Antiviral activity of multifunctional composite based on TiO2-modified hydroxyapatite

Monmaturapoj, Naruporn; Srion, Autcharaporn; Klinsukhon, Wattana; Boonnak, Kobporn; Prahsarn, Chureerat

doi:10.1016/j.msec.2018.06.045

Cited by 43 publications

(32 citation statements)

References 47 publications

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“…This feature of TNPs could provide a microbial control in addition to conventional disinfecting products. TNP’s anti-viral effect has been shown against influenza virus, Newcastle virus, hepatitis B virus, and herpesviruses [ 34 , 35 , 36 , 37 ]. TiO 2 was proposed to have an antiviral effect, targeting both DNA and RNA viruses, airborne and bloodborne pathogens.…”

Section: Discussionmentioning

confidence: 99%

Inactivation of Human Coronavirus by Titania Nanoparticle Coatings and UVC Radiation: Throwing Light on SARS-CoV-2

Khaiboullina

Uppal

Dhabarde

et al. 2020

Viruses

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The newly identified pathogenic human coronavirus, SARS-CoV-2, led to an atypical pneumonia-like severe acute respiratory syndrome (SARS) outbreak called coronavirus disease 2019 (abbreviated as COVID-19). Currently, nearly 77 million cases have been confirmed worldwide with the highest numbers of COVID-19 cases in the United States. Individuals are getting vaccinated with recently approved vaccines, which are highly protective in suppressing COVID-19 symptoms but there will be a long way before the majority of individuals get vaccinated. In the meantime, safety precautions and effective disease control strategies appear to be vital for preventing the virus spread in public places. Due to the longevity of the virus on smooth surfaces, photocatalytic properties of “self-disinfecting/cleaning” surfaces appear to be a promising tool to help guide disinfection policies for controlling SARS-CoV-2 spread in high-traffic areas such as hospitals, grocery stores, airports, schools, and stadiums. Here, we explored the photocatalytic properties of nanosized TiO2 (TNPs) as induced by the UV radiation, towards virus deactivation. Our preliminary results using a close genetic relative of SAR-CoV-2, HCoV-NL63, showed the virucidal efficacy of photoactive TNPs deposited on glass coverslips, as examined by quantitative RT-qPCR and virus infectivity assays. Efforts to extrapolate the underlying concepts described in this study to SARS-CoV-2 are currently underway.

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Section: Discussionmentioning

confidence: 99%

Inactivation of Human Coronavirus by Titania Nanoparticle Coatings and UVC Radiation: Throwing Light on SARS-CoV-2

Khaiboullina

Uppal

Dhabarde

et al. 2020

Viruses

View full text Add to dashboard Cite

show abstract

“…This feature of TNPs could provide a microbial control in addition to conventional disinfecting products. TNP's anti-viral effect has been shown against influenza virus, Newcastle virus, hepatitis B virus and herpesviruses [30][31][32][33] both cause acute respiratory diseases and have similar virion structure (HCoV) [18,35], we speculate that these inactivation parameters will be same for the both viruses.…”

Section: Discussionmentioning

confidence: 98%

In Vitro Inactivation of Human Coronavirus by Titania Nanoparticle Coatings and UVC Radiation: Throwing Light on SARS-CoV-2

Khaiboullina

Uppal

Dhabarde

et al. 2020

Preprint

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The newly identified pathogenic human coronavirus, SARS-CoV-2, led to an atypical pneumonia-like severe acute respiratory syndrome (SARS) outbreak called coronavirus disease 2019 (COVID-19). Currently, nearly 23 million cases have been confirmed worldwide with the highest COVID-19 cases been confirmed in the United States. As there is no vaccine or any effective interventions, massive efforts to create a potential vaccine to combat COVID-19 is underway. In the meantime, safety precautions and effective disease control strategies appear to be vital for preventing the virus spread in the public places. Due to the longevity of the virus on smooth surfaces, photocatalytic properties of self-disinfecting/cleaning surfaces appear to be a promising tool to help guide disinfection policies to control infectious SAR-CoV-2 spread in high-traffic areas such as hospitals, grocery stores, airports, schools, and stadiums. Here, we explored the photocatalytic properties of nanosized TiO2 (TNPs) as induced by the UV radiation, towards virus deactivation. Our preliminary results using close genetic relative of SAR-CoV-2, HCoV-NL63, showed the virucidal efficacy of photoactive TNPs deposited on glass coverslips, as examined by quantitative RT-PCR and virus culture assays. Efforts to extrapolate the underlying concepts described in this study to SARS-CoV-2 are currently underway.

