Antiviral Activity of Synthetic Peptides Derived from Physiological Proteins

Sala, Arianna; Ardizzoni, Andrea; Ciociola, Tecla; Magliani, Walter; Conti, Stefania; Blasi, Elisabetta; Cermelli, Claudio

doi:10.1159/000494354

Cited by 24 publications

(14 citation statements)

References 41 publications

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“…Finally, Sala et al [127] evaluated several synthetic peptides derived from different human serum proteins against four viruses. Among them, the peptide called KP showed remarkable antiviral activity against HSV-1 (reaching 99% of inhibition), in a virucidal manner.…”

Section: Avps Derived From Mammalsmentioning

confidence: 99%

Antiviral peptides as promising therapeutic drugs

Boas

Campos

Berlanda

et al. 2019

Cell. Mol. Life Sci.

242

175

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While scientific advances have led to large-scale production and widespread distribution of vaccines and antiviral drugs, viruses still remain a major cause of human diseases today. The ever-increasing reports of viral resistance and the emergence and re-emergence of viral epidemics pressure the health and scientific community to constantly find novel molecules with antiviral potential. This search involves numerous different approaches, and the use of antimicrobial peptides has presented itself as an interesting alternative. Even though the number of antimicrobial peptides with antiviral activity is still low, they already show immense potential to become pharmaceutically available antiviral drugs. Such peptides can originate from natural sources, such as those isolated from mammals and from animal venoms, or from artificial sources, when bioinformatics tools are used. This review aims to shed some light on antimicrobial peptides with antiviral activities against human viruses and update the data about the already well-known peptides that are still undergoing studies, emphasizing the most promising ones that may become medicines for clinical use.Publisher's Note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

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Section: Avps Derived From Mammalsmentioning

confidence: 99%

Antiviral peptides as promising therapeutic drugs

Boas

Campos

Berlanda

et al. 2019

Cell. Mol. Life Sci.

242

175

View full text Add to dashboard Cite

show abstract

“…In this context, we evaluated the antiviral action of Cm-p5 derivatives against SARS-CoV-2, ZIKV, and HSV-2. All these viruses are enveloped, and could thus be targeted by peptides that act via interaction with the lipid membrane, regardless of the nucleic acid nature of the viral genome [ 38 ].…”

Section: Discussionmentioning

confidence: 99%

Antimicrobial Activity of Cyclic-Monomeric and Dimeric Derivatives of the Snail-Derived Peptide Cm-p5 against Viral and Multidrug-Resistant Bacterial Strains

et al. 2021

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Cm-p5 is a snail-derived antimicrobial peptide, which demonstrated antifungal activity against the pathogenic strains of Candida albicans. Previously we synthetized a cyclic monomer as well as a parallel and an antiparallel dimer of Cm-p5 with improved antifungal activity. Considering the alarming increase of microbial resistance to conventional antibiotics, here we evaluated the antimicrobial activity of these derivatives against multiresistant and problematic bacteria and against important viral agents. The three peptides showed a moderate activity against Pseudomonas aeruginosa, Klebsiella pneumoniae Extended Spectrum β-Lactamase (ESBL), and Streptococcus agalactiae, with MIC values > 100 µg/mL. They exerted a considerable activity with MIC values between 25–50 µg/mL against Acinetobacter baumanii and Enterococcus faecium. In addition, the two dimers showed a moderate activity against Pseudomonas aeruginosa PA14. The three Cm-p5 derivatives inhibited a virulent extracellular strain of Mycobacterium tuberculosis, in a dose-dependent manner. Moreover, they inhibited Herpes Simplex Virus 2 (HSV-2) infection in a concentration-dependent manner, but had no effect on infection by the Zika Virus (ZIKV) or pseudoparticles of Severe Acute Respiratory Syndrome Corona Virus 2 (SARS-CoV-2). At concentrations of >100 µg/mL, the three new Cm-p5 derivatives showed toxicity on different eukaryotic cells tested. Considering a certain cell toxicity but a potential interesting activity against the multiresistant strains of bacteria and HSV-2, our compounds require future structural optimization.

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“…Depending on the nature of AMP, the targets can be one or more bacteria (Gram-positive or G negative), fungi or viruses (Bai et al, 2007;Chang and Yang, 2013;Hein et al, 2015;H. Zhao et al, 2016;Sala et al, 2019). The propensity to bind membrane is a conclusive feature of AMPs, which may or may not be associated with membrane permeabilization (Varkey et al, 2006).…”

Section: Biological Function and Mode Of Actionmentioning

confidence: 99%

Antimicrobial Peptides in Farm animals: An updated review on its diversity, function, mode of action and therapeutic prospects

Kumar¹,

Ali²,

Singh³

et al. 2020

Preprint

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Antimicrobial peptides (AMPs) are the arsenals of the innate host defense system exhibiting the ancient evolutionarily conserved characteristics that is present in practically all forms of life. Recent years have witnessed emergence of antibiotic resistant bacteria compounded with a slow discovery rate for new antibiotics that has necessitated scientific efforts to search for alternatives to antibiotics. Research on the identification of AMPs has generated very encouraging evidences that they curb infectious pathologies and are also useful as novel biologics to function as immunotherapeutic agents. Being innate, they exhibit least toxicity to the host and exert wide spectrum of biological activity including low resistance among microbes, and increased wound healing actions. Notably, in veterinary science, the constant practice of massive doses of antibiotics with inappropriate withdrawal programs led to the high risk of livestock-associated antimicrobial resistance. Therefore, the world faces tremendous pressure for designing and devising strategies to mitigate the use of antibiotics in animals and keep it safe for the posterity. In this review, we illustrate the diversity of farm animals specific AMPs, their biochemical foundations, mode of action and prospective application in clinics. Subsequently, we present the data for their systematic classification by the major and minor groups, antipathogenic action, and allied bioactivities in the host. Finally, we address the limitations to their clinical implementation and envision areas for further advancement.

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Antiviral Activity of Synthetic Peptides Derived from Physiological Proteins

Cited by 24 publications

References 41 publications

Antiviral peptides as promising therapeutic drugs

Antiviral peptides as promising therapeutic drugs

Antimicrobial Activity of Cyclic-Monomeric and Dimeric Derivatives of the Snail-Derived Peptide Cm-p5 against Viral and Multidrug-Resistant Bacterial Strains

Antimicrobial Peptides in Farm animals: An updated review on its diversity, function, mode of action and therapeutic prospects

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