Antiviral activity of natural and semi-synthetic chromone alkaloids

Effects of some Chinese medicinal plant extracts on five different fungi

“…Many compounds are responsible for plant Xavor, and some of the same herbs and spices are used by humans to season the food, and also serve as useful medicinal compounds. Among those antimicrobial compounds, phenolic compounds, terpenoids, and alkaloids are very important components in antimicrobial or antioxidant eVects and epidemiologists have observed that a diet rich in those compounds may result in a positive health eVect (Fernandez, Garcia, & Saenz, 1996;Houghton, Woldemariam, Khan, Burke, & Mahmood, 1994;Hoult & Paya, 1996;Ríos & Recio, 2005;Rojas, Hernandez, PeredaMiranda, & Mata, 1992;Scalbert, 1991). However, analyses of the active compounds which inhibit the growth of tested fungi were under the way in our laboratory.…”

Synthesis and biological activity of chromones annelated at the C(7)–C(8) bond with heterocycles (review)

“…Activity against human immunodeficiency virus (HIV) and herpes virus was found in alkaloids from the Schumanniophyton plants. The presence of the piperidine ring and unsubstituted hydroxyl groups in their molecules is responsible for the activity against HIV [72]. Comparison of the antiviral activity of all the alkaloids indicated in Section 2.3 [73] showed that schumanniphycin 122 is the most active [72].…”

Discovery of new chromone containing sulfonamides as potent inhibitors of bovine cytosolic carbonic anhydrase

“…They are widely distributed in plant kingdom and form the basic nucleus of important compounds such as anthocyanin and flavonoids. Chromones are also well known for their antimicrobial, 1,2 antitumor, 3,4 and antiviral 5,6 activities. 3-Formylchromones are important synthons in synthetic chemistry for incorporating chromone moieties into other heterocyclic systems or for creating new heterocyclic systems based on chromone ring.…”