced antimicrobial, antioxidant, anti-inflammatory, and antiviral properties, naturally occurring plant substances are capable to protect affected individuals against COVID-19-associated life-threatening complications such as lung damage. Furthermore, they can be highly effective, if being applied to secondary and tertiary care of noncommunicable diseases under pandemic condition. Thus, the stratification of patients evaluating specific health conditions such as sleep quality, periodontitis, smoking, chronic inflammation and diseases, metabolic disorders and obesity, vascular dysfunction, and cancers would enable effective managemenet of COVID-19-associated complications in primary, secondary, and tertiary care in the context of predictive, preventive, and personalized medicine (3PM).

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Section: Antiviral Effectsmentioning

confidence: 99%

Targeting phytoprotection in the COVID-19-induced lung damage and associated systemic effects—the evidence-based 3PM proposition to mitigate individual risks

et al. 2021

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“…Numerous studies have been published on the antiviral properties of several phenolic compounds. (Herrmann and Kucera, 1967;Serkedzhieva et al, 1986a,b;Serkedzhieva and Manolova, 1988;Abou-Karam and Shier, 1992;Nagai et al, 1995;Semple et al, 1999;Gonçalves et al, 2001;Likhitwitayawuid et al, 2005;Sokmen et al, 2005;Cai et al, 2006;Dhiman, 2011;Xiong et al, 2012;Pang et al, 2014;Malik et al, 2016;Ma et al, 2018;Min et al, 2018;Seong et al, 2018;Nishide et al, 2019;Ikeda et al, 2020;Ulomskiy et al, 2020;Yin et al, 2014). Moreover, the antiviral activity of several flavonoids, the most abundant subclass of phenolics, has been experimentally confirmed against coronavirus infection (Russo et al, 2020).…”

Section: Introductionmentioning

confidence: 97%

COVID-19: docking-based virtual screening and molecular dynamics study to identify potential SARS-CoV-2 spike protein inhibitors from plant-based phenolic compounds

Moradkhani¹,

Farmani²,

Saidijam³

et al. 2021

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A novel coronavirus, known as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), enters into the host cells through an interaction between its surface spike protein (S-protein) and the angiotensin-converting enzyme 2 receptors, leading to coronavirus disease 2019 . Using effective S-protein inhibitors may reduce the virulence of the virus. Molecular docking was performed to evaluate the binding affinity of 97 phenolic compounds (phenolics) with the SARS-CoV-2 S-protein receptor-binding domain (RBD). Molecular dynamics (MD) simulation was carried out to assess the stability of interactions between top-ranked compounds and S-protein RBD. Pharmacokinetics and toxicity of top-ranked inhibitors were also studied. Furthermore, the essential residues involved in ligand binding, based on the degree of each amino acid in the ligand-amino acid interaction (LAI) network for S-protein, were identified. Molecular docking and MD simulations were performed utilizing the AutoDock and Discovery Studio Client version, respectively. The LAI network was analyzed using the Cytoscape software. Pharmacokinetics and toxicity of top-ranked compounds were studied using bioinformatics webservers. It was estimated that nine of the studied phenolics can bind to the SARS-CoV-2 S-protein at the nanomolar scale with a considerable estimated energy of binding (∆G binding < -10 kcal/mol). Eight of them revealed stable docked pose after MD simulation. The results of the present study may be useful in the prevention and therapeutic perspectives of COVID-19. However, further in vitro and in vivo validation tests are required in the future.

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“…[3][4][5][6] In recent years, Prunus mume fruit extracts have been reported with various beneficial effects, such as the improvement of blood circulation 7 and energy metabolism. 8 It has also been shown to possess a wide variety of other beneficial effects, including anticancer, [9][10][11][12] anti-microbial, 13 anti-inflammatory, 14,15 antioxidant, 16,17 anti-fatigue, 18 antiviral, 19,20 and other bioactivities properties. [21][22][23][24][25][26][27] According to the World Health Organization (WHO), cancer has become the second leading cause of death after cardiovascular and cerebrovascular diseases.…”

Section: Introductionmentioning

confidence: 99%

“…3–6 In recent years, Prunus mume fruit extracts have been reported with various beneficial effects, such as the improvement of blood circulation 7 and energy metabolism. 8 It has also been shown to possess a wide variety of other beneficial effects, including anticancer, 9–12 anti-microbial, 13 anti-inflammatory, 14,15 antioxidant, 16,17 anti-fatigue, 18 antiviral, 19,20 and other bioactivities properties. 21–27…”

Section: Introductionmentioning

confidence: 99%