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“…Almost all methods of photocatalytic inhibition only reach a 2 or 4-Log inactivation. The rod-like shape virus was decomposed, and the outer membrane of the viruses have been glued together [203]. The resistance is associated with the viral J o u r n a l P r e -p r o o f characteristic, because as is well-known, a pathogenic characteristic of the virus is the induction of oxidative stress that breaks the intracellular redox balance.…”

Section: Virusmentioning

confidence: 99%

An approach to the photocatalytic mechanism in the TiO2-nanomaterials microorganism interface for the control of infectious processes

Rodríguez-González

Obregón

Patrón-Soberano

et al. 2020

Applied Catalysis B: Environmental

141

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J o u r n a l P r e -p r o o f 2 Graphical Abstract Highlights  Photoactive TiO2 nanomaterials can solve the actual microbial infectious defies  The microbial cell/TiO2 surface approach is key to get the photo-kill mechanism  Microbial preparation requires a reproducible protocol for proper characterization  Advanced surface characterization techniques can unravel the photo-kill mechanism  Generation of ROS, physical injuries and biocidal features confirm the annihilation J o u r n a l P r e -p r o o f Abstract The approach of this timely review considers the current literature that is focused on the interface nanostructure/cell-wall microorganism to understand the annihilation mechanism. Morphological studies use optical and electronic microscopes to determine the physical damage on the cell-wall and the possible cell lysis that confirms the viability and microorganism death. The key parameters of the tailoring the surface of the photoactive nanostructures such as the metal functionalization with bacteriostatic properties, hydrophilicity, textural porosity, morphology and the formation of heterojunction systems, can achieve the effective eradication of the microorganisms under natural conditions, ranging from practical to applications in environment, agriculture, and so on. However, to our knowledge, a comprehensive review of the microorganism/nanomaterial interface approach has rarely been conducted. The final remarks point the ideal photocatalytic way for the effective prevention/eradication of microorganisms, considering the resistance that the microorganism could develop without the appropriate regulatory aspects for human and ecosystem safety. Introduction and background 1. TiO 2 based materials obtained from TiO 2 and its composites J o u r n a l P r e -p r o o f previous studies have demonstrated that photocatalysis can be considered a promising tool in anticancer therapies, since the photocatalyst can kill cancer cells such as HeLa cells, which cause cervical cancer [7]. The energy absorbed by the photocatalyst comprises the range of ultraviolet and/or visible light, even natural sunlight. When the photocatalyst absorbs light, if the energy of the photons is enough to excite the electrons J o u r n a l P r e -p r o o f 6in the valence band (VB), then they migrate to a higher energy level in the conduction band (CB) of the material, as it is illustrated in Fig. 1. This phenomenon generates the charge carriers known as hole-electron pairs. The photogenerated hole can migrate to the surface of the material and react with water molecules or hydroxyl ions to produce hydroxyl radicals, while the photoexcited electron in the conduction band can react with the adsorbed molecular oxygen to produce superoxide ions [8]. Since the report of Fujishima and Honda about the water splitting process using a TiO2 electrode under UV irradiation, numerous studies have exploited the photoactive properties of this material [9,10]. Several reviews have studied the relationship between the electronic properties of TiO2 with...

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Antiviral activity of multifunctional composite based on TiO2-modified hydroxyapatite

Cited by 43 publications

References 47 publications

Inactivation of Human Coronavirus by Titania Nanoparticle Coatings and UVC Radiation: Throwing Light on SARS-CoV-2

Inactivation of Human Coronavirus by Titania Nanoparticle Coatings and UVC Radiation: Throwing Light on SARS-CoV-2

In Vitro Inactivation of Human Coronavirus by Titania Nanoparticle Coatings and UVC Radiation: Throwing Light on SARS-CoV-2

An approach to the photocatalytic mechanism in the TiO2-nanomaterials microorganism interface for the control of infectious processes

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