Antiviral and cytotoxic activities of some Indonesian plants

Dévéhat, Françoise Lohézic-Le; Bakhtiar, Amri; Bézivin, Carine; Amoros, M.; Boustié, Joël

doi:10.1016/s0367-326x(02)00125-9

Cited by 68 publications

(44 citation statements)

References 24 publications

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“…Lohézic-Le Dévéhat et al (17) reported the presence of flavonoid constituents in L. ferrugineus. However, in the present study, the FTIR of LFME and its active NBF-LFME fraction showed no fingerprint region as well as the absence of a carbonyl region, which could mean that the flavonoid content of the extract and its fractions may not be present in sufficient quantity to detect or may not contribute to the activity of the extract.…”

Section: Discussionmentioning

confidence: 99%

Cardiovascular activity of the n-butanol fraction of the methanol extract of Loranthus ferrugineus Roxb.

Ameer

Salman

Siddiqui

et al. 2010

Braz J Med Biol Res

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Section: Discussionmentioning

confidence: 99%

Cardiovascular activity of the n-butanol fraction of the methanol extract of Loranthus ferrugineus Roxb.

Ameer

Salman

Siddiqui

et al. 2010

Braz J Med Biol Res

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“…Its phytochemistry has been object of extensive reviews. 10,11) With regard to the ethnopharmacological information, while the pungent and aromatic fruits of some species of Piper are used as spices, most of them find wide application in traditional systems of medicine 10,11) as insecticides, 7,[12][13][14] antivirals, 15,16) antimicrobials [17][18][19][20][21] and particularly antifungals. [22][23][24][25][26][27][28] These biological properties have been attributed to the presence of lignans and/or amides, such as alkyl or olefinic isobutylamides, 7,23,29) flavonoids, kawa-lactones, butenolides and cyclohexane epoxides, among others.…”

Section: )mentioning

confidence: 99%

Evaluation of Antifungal Activity of Piper solmsianum C. DC. var. solmsianum (Piperaceae)

Campos

Filho

Silva

et al. 2005

Biological & Pharmaceutical Bulletin

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The incidence of opportunistic fungal infections in immunocompromised patients, such as those undergoing treatment with immunosuppressive drugs, intensive chemotherapy, AIDS patients and neonates, is increasing at an alarming rate. 1,2) These mycoses are very difficult to eradicate, and present an enormous challenge for healthcare providers. 3,4) The diversity of plant species in Brazil, together with their known ethnopharmacological uses, creates enormous potential for finding new structures with antifungal properties. 5,6) The Piperaceae is a vast family of plants, which has been extensively used for medicinal purposes.7) It comprises about 10 genus and approximately 2000 species, most of them herbaceous, 8) which are found mainly in tropical areas. Piper and Peperomia, the two greatest genera of the family, are well-represented in the Brazilian flora. 9)Within the Piperaceae family, the genus Piper has over 700 species, distributed throughout the tropical and subtropical regions of the world. Its phytochemistry has been object of extensive reviews. 10,11) With regard to the ethnopharmacological information, while the pungent and aromatic fruits of some species of Piper are used as spices, most of them find wide application in traditional systems of medicine 10,11) as insecticides, 7,[12][13][14] antivirals, 15,16) antimicrobials [17][18][19][20][21] and particularly antifungals. [22][23][24][25][26][27][28] These biological properties have been attributed to the presence of lignans and/or amides, such as alkyl or olefinic isobutylamides, 7,23,29) flavonoids, kawa-lactones, butenolides and cyclohexane epoxides, among others. 10)Among the different species of Piper growing in Brazil, Piper solmsianum (syn. P. leucathum or P. santosanum) known popularly as "pariparoba", is a shrub that measures 1-3 m. There are few reports on the chemical or biological studies of this plant. In contrast, phytochemical studies indicated the presence of aliphatic hydrocarbons, monoterpenes, sesquiterpenes, arylpropanoids and neolignans. [30][31][32] Recently, we have demonstrated that the fractions and some pure compounds (lignans) from the leaves of this plant exhibit significant activity against Gram-positive bacteria. 33)The current study extends our previous work on the biological properties of P. solmsianum and describes the in vitro antifungal activity of extracts, fractions and pure compounds against a panel of opportunistic pathogenic fungi using the agar dilution method. MATERIALS AND METHODS Plant MaterialPiper solmsianum C. DC. var. solmsianum (Piperaceae) was collected in May, 2001, in Ponta Grossa, State of Paraná, Brazil, and identified by Dr. Elsie Franklin Guimarães (Rio de Janeiro Botanic Museum Herbarium). A voucher specimen was deposited in the same herbarium under the number RB 368597.Phytochemical Analyses Air-dried leaves (1.36 kg) of P. solmsianum var. solmsianum were cut into small pieces and macerated at room temperature for one week in methanol. After filtration, the solvent was removed by rotary evaporat...

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“…Its phytochemistry has been object of extensive reviews (Sengupta & Ray, 1987;Parmar et al, 1997). With regard to the ethnopharmacological information, while the pungent and aromatic fruits of some species of Piper are used as spices, most of them fi nd wide application in traditional systems of medicine (Sengupta & Ray, 1987;Parmar et al, 1997), as insecticides (Chauret et al, 1996;Park et al, 2002;Yang et al, 2002), antivirals (Lohézic-le et al, 2002) antimicrobials (Costantin et al, 2001) and particularly antifungals (Lopez et al, 2001). These biological properties have been attributed to the presence of lignans and/or amides, such as alkyl or olefi nic isobutylamides, fl avonoids, kawalactones, butenolides and cyclohexane epoxides, among others (Parmar et al, 1997).…”

Section: Introductionmentioning

confidence: 99%

Evaluation of larvicidal activity of the methanolic extracts of Piper alatabaccum branches and P. tuberculatum leaves and compounds isolated against Anopheles darlingi

Trindade¹,

Stábeli²,

Facundo³

et al. 2012

Rev. bras. farmacogn.

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Abstract:Piper is a notable genus among Piperaceae due to their secondary metabolites such as lignans, amides, esters and long chain fatty acids used as antiherbivore defenses with comparable effects of pyrethroids, that holds a promise in insect control, including malaria vectors such as Anopheles darlingi, the main vector in the North of Brazil. Methanolic extracts of Piper tuberculatum Jacq., Piperaceae, and P. alatabaccum Trel. & Yunck., Piperaceae, and some isolated compounds, i.e, 3,4,5-trimetoxy-dihydrocinamic acid, dihydropiplartine; piplartine, piplartine-dihydropiplartine and 5,5',7-trimetoxy-3',4'-metilenodioxiflavone were tested as larvicides against A. darlingi. The Lethal Concentrations (LC50 and LC90) of methanolic extracts were 194 and 333 ppm for P. tuberculatum and 235 and 401 ppm for P. alatabacum, respectively. Isolated compounds had lower LC values, e.g. the LC50 and LC90 of the piplartine-dihidropiplartine isolated from both plant species was 40 and 79 ppm, respectively.

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Antiviral and cytotoxic activities of some Indonesian plants

Cited by 68 publications

References 24 publications

Cardiovascular activity of the n-butanol fraction of the methanol extract of Loranthus ferrugineus Roxb.

Cardiovascular activity of the n-butanol fraction of the methanol extract of Loranthus ferrugineus Roxb.

Evaluation of Antifungal Activity of Piper solmsianum C. DC. var. solmsianum (Piperaceae)

Evaluation of larvicidal activity of the methanolic extracts of Piper alatabaccum branches and P. tuberculatum leaves and compounds isolated against Anopheles darlingi

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