Antiviral and Antioxidant Properties of Echinochrome A

Fedoreyev, Sergey A.; Крылова, Н. В.; Mishchenko, Natalia P.; Васильева, Е. А.; Pislyagin, Еvgeny А.; Иунихина, О. В.; Лавров, В. Ф.; Свитич, О. А.; Эбралидзе, Л К; Леонова, Галина Николаевна

doi:10.3390/md16120509

Cited by 68 publications

(47 citation statements)

References 30 publications

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“…Thus, thousands of compounds from various marine organisms such as algae, bacteria, fungi, marine invertebrates or sponges have been screened and 21 of them have demonstrated antiviral activities [17]. In 2018, Fedoreyev et al [2] reported that an antioxidant "soup", containing echinochrome A (pigment of sea urchins), ascorbic acid (vitamin C) and α-Tocopherol (vitamin E) possess in vitro antiviral activity against RNA-containing tick-borne encephalitis virus and DNA-containing herpes simplex virus type 1 [2]. This study also demonstrated that a synergistic effect of antioxidant molecules can be effective against virus infections.…”

Section: Marine Antioxidants and Antiviral Activitymentioning

confidence: 99%

“…Oxidative stress-a loss in the balance between the production of free radicals including reactive oxygen species (ROS) and antioxidant cell signaling pathways [2]-can be a key factor of the pathogenesis in many acute or chronical human diseases [3]. Dietary intake of exogenous antioxidants in humans has a well-known role in preventing and protecting cellular oxidative stress.…”

Section: Introductionmentioning

confidence: 99%

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Marine Algal Antioxidants as Potential Vectors for Controlling Viral Diseases

et al. 2020

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As the COVID-19 epidemic expands in the world, and with the previous SARS epidemic, avian flu, Ebola and AIDS serving as a warning, biomedical and biotechnological research has the task to find solutions to counteract viral entry and pathogenesis. A novel approach can come from marine chemodiversity, recognized as a relevant source for developing a future natural "antiviral pharmacy". Activities of antioxidants against viruses can be exploited to cope with human viral infection, from single individual infections to protection of populations. There is a potentially rich and fruitful reservoir of such compounds thanks to the plethora of bioactive molecules and families present in marine microorganisms. The aim of this communication is to present the state-of-play of what is known on the antiviral activities recognized in (micro)algae, highlighting the different molecules from various algae and their mechanisms of actions, when known. Given the ability of various algal molecules-mainly sulfated polysaccharides-to inhibit viral infection at Stage I (adsorption and invasion of cells), we envisage a need to further investigate the antiviral ability of algae, and their mechanisms of action. Given the advantages of microalgal production compared to other organisms, the opportunity might become reality in a short period of time.

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Section: Marine Antioxidants and Antiviral Activitymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Marine Algal Antioxidants as Potential Vectors for Controlling Viral Diseases

et al. 2020

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“…9 It was established that the sea urchin pigment echinochrome (1) and its mixtures with other antioxidants directly affect the HSV-1 virus particles and improve the antioxidant defense mechanisms in the infected cells. 10 These results demonstrate that echinochrome 1 and related natural hydroxy 1,4-naphthoquinones 2 to 5 (Figure 1) are the promising starting compounds for the development of new antiviral drugs.…”

mentioning

confidence: 81%

“…By contrast, Acyclovir demonstrated only minor virucidal effect (IC 50 >200) against HSV-1, as noted by other researchers. 10,26,27 We can assume that the mechanisms of action of thioglucoside 17 are the direct inactivation of virus particles and partially the inhibition of virus attachment and virus binding. It is well known that natural polyphenols are targeted to the HSV-1 glycoproteins, The results are given as mean ± standard deviation (n = 3).…”

Section: Cytotoxicity and Antiviral Activity Of Compoundsmentioning

confidence: 99%

Synthesis and Screening of Anti-HSV-1 Activity of Thioglucoside Derivatives of Natural Polyhydroxy-1,4-Naphthoquinones

Полоник

Крылова²,

Компанец³

et al. 2019

Natural Product Communications

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Four 1,4-naphthoquinone dithioglucoside derivatives based on natural polyhydroxy-1,4-naphthoquinones were synthesized. These thioglucosides were screened for their antiradical and antiviral activity in vitro. Antiradical activity of tested compounds was determined by the 2,2-diphenyl-1-picrylhydrazyl radical scavenging assay. The anti-herpes simplex virus type 1 (anti-HSV-1) activity of thioglucosides was analyzed by the cytopathic effect inhibition assay and mode of antiviral action was determined by the addition of the tested compounds to uninfected cells, to the virus prior to infection, or to herpes-infected cells. Most effective inhibition of HSV-1 replication was observed at pretreatment of virus by the compounds (direct virucidal effect). The dithioglucoside conjugate with the single β-OH group and lipophilic ethyl substituent in naphthoquinone core showed the greatest antiviral activity.

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“…Somov Institute of Epidemiology and Microbiology (Vladivostok), and Institute of Vaccines and Sera (Moscow) has found that Ech A not only exhibits anti-oxidant properties, but also shows anti-viral activities against tick-borne encephalitis virus and herpes simplex virus type 1. A mixture of Ech A, ascorbic acid and tocopherol (5:5:1) showed even higher anti-oxidant and anti-viral effects in comparison with Ech A itself [13].…”

Section: Ofmentioning

confidence: 93%