Antiviral Activity of Macrocyclic Trichothecene Mycotoxins and Related Compounds Baccharinoids B-4 and B-5 against Herpes Simplex Virus Type 2

Okazaki, Katsuichiro; Yoshizawa, Takumi; Kimura, Susumu

doi:10.1080/00021369.1989.10869473

Cited by 1 publication

(2 citation statements)

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“…Macrocyclic trichothecenes such as satratoxin G and roridin A have been previously reported active only against the multiplication of Herpes simplex virus type 2, with IC 50 values in the range 1 ± 2 ng/ml [6]. Our results have shown an inhibitory effect of roridins and verrucarins against JUNV, with a comparable level of efficacy according to the IC 50 values, suggesting that the tricho- Each point is the mean value of duplicate determinations standard deviation.…”

Section: Resultssupporting

confidence: 67%

“…Although these trichothecenes have been associated to various biological properties, such as antibiotic, antimalarial and antileukemic activities and immunotoxic effects [1], [2], [3], [4], very few studies on their antiviral activity have been reported. Both simple (nivalenol, deoxynivalenol, fusarenon, T-2 toxin and related compounds) and macrocyclic (satratoxin G, roridin A and baccharinoids B-4 and B-5) trichothecenes were found to inhibit the replication of Herpes simplex virus [5], [6], [7].…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of the Antiviral Activity Against Junin Virus of Macrocyclic Trichothecenes Produced by the Hypocrealean Epibiont of Baccharis coridifolia

et al. 2002

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Four macrocyclic trichothecenes, roridin A, roridin E, verrucarin A and verrucarin J, produced by the hypocrealean epibiont of Baccharis coridifolia, were evaluated for their inhibitory activity against the arenavirus Junin (JUNV), the etiological agent of Argentine hemorrhagic fever. The trichothecenes achieved a dose-dependent inhibition of JUNV multiplication at concentrations not affecting cell viability. The 50 % inhibitory concentration (IC50) values determined by a virus yield inhibition assay were in the range 1.2 - 4.9 ng/ml. The most active compound was verrucarin J which reduced JUNV yield more than 2 log units and had a similar effect against the arenavirus Tacaribe. The trichothecenes lacked virucidal effects on JUNV virions. From time of addition and removal experiments, it can be concluded that verrucarin J inhibited a late stage in the replicative cycle of JUNV, after 5 h of adsorption.

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Section: Resultssupporting

confidence: 67%